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Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression. CART expression was found in glucose-
Diesel engines are one of the most important power generating units these days. Increasing greenhouse gas emissions level and the need for energy security has prompted increasing research into alternative fuels for diesel engines. Biodiesel is the most popular amongst the alternatives for diesel fuel as it is biodegradable, renewable and can be produced domestically from vegetable oils. In recent
Purpose: Manufacturer specifications for the resolution of an additive manufacturing (AM) machine can be ten times smaller (more optimistic) than the actual size of manufacturable features. Existing methods used to establish a manufacturable design rule-set are conservative piecewise-constant approximations. This paper aims to evaluate the effectiveness of a first-order model for producing improve
The concept of myth is far from foreign to geographical research, yet its definition and use has been both varied and assumed, leaving much of its potential geographically unexplored. Myths – naturalised stories which reflect ideology, alleviate anxiety, and guide everyday practices – instil place with meaning. Following the tradition within human geography of engaging with issues intersecting per
Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR iTreatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic a
Aim: To add to our knowledge concerning the key elements involved in the individual’s experience of growing up with substance abusing parents and the resulting challenges this involved for their own parenthood. Methods: In-depth interviews were conducted with 19 parents who had participated in a mental health intervention programme. All had experienced substance abusing parents in their family of
Collaborative networks provide a viable means for destination management organisations (DMOs) to engage small enterprises in collaborative destination development, and may offer a means to steer destinations toward small enterprises in collaborative destination development, and may offer a means to steer destinations toward sustainability. However, the use of collaborative networks in destination
The book took as its starting point the distinction practised by Roland Barthes between texts of pleasure and texts of jouissance. All the chapters in the book are a commentarius perpetuus at the century-long querelle des anciens et des modernes, the purpose being the aesthetic criteria in establishing the chronotope of masterpiece.
Despite the growing interest for visualization of sentiments and emotions in textual data, the task of detecting and visualizing various stances is not addressed well by the existing approaches. The challenges associated with this task include development of the underlying computational methods and visualization of the corresponding multi-label stance classification results. In this poster abstrac
Emanuel Swedenborg (1688–1772) var en svensk naturfilosof, verksam som assessor i Bergskollegium, sedermera bibeltolkare, andeskådare och teolog. Hans kontrastrika liv, från naturvetenskap till teologi, från rationalism till mystik, från matematik till andeskådande, har förbryllat och fascinerat många. I dag är han en av de mest internationellt kända och översatta svenska författarna genom tiderna
