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Bivalirudin versus heparin monotherapy in myocardial infarction
BACKGROUND: The comparative efficacy of various anticoagulation strategies has not been clearly established in patients with acute myocardial infarction who are undergoing percutaneous coronary intervention (PCI) according to current practice, which includes the use of radial-artery access for PCI and administration of potent P2Y12 inhibitors without the planned use of glycoprotein IIb/IIIa inhibi
Experiences and outcome from the implementation of a national Swedish automated external defibrillator registry
Background: Early cardiopulmonary resuscitation (CPR) and defibrillation with an Automated External Defibrillator (AED) increase survival from out-of-hospital cardiac arrest (OHCA). Although international guidelines recommend the use of AED registries to increase AED use, little is known about implementation. The aim of this paper is to describe the development of a national AED registry, to analy
Biosensing using arrays of vertical semiconductor nanowires : mechanosensing and biomarker detection
Due to their high aspect ratio and increased surface-to-foot-print area, arrays of vertical semiconductor nanowires are used in numerous biological applications, such as cell transfection and biosensing. Here we focus on two specific valuable biosensing approaches that, so far, have received relatively limited attention in terms of their potential capabilities: cellular mechanosensing and lightgui
Association between Year of Birth and 1-Year Survival among Extremely Preterm Infants in Sweden during 2004-2007 and 2014-2016
Importance: Since 2004-2007, national guidelines and recommendations have been developed for the management of extremely preterm births in Sweden. If and how more uniform management has affected infant survival is unknown. Objective: To compare survival of extremely preterm infants born during 2004-2007 with survival of infants born during 2014-2016. Design, Setting and Participants: All births at
Estimating glomerular filtration rate at the transition from pediatric to adult care
The current Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend the use of the bedside creatinine-based Chronic Kidney Disease in Children (CKiD) equation to estimate glomerular filtration rate (GFR) in children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in adults. However, this approach causes implausible changes in estimated GFR (eGFR) at the
The effect of schizophrenia on major adverse cardiac events, length of hospital stay, and prevalence of somatic comorbidities following acute coronary syndrome
AIMS: We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), and comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia.METHODS AND RESULTS: This Danish register study included patients diagnosed with ACS in the period between 1995 and 2013 with a preceding diagnosis o
A review of the potential impacts of climate change on the safety and performance of bridges
An overabundance of evidence, both observational and from model projections, indicate that changes to the climate system are taking place at unprecedented rates. Although the magnitudes of these changes involve large uncertainties, the fact that our climate is changing is unequivocal. To ensure an unimpaired functionality of our societies,it is therefore of crucial importance to study the potentia
Aboveground insect herbivory increases plant competitive asymmetry, while belowground herbivory mitigates the effect
Insect herbivores can shift the composition of a plant community, but the mechanismunderlying such shifts remains largely unexplored. A possibility is that insects alter thecompetitive symmetry between plant species. The effect of herbivory on competitionlikely depends on whether the plants are subjected to aboveground or belowgroundherbivory or both, and also depends on soil nitrogen levels. It i
After de-centering: a new research agenda for state making
If They Can’t Change, Why Support Change? Implicit Theories About Groups, Social Dominance Orientation and Political Identity
In three studies across three cultures (U.S., Sweden, and Israel), we examine whether implicit theories about groups are associated with political identity and whether this relationship is mediated by Social Dominance Orientation (SDO). Study 1 found that raising the salience of entity beliefs leads to increased right-wing political self-identification on social issues, although no such effect was
Experimental and theoretical 2p core-level spectra of size-selected gas-phase aluminum and silicon cluster cations : Chemical shifts, geometric structure, and coordination-dependent screening
We present 2p core-level spectra of size-selected aluminum and silicon cluster cations from soft X-ray photoionization efficiency curves and density functional theory. The experimental and theoretical results are in very good quantitative agreement and allow for geometric structure determination. New ground state geometries for Al 12 + , Si 15 + , Si 16 + , and Si 19 + are proposed on thi
Long-term outcomes of patients with Takayasu arteritis and renal artery involvement : A cohort study
Objective. To describe the long-term outcomes of patients with Takayasu arteritis (TAK) and renal artery involvement (RAI). Methods. A retrospective review of 122 patients with TAK at three tertiary centres in Canada, Sweden and the UK. Data on demographics, laboratory and clinical parameters, medications and angiography findings were collected. Non-renal and renal parameters were compared at bas
The Psychological Science Accelerator: Advancing Psychology Through a Distributed Collaborative Network
Stand-Alone Artificial Intelligence for Breast Cancer Detection in Mammography : Comparison With 101 Radiologists
BACKGROUND: Artificial intelligence (AI) systems performing at radiologist-like levels in the evaluation of digital mammography (DM) would improve breast cancer screening accuracy and efficiency. We aimed to compare the stand-alone performance of an AI system to that of radiologists in detecting breast cancer in DM.METHODS: Nine multi-reader, multi-case study datasets previously used for different
Energy efficiency as a wicked problem
Together with increased shares of renewable energy supply, improved energy efficiency is the foremost means of mitigating climate change. However, the energy efficiency potential is far from being realized, which is commonly explained by the existence of various barriers to energy efficiency. Initially mentioned by Churchman, the term "wicked problems" became established in the 1970s, meaning a ki
The 4.2 ka BP Event in the Mediterranean region : An overview
The Mediterranean region and the Levant have returned some of the clearest evidence of a climatically dry period occurring around 4200 years ago. However, some regional evidence is controversial and contradictory, and issues remain regarding timing, progression, and regional articulation of this event. In this paper, we review the evidence from selected proxies (sea-surface temperature, precipita
