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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by β-amyloid (βA) accumulation, neuroinflammation, excessive synaptic pruning, and cognitive decline. Despite extensive research, effective treatments remain elusive. Here, we identify potassium channel-interacting protein 3 (KChIP3) as a key driver of AD pathology using the 5XFAD mouse model. KChIP3 levels were significan

Resource provisioning for applications hosted in the cloud is a difficult task due to inherent performance variability in the infrastructure. Control theory has proven to be an efficient tool to increase the predictability of cloud applications. However, a prerequisite for a successful control design is an adequate model of the involved dynamics. In this paper we focus on modeling of controlled se

We study the problems of computing the Voronoi diagram and a triangulation of a set of n2 points with O(log⁡n)-bit coordinates in the Euclidean plane in a substantially sublinear in n number of rounds in the congested clique model with n nodes. First, we observe that if the points are uniformly at random distributed in a unit square then their Voronoi diagram within the square can be computed in O

Arabinoxylan (AX) with varying arabinose to xylose (A/X) ratios of 0.85, 0.57 and 0.39 was extracted from wheat bran, and the conformations of the AX polysaccharides dispersed in water were investigated using small-angle X-ray scattering. The persistence length (Lp) and the conformation statistics (expressed by the Flory exponent v or the mass fractal) of the AX varied with their A/X ratios. The L

In this study we investigate risk management trade-offs by evaluating how key persons at workplaces with a potential for exposure to hexavalent chromium (Cr(VI)) reason about what is practically possible in terms of exposure reduction. While the included companies (N = 14) represented different types of processes and work-tasks, interviewees all identified that many types of hazards compete for at

This study explores a novel approach to utilizing waste biomass for syngas production, with the potential for carbon sequestration. An integrated biomass conversion process combining pyrolysis, CO2 reforming, and MILD combustion is proposed. In the proposed system, the bio-oil obtained from pyrolysis can be used in a reforming step, converting it into syngas with a suitable H2/CO ratio for chemica

This qualitative study explores the existential dimensions of youths’ lived experiences in residential care through an existential – phenomenological approach. Based on in-depth interviews and participant observations with 16 youths in Swedish residential care, the study investigates how young people navigate existential concerns such as freedom, anxiety, and meaning within an institutional contex

High-sensitive cardiac troponins are essential biomarkers in the diagnostics of myocardial infarction. However, analytical interference such as macrotroponin, where troponin forms stable complexes with endogenous antibodies, can lead to persistently elevated levels without actual myocardial injury. The first case report presents a young woman with recurrent chest pain and prolonged troponin I elev

Background: People seeking refuge and asylum must often endure diverse adversities before,during, and after migration, making them more susceptible to develop psychologicalproblems. The effect of post-migration stressors on responsiveness to psychologicaltreatment is unclear.Objectives: To: (1) evaluate the scope of the literature on the relation between post-migrationstressors (e.g. struggles rel

Sustainable Welfare is a field of research that deals with the significance and potential contribution of social policy in the wider context of a post-growth transformation. The greatest need for research currently consists in how socio-ecological consumption and production corridors can be implemented democratically.

Deficiency in C1 inhibitor (C1INH, SERPING1) is canonically associated with hereditary angioedema (HAE-C1INH) but not thrombosis. To determine the thrombosis risk conferred by loss of C1INH in the general population, we studied genetically-defined C1INH deficiency across 635,823 participants. Functionally deleterious germline coding variation in SERPING1 was rare (~1:10,000), indicating strong gen

Background Childhood vaccination rates fluctuate over time and do not always meet the levels recommended by the WHO. Objective This study aims to provide an overview of measures countries have introduced to increase vaccination rates. Methods We developed a structured data collection template that was completed by country experts from Europe, Israel, the USA, and Canada. Experts were identified us

“Now that it doesn’t come from the phone, where is the money coming from?” asks a member of Wazee Hukumbuka during one of the farmer-cooperative’s community meetings. Silas, a local leader knowledgeable about community currencies answers swiftly. “As Wazee Hukumbuka, you are paying members for their seeds from a sort of cooperative fund. That’s where the money is coming from. It’s just that you ar

Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T

Trelleborg fortresses – the dream architecture of the Viking Age. In 1934, few decades after the idea of the existence of Jomsborg had been critically rejected, a geometric Viking fortress was surprisingly discovered on Zealand, named after the site, a so called Trelleborg fortress. This was followed by the search for more fortresses all over Scandinavia, a search that is still ongoing. Their ramp

This chapter provides an overview of how claims for state redress have been articulated by memory activists and handled by representatives of the Nordic states from the 1990s to the 2020s. The main types of historical injustices under scrutiny in these processes of “politics of regret” are enslavement and overseas colonialism, abuse in care settings, and forced assimilation of the Sámi and nationa

Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM2.5, PM10 and NO2 on maternal and child proteomic profiles and the risk of daily diary-registered com

We present a numerical scheme for the solution of the initial-value problem for the “bad” Boussinesq equation. The accuracy of the scheme is tested by comparison with exact soliton solutions as well as with recently obtained asymptotic formulas for the solution.

Firms require multi-stakeholder ecosystems to successfully create and implement circular business models for electric vehicle (EV) battery second life. However, there is a notable absence of guiding instruments to assist EV battery ecosystem actors in formulating and managing strategies for battery second-life operations. This study's aim is to analyze how circular ecosystems are formed and manage