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Late-onset sepsis treatment in very preterm infants alters longitudinal microbiome trajectory with lower abundance of Bifidobacterium despite probiotic supplementation
Introduction: Taxonomic instability within the dynamic gut microbiome of very preterm infants can be associated with various adverse outcomes. This longitudinal study was designed to follow the trajectory of microbiome composition and abundance in a cohort of probiotic supplemented very preterm infants with and without sepsis. Methods: Stool samples (n = 180) from probiotic-supplemented participan
Vacuum impregnation for β-carotene retention in mango prior to solar drying
Vacuum impregnation (Ⅵ) is a versatile processing technique that enhances the nutritional and functional properties of fruits and vegetables by infusing bioactive compounds into their porous structures. This study demonstrates the utility of Ⅵ for fortifying fresh mango with β-carotene, a critical nutrient for addressing vitamin A deficiency, and for mitigating nutrient loss during solar drying. F
NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy
Human dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in pyrimidine de novo synthesis and represents a promising target for cancer therapy. However, current inhibitors of DHODH have limited clinical effectiveness and adverse effects. Herein, we report NK-A 17E-233I, a novel small-molecule inhibitor of the human DHODH enzyme, identified through a prospective virtual screening metho
Fate and transport of perfluoroalkyl acids (PFAAs) in soil and groundwater
PFAAs emission to the environment represents a potential risk to human health. Although, long-term global scale fate and transport models have been used to investigate potential trends in environmental levels, temporal trends and transports mechanisms of PFAAs are not fully understood. Due to high solubility in water, the behaviour of PFAAs in soil is important for environmental fate estimation an
Effects of various organic compounds on growth and phosphorus uptake of an arbuscular mycorrhizal fungus
The influence of three organic compounds and bakers' dry yeast on growth of external mycelium and phosphorus uptake of the arbuscular mycorrhizal fungus Glomus intraradices Schenck and Smith (BEG 87) was examined. Two experiments were carried out in compartmentalized growth systems with root-free sand or soil compartments. The sand and soil in the root-free compartments were left untreated or unif
A global database of soil microbial phospholipid fatty acids and enzyme activities
Soil microbes drive ecosystem function and play a critical role in how ecosystems respond to global change. Research surrounding soil microbial communities has rapidly increased in recent decades, and substantial data relating to phospholipid fatty acids (PLFAs) and potential enzyme activity have been collected and analysed. However, studies have mostly been restricted to local and regional scales
Opposing effects of nitrogen versus phosphorus additions on mycorrhizal fungal abundance along an elevational gradient in tropical montane forests
Studies in temperate systems provide evidence that the abundance of arbuscular mycorrhizal fungal (AMF) depends on soil nutrient availability, which is mainly explained in the context of resource stoichiometry and differential plant biomass allocation. We applied this concept to an understudied ecosystem - tropical montane forest - analyzing root and AMF abundance along an elevational gradient wit
Slash-and-burn practices decrease arbuscular mycorrhizal fungi abundance in soil and the roots of Didierea madagascariensis in the dry tropical forest of madagascar
Deforestation and the use of fire to clear land have drastic effects on ecosystem functioning and compromise essential ecosystem services, especially in low-income tropical countries such as Madagascar. We evaluated the effects of local slash-and-burn practices on soil nutrients and arbuscular mycorrhizal (AM) fungi abundance in a southwestern Madagascar forest. Nine sampling plot pairs were estab
Fine-tuning Myoelectric Control through Reinforcement Learning in a Game Environment
Objective: Enhancing the reliability of myoelectric controllers that decode motor intent is a pressing challenge in the field of bionic prosthetics. State-of-the-art research has mostly focused on Supervised Learning (SL) techniques to tackle this problem. However, obtaining high-quality labeled data that accurately represents muscle activity during daily usage remains difficult. We investigate th
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This paper presents a decentralized strategy for a team of N robotic manipulators cooperatively grasping and manipulating an object. A two-step strategy has been designed. In the first step, each robot runs N − 1 consensus-based estimators to estimates the wrenches applied to the object by its teammates even when direct all-to-all communication is unavailable. In the second step, each manipulator
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This paper addresses the time-optimal path-tracking problem for redundant manipulators. By integrating path-velocity control into existing task-space robot controllers, the task-space motion can be dynamically scaled to satisfy the torque constraint under both kinematic and dynamic uncertainties. Numerical simulations and experiments demonstrate that trajectory feasibility and path-tracking accura
Infrastructuring independent cultural production : Empirical and conceptual explorations
Denna avhandling undersöker oberoende kulturproduktion som idé(al) och fenomen, särskilt den centrala roll som samarbeten och ömsesidiga beroenden har för oberoende kulturaktörer. Samtida oberoende kulturproduktion både tillåter och kräver organisering i ett spänningsfält av olika förväntningar och begränsade rumsliga, finansiella och mänskliga resurser. I en tid av allt starkare politisk motvind,This thesis engages with the phenomenon of independent cultural production, which empirically shows itself as an idea(l) of self-determined cultural production and collaboration made possible through numerous different relationships. Independence, as a relational concept, achieved through in(ter)dependencies is what this thesis sets out to explore. Definitions of independence in cultural productio
Phosphorus stress-induced root exudates mediated plant-microbe interactions of Melilotus officinalis
Phosphorus deficiency exacerbates the challenges of phytoremediation in mining areas, particularly for herbaceous species. Although Melilotus officinalis L. Pall. (Melilotus) serves as a pioneer species in mine reclamation, its response mechanisms to phosphorus deficiency stress (PDS)—particularly regarding root exudates composition, plant growth, soil properties, and key microbial functional grou
Sustainable Synthesis of Trimethylolpropane, a Biobased Polyol from Renewable Resources by an Integrated Process of Biotechnology and Chemical Reactions
Trimethylolpropane (TMP) is an important industrial chemical used to produce various value-added chemicals and polymers. In this study, both biobased butyraldehyde and formaldehyde were produced by the incomplete oxidation of bio-1-butanol and biomethanol, respectively, and were then used to produce a biobased TMP. High selective incomplete oxidation of primary alcohol to aldehyde is a challenging
Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
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En historia om fyra framstående finsk-amerikanska musiker i början av 1900-talet: Einar Swan, Sylvester Ahola, Wäinö Kauppi och Emil Hurja.A history of four prominent Finnish-American musicians in the early 20th century: Einar Swan, Sylvester Ahola, Wäinö Kauppi and Emil Hurja.
Flexibly unpredictable? : The AI Act as a regulator of a moving target
This chapter has its origins in a Swedish version but has been updated through studies conducted as part of a Nordic research project on the 0governance of AI and automated decision-making in the public sector, and within the framework of a research cluster on the AI welfare state. The analysis aims to deepen our understanding of how European AI regulation is grappling with regulating a moving tar
Multidimensional response mechanism of sulfamethazine migration and antibiotic resistome spread in natural riverbed driven by vertical river water level fluctuations
In order to elucidate the multidimensional response mechanism for migration of antibiotics and spread of resistome in riverbed driven by river water level fluctuations, dynamic reactors were set up to simulate the variation of sulfamethazine vertical migration, biotransformation and resistance genes expression according to fluctuation direction and magnitude. The upward fluctuation of water level
Data‑driven prediction of masonry flexural bond strength : Interpretability and implications
Flexural bond strength is a key parameter influencing the structural performance of masonry, yet its accurate prediction remains challenging due to the complex interplay of multiple material and testing variables. This study presents a machine learning (ML) framework for predicting flexural bond strength using a harmonized database comprising 1041 test specimens. Additionally, a review of 67 publi
