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A Modified Phase-Field Fracture Model for Simulation of Mixed Mode Brittle Fractures and Compressive Cracks in Porous Rock

In this work, we propose a modified phase-field model for simulating the evolution of mixed mode fractures and compressive driven fractures in porous artificial rocks. For the purpose of validation, the behaviour of artificial rock samples, with either a single or double saw cuts, under uniaxial plane strain compression has been numerically simulated. The simulated results are compared to experime

Development of the form and meaning of defmiteness in Russian-speaking learners of Swedish

The study investigates the development of defmiteness in two groups of Russian-speaking learners of Swedish, one beginner group and one more advanced group. While Russian does not have articles, Swedish expresses defmiteness through a complex noun-phrase (NP) structure. Using an oral elicitation task, the study examines the learners' ability to produce morphemes that encode (in)defmiteness, their

Steering green buses : The opportunities and challenges of introducing renewable fuel in public transport

The aim of this thesis is to compare and analyse the introduction of renewable fuel in the public transport sector, focusing on the challenges and opportunities encountered by involved stakeholders on the regional and local levels. The results contribute to answering three research questions: 1) How do organisational factors and local and regional contextual factors influence the introduction of r

Comorbidity of Geo-Helminthes among Malaria Outpatients of the Health Facilities in Ethiopia: Systematic Review and Meta-Analysis

Background: Coinfection of malaria and intestinal helminths affects one third of the global population, largely among communities with severe poverty. The spread of these parasitic infections overlays in several epidemiological locations and the host shows different outcomes. This systematic review and meta-analysis determine the pooled prevalence of malaria and intestinal helminthiases coinfectio

Derivation of non-lymphopenic BB rats with an intercross breeding

Previous studies have suggested that the development of diabetes in the BB rats does not require the expression of T lymphopenia. In order to derive non-lymphopenic diabetic rats and define the relationship between the T cell abnormalities, MHC genotype, and diabetes, we performed a cross between BB/H and diabetes resistant BB/control followed by an intercross of the F1. In the F2, the overall inc

Herglotz functions and applications in electromagnetics

Herglotz functions inevitably appear in pure mathematics, mathematical physics, and engineering with a wide range of applications. In particular, they are the pertinent functions to model passive systems, and thus appear in modeling of electromagnetic phenomena in circuits, antennas, materials, and scattering. In this chapter, we review the basic theory of Herglotz functions and its applications t

Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children

Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10% of newly-diagnosed patients have an affected first degree relative. The Swedish Childhood Diabetes Register identifies 99% of all diabetic children at diagnosis. In this population-based study, islet cell antibodies and insulin autoantibodi

Enabling social participation for older people : The content of reablement by age, gender, and level of functioning in occupational therapists’ interventions

Background: Social participation and the ability to build and maintain social relationships is emphasized as important for older people’s health and well-being. Aim: To explore if social participation is addressed and whether age, gender and level of functioning are associated with the composition of occupational therapy interventions within the context of reablement. Method: In this cross-section

Matching on action : Effects of action speed and viewpoint on perceived continuity across match-action film edits

A match-action cut in feature films connects two shots of a single continuous movement. This type of editing often goes unnoticed and is arguably the most effective form of continuity editing. However, the literature offers little agreement on editing best practice and, by implication, on how our perceptual system deals with disjointed moving images. Studies have suggested that frames should overl

Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP : Five-year follow-up of the NordCML007 study

Objectives: Treatment-free remission (TFR) has emerged as a treatment goal in chronic myeloid leukemia in the chronic phase (CML-CP). Attempts to increase proportion of patients achieving TFR include combination of tyrosine kinase inhibitors (TKI) and other drugs. Interferon-α in addition to TKI has shown promising efficacy but with dose-dependent toxicity and discontinuations. NordCML007 was init

Regulation of glutamic acid decarboxylase diabetes autoantigen expression in highly purified isolated islets from Macaca nemestrina

Macaca nemestrina, which may have larger and more numerous pancreatic islets than other species, was used for large scale islet isolation by ductal collagenase perfusion and Ficoll gradient centrifugation. The average yield was 51,000 islet equivalents per pancreas, or 8,750 islets equivalents per g. The average purity was 91%, often exceeding 95%. These are the highest reported size, purity, and

A report on influences from superfluid turbulence in Der Rufer for percussion quartet

This report will discuss the influence of research into superfluid turbulence on my composition Der Rufer for percussion quartet. Written for Professor Olaf Tzschoppe, director of the Bremen Percussion Quartet, this work is the first result of a planned long-term collaboration with J.G. Weisend II, a Deputy Head of Accelerator Projects at the European Spallation Source (E.S.S.).

High level of concordance between assays for glutamic acid decarboxylase antibodies : The First International Glutamic Acid Decarboxylase Antibody Workshop

Glutamic acid decarboxylase antibodies (GADAbs) are being increasingly used in clinical and research programs for the prediction and classification of insulin-dependent diabetes mellitus (IDDM). A number of different assay formats for the measurement of GADAbs have been reported, but the degree of concordance between assays is unknown. In this study, GADAbs were measured on 16 coded sera in 34 ass

The Alterations of Mitochondrial Function during NAFLD Progression : An Independent Effect of Mitochondrial ROS Production

The progression of non-alcoholic fatty liver (NAFL) into non-alcoholic steatohepatitis implicates multiple mechanisms, chief of which is mitochondrial dysfunction. However, the sequence of events underlying mitochondrial failure are still poorly clarified. In this work, male C57BL/6J mice were fed with a high-fat plus high-sucrose diet for 16, 20, 22, and 24 weeks to induce NAFL. Up to the 20th we

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Parkinson's Disease (PD) is a neurodegenerative disorder affecting more than 10 million people worldwide. Currently, PD has no cure and no early diagnostics methods exist. Mitochondrial dysfunction is presented in the early stages of PD, and it is considered an important pathophysiology component. We have previously developed mitochondria-targeted hydroxycinnamic acid derivatives, presenting antio