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Characteristics and survival of adult Swedish PAH and CTEPH patients 2000–2014

Objectives: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients. Design: Incident PAH and CTEPH

The time of data – conditions for digital knowledge production in big science

Increasingly the material research deals with is cast as data. This is an ambiguous concept, which describes the matter of research in all stages of the research process. From having been seen as a stepping-stone on the way to producing the scientific results, increasingly data is itself positioned as the result. At the same time demands for data preservation and open data are often motivated with

Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden

Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor

Single- and double-stranded DNA binding proteins act in concert to conserve a telomeric DNA core sequence

Telomeres are protective cap structures at the ends of the linear eukaryotic chromosomes, which provide stability to the genome by shielding from degradation and chromosome fusions. The cap consists of telomere-specific proteins binding to the respective single- and double-stranded parts of the telomeric sequence. In addition to the nucleation of the chromatin structure the telomere-binding protei

A modelling investigation into lake-breeze development and convection triggering in the Nam Co Lake basin, Tibetan Plateau

This paper uses the cloud resolving Active Tracer High-resolution Atmospheric Model coupled to the interactive surface model Hybrid in order to investigate the diurnal development of a lake-breeze system at the Nam Co Lake on the Tibetan Plateau. Simulations with several background wind speeds are conducted, and the interaction of the lake breeze with topography and background wind in triggering m

Coupling processes and exchange of energy and reactive and non-reactive trace gases at a forest site - Results of the EGER experiment

To investigate the energy, matter and reactive and non-reactive trace gas exchange between the atmosphere and a spruce forest in the German mountain region, two intensive measuring periods were conducted at the FLUXNET site DE-Bay (Waldstein-Weidenbrunnen) in September/October 2007 and June/July 2008. They were part of the project "ExchanGE processes in mountainous Regions" (EGER). Beyond a brief

A comparative study of human aspects in acclimatization of adobe vernacular architecture : A case from Denmark and Egypt

Today’s architecture swarms with concepts of energy and resource efficient buildings. In contrast, vernacular buildings are characterized by low-tech climatic responsive strategies and by their inhabitants’ resource and energy savings practices during construction and operation of their dwellings. That makes vernacular buildings highly relevant to resource efficiency in contemporary building resea

Comparison of AP-XPS and PLIF Measurements during CO Oxidation over Pd Single Crystals

The interaction between the gas-phase molecules and a catalyst surface is crucial for the surface structure and are therefore important to consider when the active phase of a catalyst is studied. In this study we have used two different techniques to study the gas phase during CO oxidation over Pd single crystals. Gas-phase imaging by planar laser-induced fluorescence (PLIF) shows that a spherical

A pure smoothness condition for Radó’s theorem for α-analytic functions

Let (Formula presented.) be a bounded, simply connected ℂ-convex domain. Let α ∈ ℤ+ n and let f be a function on Ω which is separately (Formula presented.) -smooth with respect to zj (by which we mean jointly (Formula presented.) -smooth with respect to Rezj, Imzj). If f is α-analytic on Ω\f−1(0), then f is α-analytic on Ω. The result is well-known for the case αi = 1, 1 ⩽ i ⩽ n, even when f a pri

Kinetic Influence of Siliceous Reactions on Structure Formation of Mesoporous Silica Formed via the Co-Structure Directing Agent Route

We investigate the mechanism responsible for the formation of mesoporous silica formed with the so-called costructure directing agent (CSDA) route. The synthesis relies on the interaction between silica source (tetraethylorthosilicate), cationic surfactant (C18H37N+(CH3)2(CH2)3N+(CH3)3Br2), and CSDA (carboxyethylsilanetriol), which results in a material functionalized with carboxylic groups. Depen