The CD40-CD40L interaction plays a critical role in both humoral and cellular immune responses and interfering antibodies have been suggested as an effective approach for the treatment of lymphomas and autoimmune diseases. In this study we have profiled a panel of mouse antihuman CD40 monoclonal antibodies (MoAbs), regarding their CD40 binding affinity and epitope-specificity relative to the CD40L

The concept of measure functions for classifier performance is suggested. This concept provides an alternative way of selecting and evaluating learned classifiers, and it allows us to define the learning problem as a computational problem.

Based on the known age-related loss of Purkinje cells (PC) in the cerebellum, this study focuses on whether a marked loss of PC occurs in individuals of very high age. The inferior olive, which is intimately connected with the cerebellum anatomically as well as functionally, was also studied. The study group included 15 nondemented and basically healthy cases aged 32-104 years. Linear neuronal den

Popular Abstract in Swedish En omorganisation av det svenska Vägverket har medfört ett behov för dem att fungera som en professionell beställare enbart, utan utförande i egen regi. Det har naturligtvis också medfört en förändring i hur man hanterar upphandlingen av vägunderhåll. En väghållares främsta uppgift är att underhålla befintliga anläggningar och se till at de fungerar som avsett. Den näsA reorganization of the Swedish National Road Administration (SNRA) has urged a demand to work as a professional agency only, without any work by direct labor. This structure has enforced a change in how to handle the pavement maintenance and performance contracts are being promoted since they encourage product development and sustainability. Furthermore, SNRA desires to use the road network as a

We examined the physical and social function of patients surviving 10 years after internal fixation of a hip fracture. 74 out of 362 patients were alive 10 years after their fracture. In 47 survivors after cervical fracture, secondary hip arthroplasties had been performed in 25, and nails had been extracted in 13. The implants had been removed in 8 of 27 with trochanteric fracture. 58 survivors we

Samlingsrecension av av Torbjörn Nilsson & Øystein Sørensen (red.), Goda grannar eller morska motståndare? Sverige och Norge från 1814, Klas Åmark, Hundra år av välfärdspolitik. Välfärdsstatens framväxt i Norge och Sverige, Torbjörn Nilsson & Øystein Sørensen (red.), 1905 – Unionsupplösningens år. Nya perspektiv på ett svensk-norskt drama; Francis Sejersted, Socialdemokratins tidsålder. Sv

Exhaust emissions from lean burn natural gas engines may not always be as low as the potential permits, especially engines with open-loop lambda control. These engines can produce much higher emissions than a comparable diesel engine without exhaust gas aftertreatment. Even if the engine has closed-loop lambda control, emissions are often unacceptably high for future emission regulations. A three-

Six new species: Caloplaca kalbiorum and C. epiborya from Western Australia, Fulgensia cranfieldii from Western Australia, South Australia and Victoria, Xanthoria coomae occurring in several states on the continent, and X. hypogymnioides and X. whinrayi from Tasmania are described and illustrated. The new combination Caloplaca pulcherrima is proposed and recorded for the first time for New Zealand

Till skillnad från den nazistiska eugeniken alstras den genteknologiska av marknadskrafterna. Mot efterfrågan på eliminering av t ex sjukdomsgener svarar transnationella företags privatisering av det mänskliga genetiska arvet via patentering av livsformer. Det är hög tid att analysera de omvälvande sociala och politiska följderna av denna bio-ekonomiska utveckling.

Background. The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-based study over a long period of years. Methods. The prenatal diagnoses are com

Quantitative measurements of the effects of irradiation on normal tissues in humans have been hard to obtain because most tissues are inaccessible and/or direct responses are difficult to quantify in a nondestructive manner. Pneumonitis and fibrotic lung disease are adverse effects seen in varying intensity in patients treated with radiotherapy for carcinomas of the thorax, e.g., breast cancer. In