Identification of targets for apoptosis induction is important to provide novel therapeutic approaches in breast cancer. Our earlier studies showed that down regulation of protein kinase C δ (PKCδ) induces death in breast cancer cells. In this study we set out to identify previously unrecognized apoptosis regulators in breast cancer cells. To identify candidates, global expression analysis with mi

Caloplaca phlogina is shown here to have two kinds of soralia, yellow soralia with anthraquinones versus whitish or white-green soralia lacking pigments. Both kinds are present, growing side by side, in some localities in Scandinavia, but yellow soralia appear to be more common. In contrast, the populations from halophilous shrubs on the Black Sea coast have predominantly white soralia, and they w

In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which methylation changes with time and exposure to specific microenvironments. Using high-resolution 450K arrays, we provide the most comprehensive DNA methylation study of CLL to date, analyzing paired diagnostic/follow-up samples from IGHV-mutate

Wave damping in vegetation in shallow lakes reduces resuspension and thereby improves the light climate and decreases nutrient recycling. In this study, wave transformation in reed (Phragmites australis) was measured in a shallow lake. Theoretical models of wave height decay, based on linear wave theory, and transformation of the probability density function (PDF), using a wave-by-wave approach, w

The tyrosine kinase encoding genes ABL1 and FGFR1 are involved in fusion genes underlying the myeloproliferative neoplasms chronic myeloid leukemia (CML) and the 8p11-myeloproliferative syndrome (EMS). CML and EMS are both myeloproliferative disorders with an initiating, relatively indolent, chronic phase that after some time progresses into acute myeloid or lymphoid leukemia. The mechanisms under

As the most figurative asset of membership in a majority or minority and the most symbolic aspect of national authority, language is a major site of struggle for majority power and minority resistance. For the purposes of this study, which focuses on the question of Kurdish linguistic rights in Turkey, the sites of struggle for majority power and minority resistance are as follows: the documents o

There are numerous asymmetric extensions of the classical Laplace distribution scattered in the literature. In this survey we discuss their origins and inter-relations. In particular, we point out which types of skew Laplace distributions are essentially the same, described in different, albeit equivalent, parametrizations. In a companion paper cite{KP06} we review the properties of classical and

Although the ability to perform activities of daily living (ADL) is frequently used to identify the impact on daily living caused by health problems such as diseases, impaired eyesight or hearing, it is still not well known what makes people feel hindered in daily living with more or less inability to perform ADL. The aim of this study was to investigate feeling hindered by health problems in dail

We report on methods capable of measuring a rms vertical electron beam size of 3 pm with a runs error of less than 10% at a diagnostic beamline at the Swiss Light Source (SLS). This corresponds to a vertical emittance 01 06 pm rad with a 20% rms error. We showed this capability by presenting the theoretical basis for, and the data from, a series of measurements on a stable beam at 1.6 pm rad verti

The galectins are known to be able to recognize and cross-link beta-D-galactopyranoside-containing glycoconjugates as a result of presenting multiple binding sites. This review summarizes efforts in our group for the last ten years towards low-molecular weight chemically modified carbohydrate derivatives. In addition to providing an avenue for improved affinity and galectin-selectivity, we have fo

Emergency and crisis management research is tightly coupled to practical problems. Yet, within that research tradition, surprisingly little has been done in terms of developing a practice of design research. The present report presents literature surveys aimed at investigating how, and to what extent, such research has been conducted. Although the focus is on command and control problems the mater

A combination of the inclusive diffractive cross section measurements made by the H1 and ZEUS Collaborations at HERA is presented. The analysis uses samples of diffractive deep inelastic ep scattering data at a centre-of-mass energy root s = 318 GeV where leading protons are detected by dedicated spectrometers. Correlations of systematic uncertainties are taken into account, resulting in an improv

Purpose – The purpose of this paper is to explore how students construct narratives of themselves as information seekers in a school context where their descriptions of their information activities are assessed and graded. Design/methodology/approach – Blog posts on credibility judgements written by 28 students at a Swedish upper secondary school were analysed through a bottom-up coding process b

N-15 labeled ammonium, glycine or glutamic acid was injected into subarctic heath soil in situ, with the purpose of investigating how the nitrogen added in these pulses was subsequently utilized and cycled in the ecosystem. We analyzed the acquisition of N-15 label in mycorrhizal and non-mycorrhizal plants and in soil microorganisms, in order to reveal probable differences in acquisition patterns

Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. The ensuing osmotic mitochondrial swelling and loss of bioenergetic function is referred to as the mitochondrial permeabili