Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting. Stem cell-based therapies for Parkinson'

Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb pair with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard mode

The special issue zooms in on knowledge dynamics that drive innovation processes and new path development in different regional and sectoral contexts. This investigation rests on the differentiated knowledge base approach, which offers a clear distinction between analytical, synthetic and symbolic types of knowledge and deep insights into their idiosyncrasies. The introduction frames knowledge bas

It has been argued that competitive elite sport both a) reduces the humanity of athletes by turning them into beings whose sole value is determined in relation to others, and b) is motivated by a celebration of the genetically superior and humiliation of the weak. This paper argues that while a) is a morally reproachable attitude to competition, it is not what competitive elite sport revolves arou

Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of fli

Advanced combustion concepts like partially premixed combustion (PPC) are sensitive to inlet gas conditions especially inlet temperature. To estimate the combustion parameters like ignition delay on a cycle-to-cycle basis, both complementary filter and extended Kalman filter were designed to estimate the inlet temperature, and the ignition delay was calculated with properly estimated temperature.

Flow patterns for water-butanol, water-toluene and waterhexane two-phase flows were visualized in the cross-shaped junctions of three square glass microchannels with hydraulic diameters of 200 μm, 400 μm and 600 μm. Typical flow pattern maps for water-butanol two-phase flow were developed based on Capillary number of the continuous phase and Weber number of the dispersed phase, and compared with a

The contemporary book business is both globalized and digitalized, whether we are talking international bestsellers or micropublished digital-only e-books. All categories of literature have been profoundly marked by technological and social change. Despite being polar opposites, large-scale media conglomerate publishing and micropublishing are discussed jointly in the article. Globalization and diThe contemporary book business is both globalized and digitalized, whether we are talking international bestsellers or micropublished digital-only e-books. All categories of literature have been profoundly marked by technological and social change. Despite being polar opposites, large-scale media conglomerate publishing and micropublishing are discussed jointly in the article. Globalization and di

The effects of H2 addition on a premixed methane-air flame was studied experimentally with a swirl-stabilized gas turbine model combustor. Experiments with 0%, 25%, and 50% H2 molar fraction in the fuel mixture were conducted under atmospheric pressure. The primary objectives are to study the impacts of H2 addition on flame lean blowout (LBO) limits, flame shapes and anchored locations, flow field

Lactobacillus reuteri metabolises glycerol efficiently to form 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3PDO) by the same mechanism as that for 1,2-propanediol (1,2PDO) conversion to propionic acid and propanol via its propanediol utilization (pdu) pathway. Pdu enzymes are encoded by the pdu-operon, which also contain genes encoding the shell proteins of the microcompartment housing t

Fatigue failure is a distinct possibility in spallation targets like tungsten, subjected to cyclic thermo-mechanical loading caused by beam trips and beam pulses. In this study, the tensile and fatigue properties of pure tungsten from two different processing routes have been determined at room temperature. The specimens tested were sintered, rolled and annealed (RA), as well as sintered and HIPed

PURPOSE: It is well known that blood perfusion is important for the survival of skin flaps. As no study has been conducted to investigate how the blood perfusion in human eyelid skin flaps is affected by the flap length and diathermy, the present study was carried out to investigate these in patients.METHODS: Fifteen upper eyelids were dissected as part of a blepharoplastic procedure, releasing a

In this paper we prove that the recently introduced method of signal apparition optimally separates signals from interfering sources recorded during simultaneous source seismic data acquisition. By utilizing a periodic sequence of source signatures along one source line, that wavefield becomes separately partially visible in the spectral domain where it can be isolated from interfering signals, pr

Large eyelid full-thickness defects are traditionally repaired using flaps with a blood-supplying pedicle, for the reconstruction of the anterior or posterior lamella or both. This is a 2-stage procedure involving occlusion of vision in the affected eye for 4-8 weeks, as the flap pedicle is not divided until vascularization is deemed adequate. However, the importance of using a flap with a pedicle

The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization. Since the advent of the intravenous bisphosphonates, things began to look a bit brighter for patients with bone metastases-b

In the present work, liquid-liquid flow patterns positioned 40 mm downstream the inlet of microchannels were experimentally investigated, including the effect of hydraulic diameter (Dh), liquid properties, aspect ratio of cross section (a) and inlet configuration. Deionized water, butanol, toluene and hexane were selected as probe fluids with water as the continuous phase. Cross-inlet microchannel

Aims and objectives: To explore the barriers for nutritional care as perceived by nursing staff at an acute orthopaedic ward, aiming to implement evidence-based nutritional care. Background: Previous studies indicate that nurses recognise nutritional care as important, but interventions are often lacking. These studies show that a range of barriers influence the attempt to optimise nutritional car

In wavefield signal apparition, acquisition with periodic variations in source activation parameters shifts all or part of a signal cone out to, e.g., the Nyquist wavenumber, enabling perfect separation of simultaneous-source (sim-source) data in a diamond-shaped region below a certain temporal frequency. Cyclic convolution in the spatial frequency domain can be exploited to separate data with kno