Type 2 diabetes (T2D) is a complex, metabolic disorder characterized by hyperglycaemia because of defects in insulin secretion and sensitivity. The rapid increase in T2D is likely to reflect the influence of both genetic and environmental factors in disease development. However, the genetic aetiology of T2D remains largely unknown. Thus, the aim of this thesis was to study the role of genetic vari

Essä om apokalyptiska motiv i The Road Warrior (Mad Max II, 1981) och allmänt i populärfilmen 1970-2000.

Isotropic and anisotropic ESR spectra were observed for the radical anions of hexafluorocyclobutene (c-C4F6-), octafluorocyclopentene (c-C5F8-) and perfluoro-2-butene (CF3CFCFCF3-) in γ-irradiated plastically crystalline neopentane, tetramethylsilane (TMS) and TMS-d12 matrices, or the rigid 2-methyltetrahydrofuran (MTHF) matrix. The isotropic spectra of c-C4F6- and c-C5F8- are characterized by thr

The variation of the drag (CD) and lift coefficients (CL) of two fixed solid spherical particles placed at different positions relative each other is studied. Simulations are carried out for particle Reynolds numbers of 50, 100 and 200 and the particle position is defined by the angle between the line connecting the centers of the particles and the free-stream direction (a) and the separation dist

The MUI project looks at flexible ways of creating user-initiated connections between services in wireless networks. A central idea is to migrate user interfaces from controlled devices to devices with better input/output capabilities. The paper shows the different parts of the MUI architecture, and motivates design choices. An initial implementation and a framework for building MUI services are d

The objective of this study was to investigate the epidemiology, etiology, and long-term outcome of an extended outbreak of acute hepatitis that occurred in an area of Sweden between 1969 and 1972. The outbreak was analyzed retrospectively by retesting stored frozen serum samples for the presence of hepatitis A, B and C markers. The results were compared with the diagnoses that had been determined

The Oxford-12 Item Knee Score is a recently developed and validated patient-completed outcome measure designed specifically for use with knee arthroplasty in the United Kingdom. We have translated this questionnaire into Swedish and tested the validity and reliability of the translated version in a cross-sectional study by a postal survey to 1,200 randomly selected patients from the Swedish Knee A

The deposition process in a homogeneous electric field, and the subsequent microscopic arrangement of charged, metallic nanoparticles in the size range below 100 nm on flat substrate surfaces is described. The main aspect of the investigation is the transfer of the particles from a three-dimensional distribution in the gas phase into their arrangement on the substrate surface, in dependence on par

Vanadate and peroxovanadate (pV), potent inhibitors of tyrosine phosphatases, mimic several of the metabolic actions of insulin. Here we compare the mechanisms for the anti-lipolytic action of insulin, vanadate and pV in rat adipocytes. Vanadate (5 mM) and pV (0.01 mM) inhibited lipolysis induced by 0.01-1 microM isoprenaline, vanadate being more and pV less efficient than insulin (1 nM). A loss o

Popular Abstract in Swedish Sammanfattning I debatter och forskning om narkotikapolitik anges den svenska och nederländska modellen ofta som ett motsatspar. Såväl målet för, som utformningen av, narkotikapolitiken har framställts som radikalt olika. Detta synsätt kan sägas vara riktigt. Målet för den svenska narkotikapolitiken är att skapa ett narkotikafritt samhälle. Den nederländska strävar efteIn debates about the Swedish and Dutch drug policies are usually positioned as opposites. The goal for the Swedish drug policy is to create a 'drug-free society'; while in the Netherlands a harm reduction approach prevails. In this study a drug policy is considered a practice of formal social control that can develop differently depending on the contexts in which it emerged. The period studied sta

In this paper, we propose an adaptive observer for dynamically positioned ships, that can be used together with the controller shown by Fossen and Grovlen, to design an observer-based adaptive control scheme. The resulting closed-loop system is globally asymptotically stable with respect to the ship positions and velocities, and globally stable with respect to adaptation to unknown parameters. A d

Popular Abstract in Swedish Avhandlingen är en ny edition med en parallell engelsk översättning av åtta grekiska berättelser relaterade till ökenfadern Daniel från Sketis: 1) Abba Daniel från Sketis; 2) Abba Marcus, den helige dåren; 3) Den blinde mannen; 4AB) En helig och kysk ung kvinna; 5) Kvinnan som låtsades vara en drinkerska; 6) Eulogios Stenhuggaren; 7) Andronikos Penningväxlaren och hans This volume is a new edition with a parallel English translation of eight Greek stories related to Daniel of Sketis: 1) Abba Daniel from Sketis; 2) Abba Mark the Fool; 3) The blind man; 4AB) A holy and chaste young woman; 5) The woman who pretended to be a drunkard; 6) Eulogios the Stone-cutter; 7) Andronikos the Money-dealer and his wife Athanasia; 8) Anastasia Patrikia. The stories deal with se

Using simple sequence-based potentials, the folding properties of a designed three-helix-bundle protein, an alpha-helix and a beta-hairpin are studied. The three-helix-bundle protein is modelled using 5-6 atoms per amino acid and is found to undergo a first-order-like folding transition in which chain collapse and helix formation cannot be separated, which is in-accord with experimental data. The

The interventions of portable digital devices such as mobile telephones, mp3 players, PDAs and many others, have contributed to the formation of contemporary notions of space. The impact of these devices' mobility (informing the users' mobility) could even be paralleled to the shift from the effects of still photography to those of film in the 19th century. Especially important for the perspective

Recent experiments indicate that the external perturbations, related e.g. to high-amplitude shear oscillations of the surface of a quartz crystal microbalance sensor, may suppress binding of mesoscopic aggregates (e.g., polystyrene spheres, vesicles, large proteins, etc.) to the surface. Using a simple kinetic model, we derive equations making it possible to conceptually understand and to mathemat