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Importance: General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They involve risks for patients, but to estimate these, more data are needed. Objective: To develop a more precise overview of the rate at which
A majority of all infectious diseases manifest some climate-sensitivity. However, many of those sensitivities are not well understood as meteorological drivers of infectious diseases co-occur with other drivers exhibiting complex non-linear influences and feedback. This makes it hard to dissect their individual contributions. Here we apply a novel deep learning Explainable AI (XAI) compartment mod
It is a continued open question how there can be an azimuthal anisotropy of high p⊥ particles quantified by a sizable v2 in p+Pb collisions when, at the same time, the nuclear modification factor RAA is consistent with unity. We address this puzzle within the framework of the jet quenching model Jewel. In the absence of reliable medium models for small collision systems we use the number of scatte
INTRODUCTION: Social prescribing (SP) is an innovative model that connects individuals to non-clinical community resources. However, its uptake and evaluation have been hindered by inconsistent role definitions for key stakeholders. Although recent studies have refined SP definitions, outside the UK, the responsibilities, educational backgrounds and training requirements of social prescribing link
Highlights: What are the main findings? Health for adolescents with depression was described in terms of managing everyday life, building confidence and trust, experiencing joy in life, and supporting well-being. These aspects reflect how health can be understood through daily routines, relationships, emotional experiences, and lifestyle habits. What is the implication of the main finding? The fin
This study examines the impact of grammatical gender on memory recall among simultaneous bilinguals with two three-gendered languages (Ukrainian and Russian). Ukrainian-Russian bilinguals and English monolingual controls were tested on their ability to remember names assigned to objects with either matching or mismatching grammatical genders across their two languages. Results showed that bilingua
Background: The long-term impact of asthma on mortality remains uncertain. This study aimed to assess mortality and its predictors over 26 years in asthmatic participants compared to those with or without other respiratory symptoms. Methods: This longitudinal cohort study included participants recruited from the general Swedish population, followed from 1990 to 2016. The younger (30–39 years, n =
Group exhibition.With beyond now. Editions, the Kestner Gesellschaft reflects on its exhibition history and the connection between artistic production and institutional work. This special exhibition includes both current and rediscovered limited-edition works, combining them with a series of related exhibition posters. A visual timeline traces the historical context of the works, their thematic co
In recent years, there has been a growing scholarly interest in the cultural and political significance of joyful, positive and nostalgic memories and forms of remembrance. Without downplaying the role of trauma and oppression in the mnemonic makeup of contemporary societies, memory scholars have increasingly pointed to the co-existence, or parallel existence, of brighter recollections of the past
Anticipation entails contemplating the beneficial and harmful impacts of scientific and technological progress. Anticipation has a long history in science, technology, and innovation policy partly due to future impacts of scientific progress being inescapable. The link between anticipation, an undertheorized concept, and human rights law is yet to be fully explored. This paper links anticipation t
In an article in this journal, Katherine Drabiak argues that green lighting genome editing of human embryos is contrary to "fundamental human rights law." According to the author, genome editing of human embryos violates what we should recognize as a fundamental human right to inherit a genome without deliberate manipulation. In this reply article, we assess Drabiak's legal analysis and show metho
This article uses empirical investigation of regional hydrogen investments and strategies in Northern Europe to develop a new conceptual approach to regional industrial path development which foregrounds politics and power as explanatory factors in understanding the logics, processes and outcomes of path development. This conceptualisation departs from Evolutionary Economic Geography approaches to
Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati
The Human Right to Science is about the “human right to benefit from progress in science and its applications,” also known more succinctly as the “right to science.” Although the right to science is one of the oldest internationally recognized human rights, it has suffered too long from neglect. International organizations and States pay little attention to it. There are only a few inadequate indi
Advances in quantum computing pose a fundamental threat to classical public-key cryptosystems, including RSA and elliptic-curve cryptography (ECC), which form the foundation for authentication and key exchange in the Transport Layer Security (TLS) protocol. In response to these emerging threats, Korea launched the KpqC (Korea Post-Quantum Cryptography) project in 2021 to design, evaluate, and stan
Background/Objectives: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection. Mitochondrial dysfunction is considered a key contributor to the pathogenesis of sepsis, but its molecular mechanisms remain unclear. Methods: In this study, we used a cecal ligation and puncture (CLP) model to induce sepsis in wild-type (WT) and cyclop
Introduction: Non-suicidal self-injury (NSSI) is often met with stigma, which can deter individuals from seeking help. While most research on NSSI stigma has focused on clinical settings, the attitudes of those most likely to receive an NSSI disclosure, such as peers, friends, and family, remain underexplored. Building on qualitative findings that positive disclosure experiences can foster support
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio
People often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosociaPeople often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosocia
Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a critical-size ulnar defect model in nonhuman primates. Methods: In cynomolgus monkeys (N = 22, male, 10–12 year
