The functional efficacy of colocalized, linked protein domains is dependent on linker flexibility and system compaction. However, the detailed characterization of these properties in aqueous solution presents an enduring challenge. Here, we employ a novel, to our knowledge, combination of complementary techniques, including small-angle neutron scattering, neutron spin-echo spectroscopy, and all-at

Covered nitinol alloy self-expandable metal stents (SEMSs) have been developed to overcome the shortcomings of steel SEMS in patients with malignant biliary obstruction. In a randomized, multicenter trial, we compared stent patency, patient survival, and adverse events in patients with partly covered stents made from steel or nitinol.

PurposeAlthough precise identification of the seizure-onset zone is an essential element of presurgical evaluation, source localization of ictal electroencephalography (EEG) signals has received little attention. The aim of our study was to estimate the accuracy of source localization of rhythmic ictal EEG activity using a distributed source model. MethodsSource localization of rhythmic ictal scal

Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy is distributed between cellular compartments in photoreceptors. In avascular retinas, aerobic production of energy occurs only in mitochondria that are located centrally within the photoreceptor. Our findings indicate that metabolic energy f

The Women's Health in the Lund Area (WHILA) project (n=6917) is a cohort study that started in 1995 and includes a postal questionnaire, physical examination, bone density measurement and blood laboratory analyses. Fracture data have been added, and in this report fracture risk and its association with sex hormones was analysed in postmenopausal women without current hormone therapy (HT). A total

Drowning is a leading cause of accidental death. Survivors may sustain severe neurologic morbidity. There is negligible research specific to brain injury in drowning making current clinical management non-specific to this disorder. This review represents an evidence-based consensus effort to provide recommendations for management and investigation of the drowning victim. Epidemiology, brain-orient

In this article, we experimentally investigate the substrate, wavelength, and time dependence of the plasmon-assisted surface-catalyzed dimerization of 4-nitrobenzenethiol to form p,p'-dimercaptoazobenzene on Au, Ag, and Cu films. We provide direct experimental evidence that surface plasmon resonance plays the most important role in these surface-catalyzed reactions. It is found that the reaction

BACKGROUND: Because hemodilution decreases the oxygen-carrying capacity of blood, it was hypothesized that severe hemodilution would decrease the tolerance to alveolar hypoxia. METHODS: Hemodynamics, oxygen transport, and blood lactate concentrations were compared in ten pigs with normal hematocrit (33 +/- 4%), and ten hemodiluted pigs (hematocrit 11 +/- 1%; mean +/- SD) anesthetized with ketamine

In this paper a fully automated segmentation system for the femur in the knee in Magnetic Resonance Images and the brain in Single Photon Emission Computed Tomography images is presented. To do this several data sets were first segmented manually. The resulting structures were represented by unorganised point clouds. With level set methods surfaces were fitted to these point clouds. The iterated c

Two packed-bed bioreactors filled with carriers of foamed glass beads were tested at 14 degrees C (bioreactor RA) or at 23 +/- 1 degrees C (bioreactor RB) for the continuous treatment of a mixture of 2-chlorophenol (2CP), 4-chlorophenol (4CP), 2,4-dichlorophenol (DCP) and 2,4,6-trichlorophenol (TCP). The reactors were inoculated by mixed bacterial consortia acclimatized to the pollutants at each t

The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and one case of polycythemia vera. Recently, the t(11;20) was shown to result in a fusion of the NUP98 and TOP1 genes, with expression of the NUP98/TOP1 chimera encoded by the der(11)t(11;20), but not of th

An updated version of the spectral ( bin) microphysics cloud model developed at the Hebrew University of Jerusalem [ the Hebrew University Cloud Model (HUCM)] is described. The model microphysics is based on the solution of the equation system for size distribution functions of cloud hydrometeors of seven types ( water drops, plate-, columnar-, and branch-like ice crystals, aggregates, graupel, an

The most precise method of investigating possible space-time variations of the fine-structure constant, alpha equivalent to (1/hc)(e(2)/4 pi epsilon(0)), using high-redshift quasar absorption lines is the many-multiplet (MM) method. For reliable results this method requires very accurate relative laboratory wavelengths for a number of UV resonance transitions from several different ionic species.

Photoabsorption cross sections of sulfur dioxide over a range of temperatures are required to interpret observations and to support models of the atmospheres of Io and Venus. We report high-resolution (lambda/Delta lambda approximate to 450,000) photoabsorption cross-section measurements by Fourier transform spectrometry of SO2 at 160 K in the wavelength region 199 to 220 nm, which encompasses the

Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals identified. Here, we use a panel of human osteoblasts (HObs) to carry out a transcriptomic survey, similar to recent studies in lymphoblastoid cell lines (LCLs). The distinct nature of HObs and LCLs

Objectives. The purpose of this study was to determine the impact of iron status on cadmium dose among pregnant women. Methods. Iron status and cadmium concentration in blood, urine, and placenta were determined among women followed for 2 years from early pregnancy. Results. Blood cadmium and urinary cadmium were correlated with iron status throughout the study period. Urinary cadmium increased lo

BACKGROUND: Propofol, a popular intravenous (iv) anaesthetic induction agent for brief cases or day surgery, is associated with smooth induction, pleasant sleep, rapid recovery and little postoperative nausea. A major disadvantage is pain at the site of injection. The aim of the present study was to examine the influence of simultaneous iv infusion of carrier fluid on propofol-induced local pain.

The microbiota is part of the gastrointestinal ecosystem. A more detailed understanding should provide insight into multiple human disease states. This study investigated inflammatory bowel disease (Crohn's disease and ulcerative colitis). Previous analyses have suggested a role of gram-negative bacteria including Escherichia coli. An integrated procedure is presented where gas chromatography-mass