Objective: The purpose of this study was to determine, using a top-down genetic analysis, the degree of specificity of the genetic risk factors for individual forms of substance use disorders (SUD). Method: We examined and followed to December 31, 2018, all individuals born in Sweden between 1960 and 1990 (N = 2,772,752) diagnosed with any of the following six SUDs: alcohol use disorder (AUD), dru

Acetaminophen and ibuprofen are widely used over-the-counter medications to reduce fever, pain, and inflammation. Although both drugs are safe in therapeutic concentrations, self-medication is practiced by millions of aged patients with comorbidities that decrease drug metabolism and/or excretion, thus raising the risk of overdosage. Mitochondrial dysfunction has emerged as an important pathomecha

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but serious complication after a pulmonary embolism. Healthcare resource utilization (HCRU; hospitalization, outpatient visits, and drug utilization) as well as productivity loss (sick leave and disability pension) before and after the CTEPH diagnosis is sparsely studied. By linking several Swedish national databases, this study estim

Shape control strategies seek to bring deformable objects towards a desired target shape. However, conventional methods focus on reaching the target shape without considering the extent to which the object is deformed during the control process. Control actions may generate unnecessary deformations and thus, increase the possibility of object over-stressing and failure. In this letter, we tackle t

The restaurant industry in increasingly aware of sustainability issues with around 34% of anthropogenic greenhouse gas emissions come from life-cycle stages in food systems and increased concerns over packaging and food waste. The Michelin Restaurant Guide has awarded the distinction of a Green Star to restaurants at the forefront of the industry in their sustainability. However, although restaura

Closed-loop motion planning is suitable for obstacle avoidance in dynamically changing environments due to its reactive nature, and various methods have been presented to provide (almost) global convergence. A common assumption in the control design is that the robot operates in a disjoint star world, i.e., all obstacles are strictly starshaped and mutually disjoint. However, in real-life scenario

Background Neighborhood deprivation has been found associated with both type 2 diabetes and lung cancer. The aim of this study was to examine the potential association between neighborhood deprivation and lung cancer incidence or mortality in individuals diagnosed with type 2 diabetes. The results may identify a new risk or prognostic factor for lung cancer in this important subgroup and help deve

This article studies the rise of market research and opinion surveys in Sweden from the 1930s and onward. By focusing on the promotion of empirical knowledge by actors between the academic and the commercial world, such as the economist Gerhard Törnqvist, the article shows how new practices of classifying consumers into social classes were established among marketers and advertisers. These approac

Why was the group seen as a new and promising political and scientific category in the Swedish interwar period, and why was the category redefined in the postwar era? This article sets out to answer these questions through a study of Torgny T. Segerstedt and his analysis of the group category. Lorraine Dastons notion that in scientific practice the epistemology effects the ontology of the studied

This article discusses changing word- and concept-usages after the political radicalisation of the 1960s in Sweden. Following the concept of låginkomsttagare, low-income earner, in mainly newspapers, I show how different meanings were attributed to it by different users in the political spectrum. The theory and method used was inspired by historians like Reinhart Koselleck and Dror Wahrman in thei

During the 20th century, a number of actors and institutions set out to develop taxonomies of the Swedish population. This thesis examines the most im­portant social classification system, the social group, which despite its great importance in administrative, scientific, commercial, political and media con­texts has received little attention in historical research. Invented by the Central Bureau

We understand research for societal engagement as research that is societally relevant in the sense that it fosters engagement and collaboration among different social actors. If you are interested in research collaboration with multiple stakeholders from inside and outside the university, this guide will provide you with guidelines to initiate, consolidate, and finalize collaborations, while addr

Background: Neuroinflammation may be associated with global vascular dysfunction and damage. APOE-ε4, a major genetic risk factor for late onset AD, is expressed in neuroinflammatory cells and may lead to increased pro-inflammatory cytokine and nitric oxide production in response to injury. We examined the relationship of vascular dysfunction and damage with a magnetic resonance spectroscopy (MRS)