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Characterizing peptide-mediated DNA internalization in human cancer cells.

Cell penetrating peptides (CPPs) are currently used to deliver various macromolecular cargos to intracellular sites of action both in vitro and in vivo on an experimental basis. During the last few years, even more evidence has accumulated indicating that the main route of entry for most CPPs is through endocytosis rather than direct membrane penetration, as initially proposed. The specific endocy

Mode of Coreceptor Use by R5 HIV Type 1 Correlates with Disease Stage: A Study of Paired Plasma and Cerebrospinal Fluid Isolates.

Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme

Cardiovascular event risk in relation to dietary fat intake in middle-aged individuals: data from The Malmo Diet and Cancer Study

BACKGROUND AND DESIGN: The hypothesis that diets rich in total and saturated fat and poor in unsaturated fats increase the risk for cardiovascular disease is still vividly debated. The aim of this study was to examine whether total fat, saturated fat, or unsaturated fat intakes are independent risk factors for cardiovascular events in a large population-based cohort. METHODS: 28 098 middle-aged in

Combination of FVIII and by-passing agent potentiates in vitro thrombin production in haemophilia A inhibitor plasma.

The by-passing agents, recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrate (APCC), are important tools in the treatment of patients with haemophilia A and high-responding inhibitory antibodies. It has been observed clinically that in some patients undergoing immune tolerance induction the bleeding frequency decreases, hypothetically caused by a transient haemost

Grading the amount of electrochemcial active sites along the main flow direction of an SOFC

A fully coupled computational fluid dynamics (CFD) approach based on the finite element method, in two-dimensions, is developed to describe a solid oxide fuel cell (SOFC). Both hydrogen and carbon monoxide are considered as electrochemical reactants within the anode. The dimensionless number of electrochemical active sites (EAS), the pore radius (indirectly proportional to the particle radius) and

Why Issue Equity Abroad - Corporate Reasons and Stock Market Responses

In a world with imperfectly integrated national capital markets the cost of funds is, in general, different across markets. If individual countries, by mutual agreement, or forced by factors outside their control, embark on a process of deregulation and financial integration, the spread in the cost of funds across markets will narrow. Some types of impediments, such as explicit capital controls, w

Memory-based attentional biases: Anxiety is linked to threat avoidance.

The purpose of the present research was to examine if anxiety is linked to a memory-based attentional bias, in which attention to threat is thought to depend on implicit learning. Memory-based attentional biases were defined and also demonstrated in two experiments. A total of 168 university students were shown a pair of faces that varied in their emotional content (angry, neutral, and happy), wit

Dielectric properties of porous cement mortar: fractal surface effects

We have studied the electrical properties of cement mortars in the frequency range 10-4-107 Hz, for different water contents. The admittance scales as a power law with an exponent of about 0.7 in a wide frequency range. This behaviour is interpreted in terms of polarization and diffusion at fractal pore surfaces. We obtain a fractal dimension of 2.4, which is in good agreement with adsorption isot

Determination of Radiative Lifetimes In the 3d(10)np(2)p Sequence of Neutral Copper By Time-resolved Vuv Laser-spectroscopy

Lifetimes in the 3d(10)np(2)P sequence in neutral copper were measured by time-resolved laser spectroscopy. Excitation from the ground state was performed with pulsed laser radiation in the; vuv spectral region, generated by resonant sum-difference four-wave mixing in krypton gas. The lifetimes were evaluated from recorded optical transients. For the np(2)P(J) states we find the following: tau(n =

The Swedish Early Psoriatic Arthritis Register -- 2-year Followup: A Comparison with Early Rheumatoid Arthritis.

OBJECTIVE :Patients with symptoms and signs compatible with psoriatic arthritis (PsA), with or without psoriasis, have been documented in the Swedish Early Psoriatic Arthritis (SwePsA) register. Our aim was to find markers for disease progression and to evaluate treatments for PsA using these data. METHODS: Patients referred to rheumatology outpatient clinics within 2 years of onset were assessed

Droplet-target laser-plasma source for proximity x-ray lithography

A compact, high-brightness and practically debris-free laser-plasma soft x-ray source for proximity x-ray lithography is described. The target of the source is small liquid fluorocarbon droplets injected into vacuum with a piezoelectrically vibrated nozzle. Emission from helium- and hydrogenlike fluorine in the 1.2-1.7 nm wavelength range was determined to similar to 2X10(12) photons/(sr-pulse). w

Serum transferrin carrying the xeno-tetrasaccharide NeuAc-Gal-GlcNAc2 is a biomarker of ALG1-CDG.

ALG1-CDG (formerly CDG-Ik) is a subtype of congenital disorders of glycosylation (CDG) where the genetic defect disrupts the synthesis of the lipid-linked oligosaccharide precursor required for N-glycosylation. The initial step in the investigation for these disorders involves the demonstration of hypoglycosylated serum transferrin (TF). There are no specific biomarkers of this CDG subtype known t

Lung function, forced expiratory volume in 1 s decline and COPD hospitalisations over 44 years of follow-up.

The use of baseline lung function in the prediction of chronic obstructive pulmonary disease (COPD) hospitalisations, all-cause mortality and lung function decline was assessed in the population-based "Men Born in 1914" cohort.Spirometry was assessed at age 55 years in 689 subjects, of whom 392 had spirometry reassessed at age 68 years. The cohort was divided into three groups using fixed ratio (F

Core-polarization effects and radiative lifetime measurements in PrIII

New radiative lifetimes of eight levels in Pr III have been measured using the time-resolved laser-induced fluorescence method. A tunable frequency-doubled dye laser with 1-ns pulse duration was used to excite selectively doubly ionized praseodymium in a laser-produced plasma. The experimental results agree generally well with theoretical data, provided core-polarization effects are considered in

Are allergenic disperse dyes used for dyeing textiles?

Background: There are no data showing that disperse dyes, used to patch test patients, are currently being used for dyeing synthetic garments. It is unknown whether disperse dyes, which are currently routinely patch tested, are in fact present in synthetic textiles on the market. Objectives: To determine whether eight disperse dyes, hitherto most widely cited as allergenic, are still used in tex

The chimney graft: a technique for preserving or rescuing aortic branch vessels in stent-graft sealing zones.

PURPOSE: To report an alternative to the fenestrated stent-graft for preserving blood flow to side branches in the sealing zones of aortic stent-grafts. TECHNIQUE: A covered stent is deployed parallel to the main aortic stent-graft, protruding somewhat proximally, like a chimney, to preserve flow to a vital side branch covered by the aortic stent-graft. Use of a chimney graft makes it possible to