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Urbanisation-associated shifts in the avian metabolome within the annual cycle

While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism

Multispecies synbiotics alleviate dextran sulfate sodium (DSS)-induced colitis : Effects on clinical scores, intestinal pathology, and plasma biomarkers in male and female mice

Background: Inflammatory bowel disease (IBD) is characterized by recurrent inflammation of the gastrointestinal tract and has been linked to an imbalance in gut bacteria. Synbiotics, which combine probiotics and prebiotics, are emerging as potential IBD treatments. Aim: To examine the effects of four synbiotic formulations on intestinal inflammation and peripheral biomarkers in a rodent IBD model

Are we using more sugar substitutes? Wastewater analysis reveals differences and rising trends in artificial sweetener usage in Swedish urban catchments

The market for artificial sweeteners as substitutes for conventional sugar (sucrose) is growing, despite potential health risks associated with their intake. Estimating population usage of artificial sweeteners is therefore crucial, and wastewater analysis can serve as a complement to existing methods. This study evaluated spatial and temporal usage of artificial sweeteners in five Swedish communi

Study of Z→llγ decays at s = 8 TeV with the ATLAS detector

This paper presents a study of Z→llγ decays with the ATLAS detector at the Large Hadron Collider. The analysis uses a proton–proton data sample corresponding to an integrated luminosity of 20.2 fb-1 collected at a centre-of-mass energy s = 8 TeV. Integrated fiducial cross-sections together with normalised differential fiducial cross-sections, sensitive to the kinematics of final-state QED radiatio

In-depth proteomic analysis and structural modelling of protein-protein interactions identify known and novel molecular binding partners for EMP3 in erythroid cells

Background: The absence of Epithelial Membrane Protein 3 (EMP3) on red blood cells (RBCs) underlies the MAM-negative (MAM−) phenotype. EMP3 is a ubiquitous protein found at low levels in most tissues but with higher expression in hematopoietic cells. Low levels of CD44 are a signature of MAM− RBCs due its proposed physical interaction with EMP3, indicating that EMP3 stabilises CD44 in the membrane

Search for Nearly Mass-Degenerate Higgsinos Using Low-Momentum Mildly Displaced Tracks in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector

Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1 GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse imp

Variability of polygenic prediction for body mass index in Africa

Background: Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent. Studies to understand the factors that affect PRS variability within Africa are required. Methods: Using the first multi-ancestry genome-wide associa

Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care

Background: As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical and functional Health Assessment Tool (HAT) based on four cohorts of older adults (60 + years) from the Swedish National study on Aging and Care (SNAC) spanning urban, suburban, and

Impact of final design on daylight provision

Daylight analysis informs design decisions in architectural spaces, yet materials, colours, and furnishings - often chosen later - can significantly impact indoor daylighting. This study assessed these effects in a typical open-plan office in Copenhagen using parametric simulations with Radiance through Honeybee in Grasshopper, complemented by a sensitivity analysis following the Morris method. Va

Linking grandiose and vulnerable narcissism to managerial work performance, through the lens of core personality traits and social desirability

While grandiose narcissism is well-studied, vulnerable narcissism remains largely unexplored in the workplace context. Our study aimed to compare grandiose and vulnerable narcissism among managers and people from the general population. Within the managerial sample, our objective was to examine how these traits diverge concerning core personality traits and socially desirable responses. Furthermor

Accuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging

Purpose: This study aimed to assess the accuracy of patient-specific absorbed dose calculations for tumours and organs at risk in radiopharmaceutical therapy planning, utilizing hybrid planar-SPECT/CT imaging. Methods: Three Monte Carlo (MC) simulated digital patient phantoms were created, with time-activity data for mIBG labelled to I-123 (LEHR and ME collimators) and I-131 (HE collimator). The s

Words of analytic paraproducts on Hardy and weighted Bergman spaces

For a fixed analytic function g on the unit disc, we consider the analytic paraproducts induced by g, which are formally defined by Tgf(z)=∫0zf(ζ)g′(ζ)dζ, Sgf(z)=∫0zf′(ζ)g(ζ)dζ, and Mgf(z)=g(z)f(z). We are concerned with the study of the boundedness of operators in the algebra Ag generated by the above operators acting on Hardy, or standard weighted Bergman spaces on the disc. The general question

Retrograde cerebral perfusion reduces embolic and watershed lesions after acute type a aortic dissection repair with deep hypothermic circulatory arrest

Background: To assess whether retrograde cerebral perfusion reduces neurological injury and mortality in patients undergoing surgery for acute type A aortic dissection. Methods: Single-center, retrospective, observational study including all patients undergoing acute type A aortic dissection repair with deep hypothermic circulatory arrest between January 1998 and December 2022 with or without the

Weimarrepubliken - hisnande, bruten : Recension av Harald Jähner: Vertigo: The Rise and Fall of Weimer Germany 1918-1933

Weimarrepubliken, den demokratiska parentesen mellan Andra och Tredje tyska riket, representerar en av de politiskt mest dramatiska och kulturellt mest dynamiska episoderna i den europeiska 1900-talshistorien. Republiken kunde, om den fått leva, ha lett världshistorien i helt andra och ljusare banor. Mycket har med fog genom åren skrivits om den och nu har ett stort arbete sett dagens ljus med den

A multidomain PARP14 construct suitable for bacterial expression

Poly-ADP-ribose polymerase-14 (PARP14) can modify proteins and nucleic acids by the reversible addition of a single ADP-ribose molecule. Aberrant PARP14 functions have been related to cancer and inflammation, and its domains are involved in processes related to viral infection. Previous research indicates that PARP14 functions might be mediated via a multitude of target proteins. In vitro studies