Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat to our health, social and economic systems. Although vaccines have been developed in a tour-de-force and are now increasingly available, repurposing of existing drugs has been less successful. There is a clear need to develop new drugs against SARS-CoV-2 that can also be used against future coronavirus infectio

Dwarf birch (Betula nana L.), a dominant deciduous dwarf shrub in many tundra ecosystems, is predicted to increase substantially in abundance due to climate warming. Potential warming-induced changes in the concentrations of phenolic compounds in B. nana leaves could influence the susceptibility of B. nana to environmental stresses; however, only a few studies have investigated the effects of clim

Selective herbivory of palatable plant species provides a competitive advantage for unpalatable plant species, which often have slow growth rates and produce slowly decomposable litter. We hypothesized that through a shift in the vegetation community from palatable, deciduous dwarf shrubs to unpalatable, evergreen dwarf shrubs, selective herbivory may counteract the increased shrub abundance that

Previous studies have offered strong evidence that grazers alter the vegetation composition and ecosystem carbon (C) balance in ecosystems. In Arctic peatlands, however, the role of grazing has remained largely uninvestigated. Falk et al (2015 Environ. Res. Lett. 10 045001) showed that grazing by muskoxen in a high Arctic mire significantly affected both the vegetation and release of greenhouse ga

Arctic tundra currently stores half of the global soil carbon (C) stock. Climate warming in the Arctic may lead to accelerated CO 2 release through enhanced decomposition and turn Arctic ecosystems from a net C sink into a net C source, if warming enhances decomposition more than plant photosynthesis. A large portion of the circumpolar Arctic is grazed by reindeer/caribou, and grazing causes impor

Archaeological 3D GIS provides archaeologists with a guide to explore and understand the unprecedented opportunities for collecting, visualising and analysing archaeological datasets in three dimensions.With platforms allowing archaeologists to link, query and analyse in a virtual, georeferenced space information collected by different specialists, the book highlights how it is possible to re-thin

The Tobii Pro TX300 is a popular eye tracker in developmental eye-tracking research, yet it is no longer manufactured. If a TX300 breaks down, it may have to be replaced. The data quality of the replacement eye tracker may differ from that of the TX300, which may affect the experimental outcome measures. This is problematic for longitudinal and multi-site studies, and for researchers replacing eye

Experimentally determined vitamin degradation kinetic parameters are vital input for process optimization, e.g., of nutrient rich beverages such as milk and fruit juices. The standard method of obtaining these parameters is to subject a test-tube of the nutrient (in its food matrix) to a water bath at elevated temperatures and measure remaining concentration as a function of time. It is well known

Objective: We describe real-world evidence (RWE) from the nationwide Swedish and Danish registries that provide important information on incidence and outcome in multiple myeloma (MM). Method: First line treatment data on more than 10.000 MM patients from Denmark and Sweden between 2005–2018 are presented. Key results from research conducted within the Swedish and Danish myeloma registries are sum

The structural set-up and key characteristics of regulatory regimes for risk management vary between countries, technical domains and application areas. Risk regulations come in different forms, ranging from a highly prescriptive (“hard”) approaches including explicit requirements on key risk management components, to “softer” approaches requiring risk to be managed without defining how. Risk regu

After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where

Under 1980-talet började flera svenska kommuner etablera en sekundär bostadsmarknad, där socialtjänsten hyrde ut lägenheter i andra hand till hemlösa klienter som var utestängda från den ordinarie bostadsmarknaden. Orsaken var en kombination av fastighetsägares ”höga trösklar”, socialtjänstens behov av boenden för hemlösa klienter och båda parters strävan efter kontroll. Möjligheten att tilldelas

Objectives: Christmas holidays have been associated with the highest incidence of myocardial infarction (MI). We wanted to assess possible triggers of MI during Christmas. Design: A nationwide, retrospective postal survey with case-control design. All individuals suffering an MI during the Christmas holidays 2018 and 2019 in Sweden were identified through the SWEDEHEART registry and a control grou

Denna studie är en bred genomlysning av socionomfältets dimensioneringsaspekter utifrån ett sammanhållet perspektiv där arbetsmarknadsutsikter, utbildningsfrågor och kompetensfrågor belyses dels var för sig men måste också relateras till varandra. Lärosätenas dimensionering av såväl grundutbildning som vidareutbildning måste ses i relation till arbetsmarknadens föränderliga behov av högskoleutbild

Background: Vaccine effectiveness against COVID-19 needs to be assessed in diverse real-world population settings. Methods: A cohort study of 805,741 residents in Skåne county, Southern Sweden, aged 18–64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. Incidence rates of COVID-19 were estimated in sex- and age-adjusted analysis and stratified in two-week periods with subs