Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. Complex interactions of genetic and environmental factors trigger the onset of autoimmune mechanisms responsible for development of autoimmunity to β cell antigens and subsequent development of T1D. A potential role of virus infections has long been hypothesized, and growing evide

Background: Lipid metabolism plays an important role in viral infections. We aimed to assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors and NPC1L1 inhibitior) on COVID-19 outcomes using 2-sample Mendelian Randomization (MR) study.Methods: We used two kinds of genetic instruments to proxy the exposure of lipid-lowering drugs, including eQTLs of drugs target gene

Human agency has become a core topic in economic geography complementing traditional, structural approaches to explain regional development. This paper contributes firstly with a discussion of the theoretical and conceptual relationships between the agency of individuals, organizations, and systems. Secondly, it proposes a novel analytical framework for studying how human agency, combined with ext

There is over 15,600 km of track in the Swedish railroad network. This network is vital for the transportation of people and goods across the country. It is important that this network is monitored and maintained to ensure good function and safety. A tool for monitoring and measuring ground deformation over a large area remotely with high frequency and accuracy was developed in recent decades. Thi

Transurethral resection of the prostate (TURP) remains the gold standard for the surgical treatment of benign prostatic hyperplasia. Complications during the procedure are rare. An extremely rare complication is a rupture of the urinary bladder. This article reports a case where an explosion occurred during TURP, resulting in a large intraperitoneal rupture of the urinary bladder. The patient unde

The Nairobi Summit on ICPD25 provided an opportunity to complete the unfinished business of the International Conference on Population and Development Programme of Action and also a chance to commit to a forward-looking sexual and reproductive health and rights agenda to meet the Sustainable Development Goals and targets by 2030.This background document for the Nairobi Summit on ICPD25 was conceiv

Introduction: Gallbladder carcinoma is about 0.5% of all cancer. The outcome of patients with gallbladder carcinoma is overall bad and the only potentially curative treatment is surgery. The aim of this study was to determine the disease's prevalence in Iceland and outcome of the patients diagnosed in the study period.Patients and methods: This was a retrospective study of all diagnosed patients w

The environment suffers enormously during armed conflicts and, despite the increasing awareness of the pressing need to protect the planet, devastating environmental damage can occur legally at times of war. This book suggests that – apart from the protection offered under law of armed conflict – environmental treaties or multilateral agreements (MEAs) can complement and strengthen environmental p

This article aims at questioning the uses of feminist epistemologies and methodologies in the context of a fieldwork project conducted in Colombia on the return to civilian life of female combatants. While the topic « female combatants »tends to be the object of an academic over-investment, contributing to its depoliticization, the Authors discuss the various approaches, tools and methods produced

The design of buildings has mainly focused on energy performances during the last decades however, it is also important to emphasize human needs and behaviour. Our research projects aim to advance knowledge of sustainability concepts in building design by investigating how buildings communicate with users towards sustainability, how are buildings perceived and used, and the roles of the individual

The water flea Daphnia has the capacity to respond rapidly to environmental stressors, to disperse over large geographical scales, and to preserve its genetic material by forming egg banks in the sediment. Spatial and temporal distributions of D. magna have been extensively studied over the last decades using behavioral or genetic tools, although the correlation between the two has rarely been the

Past research on the effect of oxygen concentration on the heat release rate and carbon monoxide yield has focused on materials in isolation and there is a lack of research that studies end-use products. This paper investigates the effect of oxygen concentration on the heat release rate per unit area (HRRPUA) and carbon monoxide yield for two different cables and a mineral oil used as an operating

Late mortality of European 5-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed

En inspirationsbok med verktyg för att främja återhämtning under arbetsdagen – både för individ och verksamhet.

This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia Pacific Heart Rhythm Society describes the current status of mobile health (“mHealth”) technologies in arrhythmia management. The range of digital medical tools and heart rhythm disorders that they may be applied to and clinical decisi

This Movement Disorder Society Genetic mutation database Systematic Review focuses on monogenic atypical parkinsonism with mutations in the ATP13A2, DCTN1, DNAJC6, FBXO7, SYNJ1, and VPS13C genes. We screened 673 citations and extracted genotypic and phenotypic data for 140 patients (73 families) from 77 publications. In an exploratory fashion, we applied an automated classification procedure via a

Purpose: Tensor-valued diffusion encoding provides more specific information than conventional diffusion-weighted imaging (DWI), but has mainly been applied in neuroimaging studies. This study aimed to assess its potential for the imaging of prostate cancer (PCa). Methods: Seventeen patients with histologically proven PCa were enrolled. DWI of the prostate was performed with linear and spherical t