MYBL2 is a transcription factor, which regulates the expression of genes involved in cancer progression. In this study, we investigated whether putative functional variants in genes regulating MYBL2 (E2F1, E2F3 and E2F4) or in genes, which are regulated by MYBL2 (BCL2, BIRC5, COL1A1, COL1A2, COL5A2, ERBB2, CLU, LIN9 and TOP2A) affect breast cancer (BC) susceptibility and clinical outcome. Twenty-e

The electronic structure of cobalt phthalocyanine (CoPc) changes upon encapsulation inside multi-walled carbon nanotubes (CoPc@MWNT), as detected in this research using Co-K-edge X-ray absorption near-edge structure spectroscopy (XANES) and Co-K alpha(1) resonant inelastic X-ray scattering (RIXS). The CoPc molecules are no longer planar once inside the nanotubes, and the molecular symmetry is foun

Popular Abstract in Swedish Det övergripande syftet med föreliggande studie är tudelat. För det första syftar den till att på teoretisk väg etablera en dialog mellan queerteoretisk och socialpsykologisk teoribildning om aktörer och aktörsskap med utgångspunkt i en kritisk läsning av Judith Butler och George Herbert Mead. För det andra syftar den till att på empirisk väg utveckla och fördjupa dennaIn her widely quoted and criticised Gender Trouble, Judith Butler elaborates the idea that gender needs to be understood as performative – a certain kind of “doing” within the regulative realm of a hegemonic heterosexuality that is assumed to govern intelligible bodily configurations. Drawing mainly on psychoanalytical and Foucaultian arguments, Butler dwells upon questions concerning power and su

The exposure to fragrances is widespread and contact allergy to fragrance substances affects 1–4% of the general population. Many fragrance substances are volatile and it can therefore be suspected that they may evaporate from petrolatum patch test preparations applied in test chambers. In the first two papers included in this thesis the aims were to i) to investigate the stability of fragrance pr

Aims: The aim was to compare the impact of socioeconomic groups (SEG) on the risk of being a daily smoker or quitter, and to investigate whether the potentially mediating effect of psychosocial working conditions was similar in the Danish and the Swedish populations. Methods: The study populations consisted of 10,049 employed participants, aged 18-64 years, 51% women, randomly selected from the ge

Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement recept

The Middle East, home to 6.3 percent of the world’s population and containing only 1.4 percent of the world’s renewable fresh water, is experiencing an increasing water scarcity crisis.1 The UN presented an alarming report during the last World Water Forum in March 2009 painting a bleak picture of increasing demand and diminishing water supplies.2 Scientifically, the Middle East ran out of water i

The Seebeck coefficient, a key parameter describing a material's thermoelectric performance, is generally difficult to measure, and no intrinsic calibration standard exists. Quantum dots and single electron tunneling devices with sharp transmission resonances spaced by many kT have a material-independent Seebeck coefficient that depends only on the electronic charge and the average device temperat

Syftet med detta projekt är att göra uppdaterade och utvecklade livscykelanalyser för biodrivmedel som är aktuella i Sverige idag. Fokus ligger på att göra så transparenta och relevanta jämförelser som möjligt och att lyfta fram de steg i livscykeln som signifikant påverkar respektive biodrivmedels miljöprestanda. I studien görs känslighetsanalyser som visar effekterna av t ex framtida förändrade

Background: To study motor ability at seven years of age in children treated for idiopathic clubfoot and its relation to clubfoot laterality, foot status and the amount of surgery performed. Methods: Twenty children (mean age 7.5 years, SD 3.2 months) from a consecutive birth cohort from our hospital catchments area (300.000 inhabitants from southern Sweden) were assessed with the Movement Assessm

Öppna digitala Iärresurser (Open Educational Resources, OER) är undervisnings-, lärande- och forskningsmaterial som finns tillgängliga på Internet. Resurserna är öppna och fria och vanligen under creative commons licenser (cc). Beroende på licens tillåts resurserna att användas, återanvändas, spridas och även säljas öppet och fritt. Internationellt är OER-rörelsen mycket stark. I Sverige går därem

To assess how synergies between climate warming and increased concentrations of humic substances ("brownification") will affect rotifer community establishment in spring, we conducted a mesocosm experiment where we combined a 3 degrees C temperature increase with a doubling in water color, changes corresponding to modeled projections for the coming 25-75 yr. We also performed a complementary preda

BACKGROUND: Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated wh

In this article, we perform a robust analysis of the determinants of U.S. swap spreads using a wide range of theoretically motivated candidate factors. We conduct an analysis by taking into consideration the interdependence between the candidate factors, as well as the time frequency under which the factors affect the spread. We find that the suggested variables can to a fair degree explain moveme

Understanding the processes generating fluctuations of natural populations lies at the very heart of academic ecology. It is also very important for applications such as fisheries management and pest control. We are interested in the effect of harvesting on population fluctuations and for that purpose we develop and analyze an age-structured model where recruitment is a stochastic process and the

This naturalistic study presents outcomes for three therapy types practiced in psychiatric public health care in Sweden. Data were collected over a 3-year period at 13 outpatient psychiatric care services participating in the online Quality Assurance of Psychotherapy in Sweden (OAPS) system. Of the 1,498 registered patients, 14% never started psychotherapy, 17% dropped out from treatment, and 36%