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Radiation-induced platelet-endothelial cell interactions are mediated by P-selectin and P-selectin glycoprotein ligand-1 in the colonic microcirculation.

BACKGROUND: Antiplatelet reagents have been reported to protect against intestinal damage associated with abdominal radiotherapy, but the mechanisms behind radiation-induced platelet-endothelium interactions are not known. We sought to define the adhesive mechanisms that regulate radiotherapy-induced platelet-endothelial cell interactions in the colon. METHODS: All mice except the controls were ex

Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.

BACKGROUND: The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of

Transitivity in discourse : A comparison of Greek, Polish and Swedish

Popular Abstract in Swedish Olika morfologiska former i olika språk antas bero på gemensamma kognitiva funktioner och semantiska egenskaper. En övergripande term för sådana semantiska egenskaper är transitivitet. Transitivitet yttrar sig bl.a. i aspekt hos verbet och bestämdhet hos objektet. En avgörande kognitiv funktion är för- och bakgrundsstruktur av information. Detta testas här empiriskt i (This work assumes that various linguistic forms in different languages are related to common cognitive functions and semantic properties. A cognitive function - presumably universal - is information transmission. The notion of interest is transitivity, which contains a set of semantic properties such as agentivity, dynamism, affectedness, boundedness and givenness, and the explicit forms are verb

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

FYN is a non-receptor tyrosine kinase belonging to the SRC family of kinases, which are frequently over-expressed in human cancers, and play key roles in cancer biology. SRC has long been recognized as an important oncogene, but little attention has been given to its other family members. In this report, we have studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia (AML).

Dispersion relations for extinction of acoustic and electromagnetic waves

This thesis deals with physical limitations on scattering and absorption of acoustic and electromagnetic waves. A general dispersion relation for the extinction cross section of such waves is derived from the holomorphic properties of the scattering amplitude in the forward direction. The result states that for a given volume, there is only a limited amount of scattering and absorption available i

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.

To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P