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The spatiotemporal distribution of historical malaria cases in Sweden: a climatic perspective

BackgroundUnderstanding of the impacts of climatic variability on human health remains poor despite a possibly increasing burden of vector-borne diseases under global warming. Numerous socioeconomic variables make such studies challenging during the modern period while studies of climate–disease relationships in historical times are constrained by a lack of long datasets. Previous studies have ide

Spectral characterization of magic angles in twisted bilayer graphene

Twisted bilayer graphene (TBG) has been experimentally observed to exhibit almost flat bands when the twisting occurs at certain magic angles. In this Letter we show that in the approximation of vanishing AA coupling, the magic angles (at which there exist entirely flat bands) are given as the eigenvalues of a non-Hermitian operator, and that all bands start squeezing exponentially fast as the ang

Heart rate and adverse outcomes in patients with prevalent atrial fibrillation

OBJECTIVE: The optimal target heart rate in patients with prevalent atrial fibrillation (AF) is not well defined. The aim of this study was to analyse the associations between heart rate and adverse outcomes in a large contemporary cohort of patients with prevalent AF.METHODS: From two prospective cohort studies, we included stable AF outpatients who were in AF on the baseline ECG. The main outcom

Probing skin barrier recovery on molecular level following acute wounds : An in vivo/ex vivo study on pigs

Proper skin barrier function is paramount for our survival, and, suffering injury, there is an acute need to restore the lost barrier and prevent development of a chronic wound. We hypothesize that rapid wound closure is more important than immediate perfection of the barrier, whereas specific treatment may facilitate perfection. The aim of the current project was therefore to evaluate the quality

A structural study of 0.06LiNbO3-0.94K0.5Na0.5NbO3 from neutron total scattering analysis

The structure of ferroelectric 0.06LiNbO3-0.94K0.5Na0.5NbO3 (KNNL6) was investigated by the neutron total scattering method in the temperature range of 290-773 K. The Rietveld analysis using the powder neutron diffraction data in the range of 290-773 K indicates transition from a two-phase (monoclinic and tetragonal) mixture at room temperature to tetragonal and cubic phases at higher temperatures

Open Data-driven Usability Improvements of Static Code Analysis and its Challenges

Context: Software development is moving towards a place where data about development is gathered in a systematic fashion in order to improve the practice, for example, in tuning of static code analysis. However, this kind of data gathering has so far primarily happened within organizations, which is unfortunate as it tends to favor larger organizations with more resources for maintenance of develo

The fate of planetesimals formed at planetary gap edges

The presence of rings and gaps in protoplanetary disks are often ascribed to planet-disk interactions, where dust and pebbles are trapped at the edges of planetary-induced gas gaps. Recent works have shown that these are likely sites for planetesimal formation via the streaming instability. Given the large amount of planetesimals that potentially form at gap edges, we address the question of their

The migration-sustainability paradox : transformations in mobile worlds

Migration represents a major transformation of the lives of those involved and has been transformative of societies and economies globally. Yet models of sustainability transformations do not effectively incorporate the movement of populations. There is an apparent migration-sustainability paradox: migration plays a role as a driver of unsustainability as part of economic globalisation, yet simult

Reducing search times and entropy in hospital emergency departments with real-time location systems

Although the consequences of hospital ED crowding have been studied extensively, the causes of crowding are still not well understood. Throughput factors in ED crowding models are difficult to study in a controlled fashion in a dynamic environment where healthcare demand changes rapidly, and physical and human resources suddenly become limited. Opportunities for automated, simultaneous, and low-co

HPV73 in cervical cancer and distribution of HPV73 variants in cervical dysplasia

HPV73 is classified as possibly oncogenic and is not recognized by most commercial primary HPV screening platforms. The aim was to determine the prevalence of HPV73 among invasive cervical cancers, formalin-fixed paraffin embedded (FFPE) samples (N = 69), from southern Sweden during 2009 to 2010. Another aim was to determine proportions of HPV73 among Aptima HPV assay negative cervical cancers (N

Plasma proenkephalin A 119-159 and dipeptidyl peptidase 3 on admission after cardiac arrest help predict long-term neurological outcome

BACKGROUND: A large proportion of adult survivors of cardiac arrest have a poor neurological outcome. Guidelines recommend multimodal neuro-prognostication no earlier than 72-96 hours after cardiac arrest. There is great interest in earlier prognostic markers, including very early markers at admission. The novel blood biomarkers proenkephalin A 119-159 (penKid), bioactive adrenomedullin (bio-ADM)

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgi

Dirac states in the noncentrosymmetric superconductor BiPd

Quantum materials having Dirac fermions in conjunction with superconductivity is believed to be the candidate material to realize exotic physics as well as advanced technology. Angle-resolved photoemission spectroscopy (ARPES), a direct probe of the electronic structure, has been extensively used to study these materials. However, experiments often exhibit conflicting results on dimensionality and

Evaluating the Risk of Digitalis Intoxication Associated With Concomitant Use of Dronedarone and Digoxin Using Real-World Data

Purpose: Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Using real-world data, we evaluated the risk of digitalis intoxication in concomitant users of dronedarone and digoxin compared digoxin-alone users. Methods: We used the Clinformatics DataMart, a US claims database, to identify adult patients with atrial fibrillation (AF) or atrial flutter (AFL) who conco

Object Permanence

Object permanence is the capacity to represent objects as persisting in time and space independently of perception.