Glucagon-like peptide 1 (GLP-1), secreted from intestinal L cells, glucose dependently stimulates insulin secretion from β-cells. This glucose dependence prevents hypoglycemia, rendering GLP-1 analogs a useful and safe treatment modality in type 2 diabetes. Although the amino acid glutamine is a potent elicitor of GLP-1 secretion, the responsible mechanism remains unclear. We investigated how GLP-

Background: There is very little research on the parent's experiences of having a child admitted to a paediatric intensive care unit. Identifying and describing ‘such experiences’ could facilitate better parental support from the paediatric intensive care team and help the parents manage a stressful situation. Aims: This study aimed to describe parents' experiences of having their child admitted t

The randomised phase III clinical trial Checkmate-214 showed a survival superiority for the combination of ipilimumab and nivolumab when compared with the previous standard of care in first-line metastatic/advanced clear cell renal cell carcinoma (RCC) (Escudier B, Tannir NM, McDermott DF, et al. CheckMate 214: efficacy and safety of nivolumab plus ipilimumab vs sunitinib for treatment-naïve advan

This study examines possible crosslinguistic influence on basic word order processing in a second language (L2). Targeting Swedish V2 word order we investigate adult German learners (+V2 in the L1) and English learners (-V2 in the L1) of Swedish who are matched for proficiency. We report results from two offline behavioural tasks (written production, metalinguistic judgements), and online processi

Relying on a quantitative survey (n= 1497) and semi-structured interviews (n= 30) conducted in the U.K., we explore British nationals’, Romanian and Turkish migrants’ attitudes of tolerance and the factors influencing them in the current socio-political context in the U.K. The quantitative data reveal the role of younger age, diverse networks, higher education, attachment to city/region and supran

Political instability the last decades has forced millions of people to migrate from their homelands. In Sweden today, 1.6 million are born abroad, of which the largest immigrant groups originate from the Middle East. Immigrants from these areas represent high risk populations for type 2 diabetes with prevalence of type 2 diabetes twice as high compared to the native Swedish population. The mechanPolitical instability the last decades has forced millions of people to migrate from their homelands. In Sweden today, 1.6 million are born abroad, of which the largest immigrant groups originate from the Middle East. Immigrants from these areas represent high risk populations for type 2 diabetes with prevalence of type 2 diabetes twice as high compared to the native Swedish population. The mechan

Journal of Thrombosis and Haemostasis Supplement 1(3): abstract 0204. DOI: 10.1111/j.1538-7836.2005.03001.x

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mit

J Thromb Haemostas 2009;7(Suppl2): abstract 721. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices allow for electrophysiological recordings typically up to 12 hours. To enable longer time to test novel treatment strategies such as, e.g.,

In this study, electrospinning has been employed to produce micro to nano scale fibres of whey protein in order to investigate their potential for use in the food industry. Initially, spinning of pure whey protein proved challenging; so in order to facilitate the spinning of freshly prepared aqueous solutions, small amounts of polyethylene oxide (as low as 1% w/w in solution) were incorporated in

This article takes stock of the world's largest low-carbon technology demonstration programme – the EU's NER 300. The programme has been marked by delays and many withdrawn projects since becoming operational in 2010: CCS projects have failed and not reached final investment decisions; wind and solar projects have succeeded, whereas bioenergy projects have seen successes as well as failures. These

In the article I investigate the differences between Ansel Adams' and Jerry Uelsmann's use of nature in their respective photography. Through their attitudes, approaches to, and involvement with nature their different relations to the photographic medium and the creative process unfold. Uelsmann's departure from the straight photographic tradition - that Ansel Adams came to symbolize - is in the a

To improve the identification and separation of leptons in the Hadron Calorimeter of DELPHI, one of the four LEP experiments at CERN, the possibility of a direct read-out of the cathodes of the 20,000 limited streamer tubes was studied and successfully tested on a small scale. A larger scale test started in June 1994. This new system which is independent of the present pad read-out provides a “yes

Ischemic stroke and traumatic brain injuries (TBI) are leading causes of disability and death worldwide. Both injuries result in regional cell death and disruption of local and remote functional neuronal networks, leading to loss of neurological function. Despite much effort spent on developing pharmacological therapies to reduce neuronal damage following these conditions, no neuroprotective strat