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Rare cancers of unknown etiology : lessons learned from a European multi-center case–control study

Rare cancers together constitute one fourth of cancers. As some rare cancers are caused by occupational exposures, a systematic search for further associations might contribute to future prevention. We undertook a European, multi-center case–control study of occupational risks for cancers of small intestine, bone sarcoma, uveal melanoma, mycosis fungoides, thymus, male biliary tract and breast. In

K. P. Moritz's case poetics : aesthetic autonomy reconsidered

To historians of medicine, Karl Philipp Moritz is known as the founding editor of the Magazine for Empirical Psychology (1783–93), one the oldest psychiatric journals in Europe. In literary theory, Moritz counts as one of the inaugurators of aesthetic autonomy. Combining both fields, this article uncovers that Moritz’s interest in observation, his reservations towards rationality, and his concern

Smoking Cessation Programs Are Less Effective in Smokers with Low Socioeconomic Status Even When Financial Incentives for Quitting Smoking Are Offered-A Community-Randomized Smoking Cessation Trial in Denmark

Financial incentives offered to those who quit smoking have been found effective, also in persons with low socioeconomic status (SES), but no previous study has investigated who benefits most: smokers with low or high SES. In this community-randomized trial ("Richer without smoking"), three Danish municipalities were randomized to reward persons who were abstinent when attending the municipal smok

Postoperative pain treatment after spinal fusion surgery : A systematic review with meta-analyses and trial sequential analyses

Patients undergoing spinal surgery are at high risk of acute and persistent postoperative pain. Therefore, adequate pain relief is crucial. This systematic review aimed to provide answers about best-proven postoperative analgesic treatment for patients undergoing lumbar 1- or 2-level fusions for degenerative spine diseases. We performed a search in PubMed, Embase, and The Cochrane Library for rand

Finger Joint Contractures 5 Years After Treatment for Dupuytren Disease : A Comparative Cohort Study of Collagenase Injection Versus Surgical Fasciectomy

Purpose: To compare collagenase injection with surgical fasciectomy in Dupuytren disease (DD) for the prevalence of contracture in treated fingers 5 years after treatment. Methods: This was a single-center, comparative cohort study comprising 2 cohorts of patients treated for DD in 1 or more of 3 ulnar fingers with collagenase injection (159 patients) or surgical fasciectomy (59 patients). At 5 ye

Why limitarianism fails on its own premises : an egalitarian critique

This article is a critical analysis of Ingrid Robeyns’ “economic limitarianism” (2017, 2019, 2022), the suggestion that there is a moral case against allowing people to be richer than they need to be in order to achieve full flourishing. Wealth above a certain “riches line” lacks value and should be capped at that level. Robeyns claims that limitarianism is justified as a partial theory of economi

The galactic scale impact of feedback from individual stars

Feedback from stars is essential for the formation and evolution of galaxies. It is an energy source that drives gas motions and chemically enriches the galaxy by supplying metals. Without this stellar feedback, numerical galaxy simulations result in galaxies with little resemblance to those observed in our Universe. Modern galaxy simulations frequently reach a mass resolution of a few tens of sol

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ZusammenfassungWir beschreiben 10 Empfehlungen für die Entwicklung szientometrischer Visualisierungenund richten uns dabei vor allem an Betreibende szientometrischer Dienste. Die Grundlagedazu bilden Nutzerstudien mit Forschenden verschiedener Disziplinen in Deutschland, welchein einen iterativen Softwareentwicklungsprozess zur Entwicklung einer szientometrischenVisualisierung im Projekt ROSI eingWe describe 10 recommendations for the development of scientometric visualisations and address primarily the operators of scientometric services. The basis for this are user studies with researchers from different disciplines in Germany, who were involved in an iterative software development process for the development of a scientometric visualisation in the ROSI project.

The h-index

The h-index is a mainstream bibliometric indicator, since it is widely used in academia, research management and research policy. While its advantages have been highlighted, such as its simple calculation, it has also received widespread criticism. The criticism is mainly based on the negative effects it may have on scholars, when the index is used to describe the quality of a scholar. The “h” mea

What lies behind altmetrics scores? Guidelines on how to use qualitative approaches in altmetrics: A report from LIBER’s Innovative Metrics Working Group

This report from LIBER’s Innovative Metrics Working Group is for those based in libraries and information centres with an interest in altmetrics who would like to know how qualitative approaches could be used to study altmetrics sources. Qualitative measures could be of interest to scholars, librarians, information professionals, and providers of research metrics and altmetrics. The topic was a ke

Human Resources Management, Internationalization and Academic Staff Mobility

In the following study (chapter 6), Human Resources Management, Internationalization and Academic Staff Mobility, Grischa Fraumann and Işıl Güney analyze the relationship between international mobility, academic staff development and human resources management. Giving some theoretical information about the role of HRM in academic staff development and academic mobility, the authors focus on intern

Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals

HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological diff

Supply chain risk management strategies in normal and abnormal times: policymakers' role in reducing generic medicine shortages

Purpose – This paper links supply chain risk management to medicine supply chains to explore the role ofpolicymakers in employing supply chain risk management strategies (SCRMS) to reduce generic medicineshortages.Design/methodology/approach – Using secondary data supplemented with primary data, the authors mapand compare seven countries’ SCRMS for handling shortage risks in their paracetamol supp

RIFM fragrance ingredient safety assessment, 4-methylpentanoic acid, CAS Registry Number 646-07-1

The existing information supports the use of this material as described in this safety assessment. 4-Methylpentanoic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-ethylbutyric acid (CAS # 88-09-5) show that 4-methylpentanoi