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The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Background: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. Methods and Findings: We used the adiposity-associated va

The importance of micrometeorological variations for photosynthesis and transpiration in a boreal coniferous forest

Plant canopies affect the canopy micrometeorology, and thereby alter canopy exchange processes. For the simulation of these exchange processes on a regional or global scale, large-scale vegetation models often assume homogeneous environmental conditions within the canopy. In this study, we address the importance of vertical variations in light, temperature, CO2 concentration and humidity within th

The effect of extremely preterm birth on attachment organization in late adolescence

Background Prior studies have examined the impact of preterm birth on the quality of the attachment relationship to the mother in infancy, but few have examined extremely preterm born infants and almost no data have been reported on prematurity and its impact on the attachment organization attained after childhood. Methods Thirty-nine adolescents born extremely preterm and 39 full-term born contro

Changes in behaviour and cytokine expression upon a peripheral immune challenge

Depression is frequently associated with inflammation. Animal studies have shown that peripheral inflammation induces depressive-like behaviour, but the underlying mechanisms remain unclear. A distinction between sickness- and depressive-like behaviour has been proposed. We hypothesize that the behavioural distinction is due to changes in the central production of immune mediators. As a model of p

Too heavy, too late: investigating perinatal health outcomes in immigrants residing in Spain. A cross-sectional study (2009-2011).

Studies have shown that immigrants residing in Spain have lower risks of delivering low birthweight (LBW) and preterm babies despite their socioeconomic disadvantages (the healthy migrant paradox). However, less is known about other important perinatal outcomes derived from birth weight and gestational age such as macrosomia and post-term birth. This paper aims to compare the main indicators relat

Opening of the abdomen ad modum Joel Cohen, Joel-Cohen, Joel Joel-Cohen, or just Cohen?

I recently bought a used book, a withdrawn ex-library copy of the second edition of Sidney Joel-Cohen's legendary textbook "Abdominal and Vaginal Hysterectomy. New Techniques Based on Time and Motion Studies" (1). The book is not only a masterpiece describing gynecological surgery techniques, my copy also has by written notes, stickers and stamps with a story to tell. The book is signed and was de

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.

PURPOSE: Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes. METHODS: Questionnaire

Human stem-cell research in gastroenterology: Experimental treatment, tourism and biobanking.

The growing interest in the possibility of applying stem-cell therapies to gastroenterological diseases is outlined. Some promising results have been reported, but more research is needed in view of the uncertainties and knowledge gaps that still exist. The ethical issues raised by this kind of research are then indicated and classified. Three problematic kinds of situation are outlined: experimen

Organizational stressors and burnout in public librarians

We investigated the relationship between organizational factors and three dimensions of burnout in a sample of 53 Swedish public librarians. We also qualitatively identified specific library-related stressors based on the organizational factors investigated. The results showed that the organizational factors workload and community predicted higher levels of emotional exhaustion while the organizat

Cosmic-ray exposure ages of fossil micrometeorites from mid-Ordovician sediments at Lynna River, Russia

We measured the He and Ne concentrations of 50 individual extraterrestrial chromite grains recovered from mid-Ordovician (lower Darriwilian) sediments from the Lynna River section near St. Petersburg, Russia. High concentrations of solar wind-like He and Ne found in most grains indicate that they were delivered to Earth as micrometeoritic dust, while their abundance, stratigraphic position and maj

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.

The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington's disease. We show in the present study that DNAJB6 also inhibits amyloid formation by an even more aggregation-prone peptide (the amyloid-beta peptide, (Aβ42)(2), implicated in Alzheimer's disease)in

Doping Incorporation in InAs nanowires characterized by capacitance measurements

Sn and Se doped InAs nanowires are characterized using a capacitance-voltage technique where the threshold voltages of nanowire capacitors with different diameter are determined and analyzed using an improved radial metal-insulator-semiconductor field-effect transistor model. This allows for a separation of doping in the core of the nanowire from the surface charge at the side facets of the nanowi

On Women's Ambivalence about Mammography Screening: Support in the Decision-Making Process a Potential Role for Health Care Social Workers?

The aim of this article is to reach a deeper understanding of women's decision-making process regarding non-attendance at mammography screenings. The article also discusses the health care social workers' role in providing support to women during this decision. Eighteen qualitative semi-structured interviews were conducted with women who had abstained from mammography screening in Malmö, Sweden. T

Cognitive restructuring and acceptance: an empirically grounded conceptual analysis

The study explores the constructs of cognitive restructuring and acceptance using items from well-established measures of the respective constructs in order to determine what subcategories or conceptual nuances that could be empirically detected, and examines these factors’relationship to each other and to positive and negative emotionality, quality of life and clinical status. The design of the s

Remote nocturnal bird classification by spectroscopy in extended wavelength ranges

We present optical methods at a wide range of wavelengths for remote classification of birds. The proposed methods include eye-safe fluorescence and depolarization lidar techniques, passive scattering spectroscopy, and infrared (IR) spectroscopy. In this paper we refine our previously presented method of remotely classifying birds with the help of laser-induced beta-keratin fluorescence. Phenomena

Female farming. Persistence and economic performance of Swedish widows from 1730-1860

This article examines the economic consequences of widowhood and the possibility of maintaining female-managed farms in a predominantly male world. A unique dataset is exploited to investigate the productivity of female-headed households in preindustrial Sweden. The main source material is tithe payment rolls maintained by parish priests, which reflect fluctuations and long-term trends in the annu

Global health education in Swedish medical schools.

Global health education is increasingly acknowledged as an opportunity for medical schools to prepare future practitioners for the broad health challenges of our time. The purpose of this study was to describe the evolution of global health education in Swedish medical schools and to assess students' perceived needs for such education.

The Dynamics of Downsizing: The Swedish Tobacco Monopoly in the 1920s

The aim of this article is to clarify and discuss the various ways firms can make workforce reductions. How do managers perceive the options for downsizing and why do they implement a particular mix of measures before another? These questions are addressed in relation to the downsizing process undertaken in the 1920s by the Swedish Tobacco Monopoly, a state-owned company that had to balance betwee