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Background: Photoallergic contact dermatitis (PACD) is an uncommon condition, and there is a lack of validated criteria for its diagnosis. Objective: To identify a set of relevant criteria to be considered when suspecting a diagnosis of PACD and to assess the reproducibility of these criteria. Methods: This was a diagnostic item selection and reliability study performed between July 2012 and Octob

Background There are limited data comparing radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation. Methods We randomly assigned 294 patients with paroxysmal atrial fibrillation and no history of antiarrhythmic drug use to an initial treatment strategy of either radiofrequency catheter ablation (146 patients) or the

We investigated neural distinctions between inflectional and derivational morphology and their interaction with lexical frequency using the mismatch negativity (MMN), an established neurophysiological index of experience-dependent linguistic memory traces and automatic syntactic processing. We presented our electroencephalography (EEG) study participants with derived and inflected words of variabl

Sterically hindered amines, such as 2-amino-2-methyl-1-propanol (AMP), are an interesting alternative to the amines used in conventional CO2 absorption processes in industrial applications. One reason for this is because the carbamate formed is not stable, which may be beneficial during the regeneration of the amine solution in terms of a reduced energy requirement. This paper presents experiment

We demonstrate that the crystal structure of InAs nanowires call be controlled with nanowire diameter and growth temperature. At small diameters, the nanowires exhibit a wurtzite Structure. As the diameter is increased, there is a crossover to the zinc blende structure. The crossover is less sharp at lower growth temperature and L, the crossover diameter decreases as the growth temperature is incr

BACKGROUND: A novel way to evaluate muscle strength and functioning in the lower limbs is to measure how high a person could step up on a platform, the so called Maximal Step-up Test (MST). Studies of healthy persons and overweight women have shown that the maximal step-up height (MSH) is associated with both muscle strength and physical function, but no study has assessed persons after stroke. OB

Exposure, sensitivity and adaptive capacity are essential, albeit theoretically vague, components of climate vulnerability. This has triggered debate surrounding how these factors can be translated into, and understood in, an empirical context subject to present and future harm. In this article, which draws on extensive fieldwork in the Lake Victoria Basin of Kenya and Tanzania, we illustrate how

Background: It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy. Objective: To evaluate the significance of the impurities found in the commercial dyes Disperse Orange 1 (DO1) and Disperse Yellow 3 (DY3) regarding contact allergy in patients with known sensitivity to them. Metho

Background: Patch testing has been used for more than 100 years as the best means to diagnose contact allergy. The increased use of the technique makes standardization of the methodology most important. Progress in the standardization of the patch test technique has been made through guidelines. Objectives: To investigate the intra-individual and inter-individual differences in reading of patch

Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent meta-analysis concluded that the International Ovarian Tumor Analysis (IOTA) algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. We sought to develop and validate a model to predict the risk of malignancy in ad

NOD2, a cytosolic receptor for the bacterial proteoglycan fragment muramyl dipeptide (MDP), plays an important role in the recognition of intracellular pathogens. Variants in the bacterial sensor domain of NOD2 are genetically associated with an increased risk for the development of Crohn disease, a human chronic inflammatory bowel disease. In the present study, global protein expression changes a

In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylat

Fungi, such as Candida spp., are commonly found on the skin and at mucosal surfaces. Yet, they rarely cause invasive infections in immunocompetent individuals, an observation reflecting the ability of our innate immune system to control potentially invasive microbes found at biological boundaries. Antimicrobial proteins and peptides are becoming increasingly recognized as important effectors of in

The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10 years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants a

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The vacuolar calmodulin (CaM)-stimulated Ca(2+)-ATPase, BCA1p, in cauliflower (Brassica oleracea) has an extended N terminus, which was suggested to contain a CaM-binding domain (S. Malmström, P. Askerlund, M.G. Palmgren [1997] FEBS Lett 400: 324-328). The goal of the present study was to determine the role of the N terminus in regulating BCA1p. Western analysis using three different antisera show