Recent decades have witnessed an innovation in genetics and biomedical practices, shifting the practice from treatment to prevention. Testing healthy individuals for genetic inherited diseases has now become increasingly common, preventing potential disease by offering early screenings, medication, or potentially surgery, reducing the genetic risk from developing into disease. Though, social scien

Extreme weather events, such as heatwaves and cold spells, are predicted to increase under climate change, which can have significant negative effects on fitness and survival of wildlife. If such variations are timed during development, they can affect growth and subsequent performance in birds, with influence over long-term temperature tolerance. Developmental temperature can also have direct eff

Sniffing out friends and foes: Bark beetle larvae and fungal scents. A tiny but destructive force is threatening Eurasian forest habitats – the Eurasian spruce bark beetle, Ips typographus. The larvae of this beetle species develop under the bark of conifers and feed on tree tissue. This leads to tree death and thus widespread devastation in wooded landscapes. The beetles live in partnership wit

Samverkande proteiner vid syrebrist under inflytande av inhibitorn PT2385 i hjärntumörceller från barn DIPG är en typ av hjärncancer hos barn som är placerad i övre delen av nacken vilket gör den svår att operera. Ledsamt nog finns ingen behandling för denna sjukdom, och patienter behandlas ofta med strålning för att förlänga livet med några enstaka månader. Hos den typiska patienten så överlevePurpose: The HIF-2α inhibitor PT2385 inhibits complex formation between HIF-2a and ARNT1 and thereby blocks HIF-2a transcriptional activation. It has been proven to extend survival in renal cancer, while its effects in pediatric brain cancer are unknown. This study is to investigate the effect of PT2385 in diffuse intrinsic pontine glioma (DIPG) cells, as well as to investigate HIF-2a interaction

Emotionellt arbete är ett begrepp som innebär den känsloreglering en individ gör för att leva upp till olika situationers förväntade beteenden och uttryck. Sker detta inom en yrkesroll så är det ett emotionellt lönearbete. Forskning har visat att denna känsloreglering, som innebär både att förstärka vissa känslor och förtrycka andra, kan vara skadligt för en individ som utövar detta under en längr

Investigating the Mechanism of Action of DNA Damage Response Inhibitors Cancer is a complex, heterogenous, systemic disease. It is considered to be a leading cause of death worldwide. Currently, there is limited treatment for this disease and the field of oncology presents the highest percentage of failed trials (32%) for drugs in phase II and phase III, mainly due to lack of efficacy or safety.

Glucose transporters, known as Gluts, play an important role in facilitating the transport of sugar across the cell membrane. Of these, 14 types are known, one of which is Glut3, which is highly expressed in the brain, testicles and nervous system. Its importance lies in the fact that it is responsible for the uptake of glucose in cells with high sugar requirements, such as neurons. Glucose uptake

Cracking the Code: Why Cancer Cells Struggle to Transform into Antigen-Presenting Dendritic Cells Since cancer is one of the leading causes of death worldwide, the possibility of converting cancer cells into other cell types represents an interesting approach to fighting cancer. Transforming cancer cells into immune cells by reprogramming their cell identity into immune cells could be a smart way

Rökextrakt och dess negativa påverkan på återvinningsprocesser i lungceller från KOL-patienter Kroniskt obstruktiv lungsjukdom (KOL) är en global folksjukdom och den tredje största dödsorsaken i världen. Den kan kopplas till en mängd andra sjukdomar och tillstånd som också ofta ökar risken för att utveckla KOL, t ex hög ålder, kardiovaskulära och neurosjukdomar. Men den största och mest välkända Chronic obstructive pulmonary disease (COPD) is the third largest cause of death worldwide, with its most prominent risk factor being inhalation of smoke and pollutants. In this project, we studied two processes that are involved in COPD: autophagy and cellular senescence. Using primary human bronchial epithelial cells (HBECs) from healthy and COPD donors, we aimed to show that cigarette smoke ext

Våra celler kommer ihåg SARS-CoV-2 Hjärt- och kärlsjukdomar är en av de ledande dödsorsakerna i världen. Ateroskleros, ett tillstånd där fett ansamlas i kärlen, har visats orsaka hjärt- och kärlsjukdomar. Flera delar av vårt immunförsvar har även visats ha ett samband med ateroskleros. En av dessa delar är det adaptiva immunförsvaret, där så kallade B- och T-celler finns. B- och T-celler ingår iAdaptive immunity has been implicated in cardiovascular diseases, but the relationship between immune capacity or immune function in these diseases has yet to be established. I optimized a method to screen for immune capacity using immune responsiveness against the SARS-CoV-2 spike protein as a proxy. This method screens for markers upregulated during activation on lymphocytes using fluorescent an