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Vildagliptin is a potent, selective and reversible inhibitor of dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for rapid inactivation of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). GLP-1 and GIP are important for the maintenance of normal glucose homeostasis as they enhance the sensitivity of insulin (beta-cell) and glucagon (alpha-cell)
Regular column on performing arts in the weekly newspaper Arbetaren (The Worker).
BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
Threshold electron and total ion yield spectra are presented for the near C and O 1s edge photoexcitation of n- and iso-propanol. To our knowledge these are the first such data for iso-propanol, and represent the first direct measurement of the core ionization energies of these molecules by threshold photoelectron spectroscopy. In particular, the C 1s energies for n-propanol are found to be lower
Objective: Assessing lymph-node status in prostate cancer patients with high accuracy is only possible with surgical staging, despite the evolution of modern imaging techniques. The use of surgical staging has to be balanced against the complications of the procedure, the individual patient's risk for harbouring metastasesand the consequences for the treatment of the patient if such metastases are
BACKGROUND: High expression of the RNA-binding protein RBM3 has previously been found to be associated with good prognosis in breast cancer, ovarian cancer, malignant melanoma and colorectal cancer. The aim of this study was to examine the prognostic impact of immunohistochemical RBM3 expression in prostate cancer. FINDINGS: Immunohistochemical RBM3 expression was examined in a tissue microarray
Abstract in Russian В данной работе был использован фантом Алдерсон-РАНДО для экспериментального определения коэффициентов перехода для условий внешнего облучения. Были смоделированы следующие конфигурации облучения: ротационная геометрия облучения с использованием различных точечных источников (99mTc, 131I + 133Ba, 137Cs, 60Co); передне-задняя и задне-передняя геометрия облучения источником 137CsIn the present paper the Alderson RANDO phantom have been used to experimentally determine conversion coefficients. A limited number of exposure situations were investigated for this purpose: rotational-geometry with different radiation point sources (99mTc, 131I+133Ba, 137Cs, 60Co), AP- and PA-geometry with 137Cs and a special pocket-geometry with 137Cs. All experiments were carried out on a larg
Poly Vinyl Chloride (PVC) flooring material contains phthalates and it has been shown that such materials are important sources for phthalates in indoor dust. Phthalates are suspected endocrine disrupting chemicals (EDCs). Consecutive infants between two and six months old and their mothers were invited. A questionnaire about indoor environmental factors and family life style was used. Urinary met
SVENSKA universitetsledningar tenderar numera att prioritera lärosätets intäkter högre än allt annat, inklusive klassiska akademiska ideal som bildning och fri forskning. Därför fruktar vi att ett genomförande av Jan Björklunds planer kommer att leda till samma slags vansinne i Sverige som vi nu ser i Storbritannien.
Popular Abstract in English From the pure technological perspective (leaving the business aside), the design of electronic devices, such as mobile phones, is an extremely complex process often involving a large number of disciplines, from mastering complicated mathematical models to proficiency of physical and electrical properties of specific materials involved in the manufacturing. In order to oThe methodology behind this work has been to use the concept of algorithm-hardware co-design to achieve efficient solutions related to the digital front-end in mobile receivers. It has been shown that, by looking at algorithms and hardware architectures together, more efficient solutions can be found; i.e., efficient with respect to some design measure. In this thesis the main focus have been plac
Manganese (Mn) is an essential nutrient in humans, but excessive exposure to Mn may cause neurotoxicity. Despite homeostatic regulation, Mn concentrations in blood vary considerably among individuals. We evaluated if common single-nucleotide polymorphisms (SNPs) in SLC30A10, which likely encodes a Mn transporter, influence blood Mn concentrations and neurological function. We measured blood Mn con
Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood. Here, we show that up-regulation of the polyamine system promotes cancer cell survival during hypoxic stress. Hypoxia was found to induce polyamine transport and the key enzyme of
