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Management of postmenopausal bleeding in Sweden: a need for increased use of hydrosonography and hysteroscopy.

Background. The objective was to determine how postmenopausal bleeding (PMB) is managed in Sweden today, and to relate the findings to a new evidence-based algorithm for the management of PMB. Methods. A questionnaire regarding the role of ultrasound and the use of different endometrial biopsy methods in the management of PMB was sent to all 61 gynecologic departments in Sweden. Results. Fifty-n

Diagnostic stability in adolescent onset psychotic disorders

The purpose was to examine the long-term stability of a diagnosis of psychotic disorder in adolescence and to focus on diagnostic change over time. A total of 88 patients with a first episode of early onset psychosis (before 19 years) were followed up an average of 10.5 years (range 5.1-18.2) after admission. This report includes the 68 patients who could be traced and interviewed with the Positiv

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. Using artificial neural networks as well as standard hierarchical clustering techniques, the tumors could be classified according to ER status, and a list of

Vertebrate host specificity of wild-caught blackflies revealed by mitochondrial DNA in blood

Blood-feeding blackflies (Diptera: Simuliidae) transmit pathogens, harass vertebrate hosts and may cause lethal injuries in attacked victims, but with traditional methods it has proved difficult to identify their hosts. By matching mitochondrial DNA (mtDNA) sequences in blood collected from engorged blackflies with stored sequences in the GenBank database, relationships between 17 blackfly species

Evolution of a carbohydrate binding module into a protein-specific binder

A carbohydrate binding module, CBM4-2, derived front the xylanase (Xyn 10A) of Rhodothermus marinus has been used as a scaffold for molecular diversification. Its binding specificity has been evolved to recognise a quite different target, a human monoclonal IgG4. In order to understand the basis for this drastic change in specificity we have further investigated the target recognition of the IgG4-

Practical Application of Control Theory to Web Services

This tutorial describes experiences with applying a control theoretical approach to achieving performance guarantees in Web servers, with emphasis on delay control. A model for the server is formulated and translated into a control problem formulation. Limitations of the control theoretic approach are identified that arise due to system non-linearities and modeling inaccuracies. Solutions are prop

Soil microfungi in three Swedish coniferous forests

Microfungi were isolated by the soil washing technique from 5 soil horizons in each of 3 podzolic coniferous forests: Picea abies at Kongalund, S. Sweden, Pinus sylvestris at Ivantjarnsheden and P. abies/P. sylvestris at Nickobacken (both central Sweden). A total of 126 species was identified, of which 45 were found at 3, and 24 at 2 of the sites. Mortierella and Penicillium were the commonest gen

Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment

Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural

Synthesis and characterization of new thioether derivatives of [Os3(CO)12] and [H2Os3(CO)10]; crystal and molecular structures of [Os3(CO)11(L)] [Et2S, Pr2S, S(CH2)5] and [Os3(CO)9(m-H)(m-X){SMe(But)}] (X = H, OH)

Reaction of [Os3(CO)11(NCMe)] with R2S (R = Et, nPr) and MeSBut results in the formation of [Os3(CO)11(L)] (L = thioether) clusters in which the thioethers are coordinated in an equatorial site of the triosmium framework. Such monosubstituted clusters are also formed when [Os3(CO)10(NCMe)2] is reacted with R2S (R = Et, nPr) while reaction of the same cluster with Ph2S or MeSPh results in the forma

Effect of lipase on monoolein-based cubic phase dispersion (cubosomes) and vesicles

The effect of adding a Thermomyces (formerly Humicola) lanuginosa lipase (TLL) to a cubic dispersion of the binary monoolein (MO)-(H2O)-H-2 system and to vesicles formed by the ternary MO-sodium oleate (NaO)(H2O)-H-2 system at high water content has been studied. The change in lipid aggregate structure during the lipolytic process was observed by light microscopy, cryo-TEM, and dynamic light scatt

Landscape regulation of bacterial growth efficiency in boreal freshwaters

Allochthonous organic carbon in aquatic systems is metabolized by heterotrophic bacteria, with significant consequences for the biostructure and energy pathways of freshwater ecosystems. The degree to which allochthonous substrates support growth of bacteria is largely dependent on bacterial growth efficiency (BGE), i.e., bacterial production ( BP) per unit of assimilated carbon. Here we show how

Evolution of paleostress fields and brittle deformation of the Tornquist Zone in Scania (Sweden) during Permo-Mesozoic and Cenozoic times

The NW-SE oriented Sorgenfrei–Tornquist Zone (STZ) has been thoroughly studied during the last 25 years, especially by means of well data and seismic profiles. We present the results of a first brittle tectonic analysis based on about 850 dykes, veins and minor fault-slip data measured in the field in Scania, including paleostress reconstruction. We discuss the relationships between normal and str

Ventilation and window opening in schools, Experiments and Analysis

Popular Abstract in Swedish Syftet har varit att studera tillämpningen av ventilation i skolbyggnader. Huvuddelen av avhandlingen behandlar vädring av klassrum. Analytiska modeller med vilka luftutbytet orsakat av vädring kan beräknas föreslås. Ett mål är att modellerna skall utgöra ett verktyg för projektörer och brukare. Modellerna skall kunna användas när man vill bestämma tidslängden för vädriThe objective of this thesis is to study the application of ventilation in schools buildings. A number of studies of the application of different forms of ventilation are presented. The main part of the thesis focuses on window opening in a classroom. Analytical models for calculation of the air change caused by window airing are proposed. The models are intended to be a tool for designers and occ

Model based robustness analysis of an ion-exchange chromatography step

Process development, optimization and robustness analysis for chromatographic separation are often entirely based on experimental work and generic knowledge. This paper describes a model-based approach that can be used to am process knowledge and assist in the robustness analysis of an ion-exchange chromatography step using a model-based approach. A kinetic dispersive model, where the steric mass

MIMO Channels - Measurements and Analysis

Providing increased transmission speed, quality and an efficient spectrum utilization is crucial for high speed wireless services of today and the future. This thesis is a collection of papers that address an important step in that direction -- the utilization of the spatial domain of the wireless channel. Paper I provides a survey of the most important concepts in channel and radio propagation m