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Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a

Context: The questions of how many individuals and how much time to use for a single testing task are critical in software verification and validation. In software review and usability evaluation contexts, positive effects of using multiple individuals for a task have been found, but software testing has not been studied from this viewpoint. Objective: We study how adding individuals and imposing

Using conceptual dimensions identified by the literature on political leadership, this article compares its transformations at the local level in Europe. Often associated with the alleged shift to governance, the strengthening of the executive comes forward as the underlying tendency in contemporary local leadership. Empowered individualised leadership emerges, in terms of coming to and taking off

We present results of a search for two hypothetical strange dibaryon states, i.e. the H-dibaryon and the possible (Lambda n) over bar bound state. The search is performed with the ALICE detector in central (0-10%) Pb-Pb collisions at root S-NN = 2.76 TeV, by invariant mass analysis in the decay modes (Lambda n) over bar (d) over bar pi(+) and H-dibaryon -> Lambda p pi(-). No evidence for these bou

We present an angle-resolved photoemission study of the valence band of Au/(root 3 x root 3-) - R30 degrees-4H-SiC(0 0 0 1). Several different two-dimensional states could be identified, depending on the Au coverage and annealing temperature. In the case of silicide at the surface, two-dimensional Shockley-like state is observed for higher coverages, but a potential interface state is observed at

Background: Health care policies in many countries aim to enable people with dementia to live in their own homes as long as possible. However, at some point during the disease the needs of a significant number of people with dementia cannot be appropriately met at home and institutional care is required. Evidence as to best practice strategies enabling people with dementia to live at home as long

The tubular cells of the adult kidney are normally mitotically quiescent, in stark contrast to the massive regenerative capacity of the injured renal epithelium. In Paper I we characterized a new cell population of progenitor cells using ALDH as a selection marker. These cells are situated in the proximal tubular epithelium and are called proximal tubular progenitor cells (PTPCs). Gene expression

Associations between various malignancies and work in the pulp and paper industry have been reported but mostly in analyses of mortality rather than incidence. We aimed to study cancer incidence by main mill pulping process, department and gender in a Swedish cohort of pulp and paper mill workers. The cohort (18,113 males and 2,292 females, enrolled from 1939 to 1999 with > 1 year of employment) w

Background: Nocturia, a common complaint in aging men and women, is frequently cited as the cause of nocturnal awakenings leading to sleep loss, daytime fatigue, and reduced quality of life (QOL). Objective: Investigate the association of nocturia with QOL and depressive symptoms among men and women. Design, setting, and participants: A population-based epidemiologic survey of urologic symptoms am

Purpose – The purpose of this paper is to assess how technology-based university research drives innovation in Europe and China. Design/methodology/approach – This paper draws on extensive theoretical research and literature reviews, and presents a framework based on theories on networking, knowledge creation and innovation. It then introduces three European cases to illustrate practical appli

Background: About half a billion people with disabilities in developing countries have limited access to assistive technology. The Convention on the Rights of persons with Disabilities requires governments to take measures to ensure provision of such technologies. To guide implementation of these measures there is a need for understanding health outcomes from a human rights perspective. The object

This study examines globalization of monitoring practices by focusing on how American (U.S.) influences on European firms impact the dismissal risk for these firms’ CEOs. Specifically, we argue that the stronger short term orientation of the American corporate governance system increase the dismissal performance sensitivity faced by European CEOs, indirectly and directly. The former materializes v

Very extreme events occur randomly in space and in time. In this paper daily precipitation from more than 200 stations within a 10 000 km(2) region in the very south of Sweden is analysed. While there is a relation between moderate daily precipitation and annual precipitation, the most extreme events are found to be independent of annual precipitation and also of altitude and distance to the sea.

Methane (CH4) fluxes 1997-2010 were studied by combining remotely sensed normalised difference water index (NDWI) with in situ CH4 fluxes from Rylekaerene, a high-Arctic wet tundra ecosystem in the Zackenberg valley, north-eastern Greenland. In situ CH4 fluxes were measured using the closed-chamber technique. Regression models between in situ CH4 fluxes and environmental variables [soil temperatur

The structure of interest consists of a nanometer thin copper coating, resting on a stiffer substrate. The elastic and plastic properties of the coating are investigated for three crystallographic orientations and two coating thicknesses using nanoindentation simulated by molecular dynamics. The force-displacement curve, the atomic rearrangement, the stresses and the lattice disorder are monitored