OBJECTIVES: Sedation and neuromuscular blockade protocols in patients undergoing targeted temperature management after cardiac arrest address patient discomfort and manage shivering. These protocols vary widely between centers and may affect outcomes. DESIGN: Consecutive patients admitted to 20 centers after resuscitation from cardiac arrest were prospectively entered into the International Cardia

We recently discovered the isoform selective RARβ2 ligand 4′-octyl-4-biphenylcarboxylic acid (3, AC-55649). Although 3 is highly potent at RARβ2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we describe the exploration of the SAR in a biphenyl and a phenylthiazole series of analogues of 3. This ultimately led to the design of 28, a novel, ora

Three marine bacteria were examined for physiological and morphological changes in the initial phase of starvation. It was found that the starvation process was induced in a similar way irrespective of whether the cells were suspended in nutrient and energy free artificial seawater (NSS) or NSS supplemented with nitrogen and phosphorus. An initial phase of increased activity was consistent with a

Plastics have become ubiquitous in modern society. It is a group of materials that is versatile and useful in many types of applications and have thus become extremely popular. Plastics are thus important for many industries and value chains as well as for everyday practices of most individuals – and should thus be also for investors and financial actors. A transition to sustainable plastics will

The aim of this work is the development of a thermodynamically consistent fully coupled thermo‐viscoplastic material model for metals. The model is based on a split of the free energy into a thermo‐elastic, a thermo‐plastic and a purely thermal part and covers nonlinear cold‐work hardening and thermal softening. Nonlinear temperature dependent effects are accounted for the elastic moduli, the plas

α-Galactosidases are important industrial enzymes for hemicellulosic biomass degradation or modification. In this study, six novel extracellular α-galactosidases from Penicillium subrubescens were produced in Pichia pastoris and characterized. All α-galactosidases exhibited high affinity to pNPαGal, and only AglE was not active towards galacto-oligomers. Especially AglB and AglD released high amou

Aim: Vegetation structure is a key determinant of animal diversity and species distributions. The introduction of Light Detection and Ranging (LiDAR) has enabled the collection of massive amounts of point cloud data for quantifying habitat structure at fine resolution. Here, we review the current use of LiDAR‐derived vegetation metrics in diversity and distribution research of birds, a key group f

This paper investigates the empirical relationship between countries’ expressed concerns with fairness and the ambition levels in their pledged contributions (NDCs) to the Paris Agreement, asking the following questions: 1) Are the NDCs of countries who express the most concern with fairness more or less ambitious than those of other countries? 2) Does the relationship between fairness and ambitio

The breakup of the L-chondrite parent body in the asteroid belt 466 million years (Ma) ago still delivers almost a third of all meteorites falling on Earth. Our new extraterrestrial chromite and 3He data for Ordovician sediments show that the breakup took place just at the onset of a major, eustatic sea level fall previously attributed to an Ordovician ice age. Shortly after the breakup, the flux

Reactivity N - Own: Pyridine N-oxides can be used for the complete regio- and stereoselective synthesis of trans-substituted piperidines. The sequential addition of Grignard reagents and aldehydes or ketones to pyridine N-oxides yields a complete regio- and stereoselective trans 2,3- addition reaction in high yields, and the substituted 2,3-dihydropyridine N-oxide can be reduced to form 2,3-trans-

Chemical speciation and partitioning of radiolabeled HgCl2 were studied in model aquatic systems consisting of undisturbed entrophic lake sediment and water in plastic cylinders. The cylinders were either gradually made anaerobic by a gentle flow of N2-CO2 or kept aerobic by air flow. The proportion of methylated 203Hg was significantly higher, in both water and sediment, in the anaerobic systems

Male and female flowers of the dioecious perennial herb Rubus chamaemorus L. are similar in general appearance. However, female flowers are somewhat smaller, do not produce any pollen, and contain very small amounts of nectar. Syrphids and bumblebees, which are important pollinators of R. chamaemorus, showed a strong preference for male flowers. Male flowers were also less often rejected by flower

Beta-haemolytic streptococci (BHS) are important causes of human infections and they have traditionally been grouped according to Lancefield antigens. The spectrum of infections caused by BHS includes pharyngitis, skin infections, bacteraemia/sepsis, endocarditis, septic arthritis and meningitis. The most studied BHS is the group A Streptococcus (GAS), which concurs with the species Streptococcus

Background Screening accuracy can be improved with digital breast tomosynthesis (DBT). To further evaluate DBT in screening, it is important to assess the molecular subtypes of the detected cancers. Purpose To describe tumor characteristics, including molecular subtypes, of cancers detected at DBT compared with those detected at digital mammography (DM) in breast cancer screening. Materials and Me

This study focuses on quantitative long-term effects of Supplemental Instruction (SI) in terms of graduation and dropout rates. One of the main aims of SI is to introduce students to effective study strategies and techniques. If SI is introduced at an early stage for new students in higher education, it should therefore be expected that this action will promote timely graduation. This has also beeThis study focuses on quantitative long-term effects of SupplementalInstruction (SI) in terms of graduation and dropout rates. One of the main aimsof SI is to introduce students to effective study strategies and techniques. If SIis introduced at an early stage for new students in higher education, it shouldtherefore be expected that this action will promote timely graduation. This hasalso been ind

Kartor används, cirkuleras och erkänns och har därmed konsekvenser för hur människor uppfattar världen. Kartor förmedlar politiskt meningsskapande och sätter ramar för vilka politiska alternativ som får komma till tals eller som tystas ned. Till skillnad från dominerande tillvägagångssätt för att studera makten hos kartor, som betraktar kartors politiska inflytande utifrån kartproducentens avsikteAs maps are widely used, circulated, and recognised, they have consequences for how people view and understand the world. They mediate political meaning-making and frame the conditions for political alternatives to emerge or to be silenced. In contrast to dominant approaches to the study of the power of maps that consider their political influence on the basis of the intentions of the map-maker, t