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Chronic obstructive pulmonary disease (COPD) and asthma both involve inflammation and structural changes in the peripheral airways that are not detectable with current standard tools such as spirometry. Accurate and sensitive assessment of lung function is crucial for early diagnosis, monitoring disease progression, and guiding appropriate treatment.The overall aim of this thesis was to investigat

Objectives: To examine the effects of thiopurine exposure during pregnancy on intrahepatic cholestasis of pregnancy (ICP) in systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) pregnancies using nationwide data from Swedish healthcare registers. Methods: This register-based cohort study included all singleton pregnancies with prevalent SLE or IBD in Sweden, 2007-2022. Exposure

Introduction: Patients with severe haemophilia A (HA) with no family history of haemophilia will be diagnosed upon their first bleeding event. Methods: Herein, we studied the effects of lack of family history in HA and the subsequent delay of diagnosis on bleeding pattern and early treatment, as well as on the risk of inhibitor development. For this purpose, data on 1237 severe HA patients with kn

Lignocellulosic materials (e.g., straw and bran) are gaining interest as feedstocks for the manufacture of higher value products, recognizing xylooligosaccharides (XOS) as interesting prebiotic compounds, and putting enzymes converting xylooligosaccharides into focus. In this work, we are investigating a XOS converting enzyme from the probiotic bacterium Levilactobacillus brevis (formerly Lactobac

Thermal unfolding of whey proteins and whey protein-casein mixtures in simulated milk ultrafiltrate was studied by differential scanning calorimetry. The results are reported as transition enthalpy, temperature of peak maximum, and van’t Hoff enthalpy related to the sharpness of transition. The results of earlier investigations were reviewed. It is suggested that a large part of reported whey

Heat-induced gelation of the bovine whey proteins [serum albumin (BSA), β-lactoglobulin (β-Lg) and α-lactalbumin (α-La)] has been studied individually and in mixture at different conditions by a dynamic rheological method. Values in the shear stiffness modulus (/G*/) appeared on heating at low protein concentration for BSA (∼2%) and at intermediate concentration for β-Lg (∼ 5%). α-La did not form

The Naturum "Flinta" explores the architectural potential of a decommissioned limestone quarry in Malmö. Grounded in SDG 1.5, which focuses on resilience and reduced vulnerability in relation to climate-related events, the proposal investigates duality as a spatial concept. Two contrasting structures embody the qualities found in the site’s geology: flint and porous limestone. Through ma

Denna uppsats undersöker huruvida utvecklare av generativ artificiell intelligens (GENAI) system kan, och bör, erkännas som upphovsmän enligt EU:s upphovsrättsregler för de bilder som genereras med deras system. Teknikens framsteg under det senaste årtiondet har omdefinierat de traditionella föreställningarna om kreativitet och upphovsrätt på sätt som den nuvarande lagstiftningen aldrig avsåg. GenThis thesis examines whether the developers of generative artificial intelligence (GENAI) systems can, and should, be recognised as authors under EU copyright framework for the images generated by their systems. Technological advances over the past decade have redefined traditional conceptions of creativity and copyright in ways that current legislation never anticipated. This study addresses a si

This thesis investigates the integration of artificial intelligence (AI ) within the Swedish courts, with a particular focus on its compatibility with the rights to privacy and a fair trial as enshrined in the Charter of Fundamental Right of the European Union (CFR). As we entered the third decade of the 21st century, a technological revolution, led by AI is transforming various sectors, including

This thesis explores the escalating and often underestimated issue of bird-window collisions, specifically within the Swedish context, through the lens of the built environment. Globally, hundreds of millions of birds die annually from colliding with glass surfaces, with estimates reaching nearly a billion birds in North America alone. This significant threat is compounded by modern architectural

This paper reports on lessons learned during the design of the vessels, including the risk assessments; during the actual build/retrofit; and during the vessels’ operation. The focus is on the gained knowledge, to serve as proofs of concept and as a starting point for other methanol vessel conversions.

The accumulation of heavy metals in soils, often resulting from socio-economic development, poses a significant environmental challenge. Metallic elements can be adsorbed by organic matter and minerals in the soil, eventually accumulating in river sediments. This study aims to assess the extent of metal contamination in the sediments of the El Maleh River and its estuary in the Mohammedia region o

Introduction: Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches. Methods: Rats (~ 300 g) were divided into four grou

Background: Skin pain is a common symptom in patients with chronic hand eczema (CHE); however, its association with increased analgesic use has not been thoroughly investigated. Objectives: To examine analgesic use (paracetamol, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids and gabapentin/pregabalin) among patients with CHE compared to a control group. Methods: Data were obtained from the

Pollinators such as Bombus terrestris play a vital role in ecosystem stability and agricultural productivity. Developing methods to estimate key biological traits such as age and weight is crucial for advancing ecological understanding and conservation efforts. In eusocial insects like B. terrestris, age and weight influence behaviour, task allocation, and survivability, but traditional methods fo

Data and code are essential for ensuring the credibility of scientific results and facilitating reproducibility, areas in which journal sharing policies play a crucial role. However, in ecology and evolution, we still do not know how widespread data- and code-sharing policies are, how accessible they are, and whether journals support data and code peer review. Here, we first assessed the clarity,

The implementation of water-related environmental measures (WREMs) in agricultural businesses presents an opportunity to align food production with sustainable value creation through ecosystem services. However, the complexity of adopting these measures, and making them a part of business models, necessitates the involvement of intermediaries to facilitate business opportunities that align with go

Introduction: Device-aided therapies (DATs) have been developed to provide continuous drug delivery (CDD) to people with advanced Parkinson’s disease (PD) whose symptoms can no longer be effectively managed with oral or transdermal therapy. Intrajejunal infusion of levodopa–carbidopa intestinal gel (LCIG), delivered via the CADD Legacy 1400 pump, is an established CDD option, while levodopa–entaca