Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index
Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI).