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Activating mutations of the FLT3 receptors confers poor prognosis while remaining as one of the most common causes for the survival and propagation of these leukemic blast cells. Years of research into second generation inhibitors proved to be initially effective. However, current studies suggest that microenvironment-mediated signals from bone marrow stromal cells are capable of providing cytopro
To achieve a society with sustainable development, the use of valuable non-renewable resources, i.e., the crude oil used for bituminous binder and aggregates must be changed. Meanwhile, the road network is expanding worldwide, requiring more recourses. The asphalt concrete can be recycled up to 100% after being removed from an existing road pavement, which ensures the sustainability of the asphalt
The aspect of sustainability has been a major topic in construction and real estate planning the last decade, but this seems to have fall between the cracks in the fire protection design. Therefor the aim of this thesis is to map building developer and fire engineer’s opinion and understanding about sustainable fire safety. The report also aims to develop an explanation of the concept and investig
During the last decades a brownification of the lakes and streams in the northern hemisphere has been observed. The change has been attributed to an increase of organic content in the water, leached from the top soil layers, called humic substances. Several theories have been proposed to explain the drivers behind the brownification process, among them the decrease of sulfur deposition from reduce
Quantum Cascade Lasers (QCLs) have since their invention in 1994 become a crucial source for mid-infrared and THz radiation. Mid-infrared QCLs have achieved room temperature operation while THz QCLs have not. As such, simulations are an important tool in order to achieve a THz QCL operational at room temperature. This work uses a simulation package based on a nonequilibrium Green’s function model
Enligt lagen (2003:778) om skydd mot olyckor, LSO, har den som äger en byggnad eller bedriver verksamhet i byggnaden det yttersta ansvaret för sitt brandskydd. I skälig omfattning ska det finnas utrustning för livräddning vid brand, och i övrigt ska åtgärder vidtas för att förebygga samt begränsa skador till följd av brand. Det är kommunernas ansvar att utföra tillsyn på brandskyddet så att dettaAccording to Swedish Law (2003:778) on protection against accidents, LSO, the one who owns a building or conducts operations in a building has the ultimate responsibility of their fire protection. To a reasonable extent, there must be equipment for lifesaving in the event of a fire, as well as other measures which must be taken to prevent fire and limit damage as a result of fire. In this study, t
This thesis aims to start from the Branco-Shatz submission aims to analyze the influence of social media in the Legal framework during the migration crisis in Italy through quantitive methods such as data scraping from the comments present in Facebook in public news agencies posts as well as word counting of both the legislation and the comments before mentioned. On top of that, qualitative method
Bakgrund: Ambulanspersonalen ställs inför stora utmaningar när det kommer till att upprätthålla en säker vård i dagens komplexa högriskmiljöer. Genom att arbeta enligt Crew Resource Management och fokusera på icke-tekniska färdigheter är det övergripande målet att undvika vårdskador prehospitalt. Syfte: Syftet med studien var att undersöka specialistsjuksköterskors erfarenheter av att arbeta enl
The family of proteins called galectins, are a group of carbohydrate-binding proteins. This allows them to take part in cell signalling by binding to glycoproteins on cell surfaces. Galectin-9 has been identified as a TIM3 ligand. TIM3 is a protein found on T-cells, which are used by the immune system to destroy for example cancer cells. When galectin-9 binds TIM3 it starts a reaction chain which
Abstrakt Syfte: Syftet med litteraturstudien är att systematiskt sammanställa och beskriva på vilket sätt Crew Resource Management (CRM) används och vilka effekter det ger i akut- och ambulanssjukvårds kontext. Bakgrund: CRM kommer ursprungligen från flygindustrin och har sedan millennieskiftet implementerats i hälso- och sjukvården. Bristande kommunikation är en stor bidragande faktor till att vå
Christiania is a historically and culturally interesting district in the middle of Copenhagen, Denmark. This work is an investigation into the possible ways and methods through which Christiania could be developed in the future. It includes a careful analysis of the factors that have shaped this district, Richard Floridas theory of the creative city, and how to preserve the integrity of this area
Geologi är ett samhällsviktigt ämne som kan kommuniceras genom geoturism. Geoturism är en typ av naturturism med fokus på geologi, som även skapar mervärde åt naturupplevelser och kulturella värden. I en geopark används geoturism som ett verktyg för att förmedla kunskap om jordens historia och det viktiga sambandet mellan geodiversitet och biodiversitet. Geologiska förutsättningar genererar livsviGeology is a socially important subject that can be communicated through geotourism. Geotourism is a type of nature tourism with a focus on geology, which creates added values for the natural and cultural heritage. In a geopark, geotourism is used as a tool to convey knowledge about Earth's history and the important relationship between geodiversity and biodiversity. Geological and geophysical
Introduction: Glioblastoma is the most aggressive form of primary brain tumor in adults. Current treatment including chemotherapy poses a limitation due to consequences of systemic toxicity. Further studies for alternative, multimodal treatments are necessary. Antisecretory factor is an endogenous protein. Studies have shown that it has anti-inflammatory and immune modulatory effects in experiment
Målet med det här examensarbetet var att underlätta för underhållspersonalen på Profilgruppen att byta ut gamla frekvensomriktare som kommunicerar via ControlNet till moderna som kommunicerar via EtherNet/IP. Det har gjorts genom att ta fram en manual som innehåller instruktioner för alla viktiga moment i en systematisk ordning. Dessa instruktioner har skrivits efter att ett par frekvensomriktare The goal of this thesis was to make it easier for the maintenance staff at Profilgruppen to replace old frequency converters that communicate via ControlNet with modern ones that communicate via EtherNet/IP. This has been done by producing a manual that contains instructions for all important steps in a systematic order. These instructions have been written after a few drives were replaced, to be
Giant cell arteritis is a disease the affects the arteries, for example the temporal artery. When affecting the temporal artery, it can cause serious consequences such as blindness and stroke. The existing methods for diagnosing the disease are invasive, time consuming and costly. Ultrasound would therefore be an attractive diagnostic alternative providing a lot of benefits. Information about the
I RH 2014:45 prövade Svea hovrätt för första gången frågan om hur bostadshyresgästers åberopande av rätten till respekt för hemmet enligt artikel 8 EKMR ska hanteras som grund mot uppsägning av ett hyresavtal. Hovrätten konstaterade att en hyresgäst som hyr sin bostad har en mer begränsad rätt till hemmet och föll sedan tillbaka på hyreslagens skälighetsbedömning. Den praxis som etablerades genom In RH 2014:45, the Svea Court of Appeal examined for the first time how residential tenants' invocation of the right to respect for their home according to Article 8 ECHR should be assessed as an argument against the termination of a tenancy agreement. The Svea Court of Appeal stated that a tenant who rents his or her home has a limited right to the home and thereafter based the judgement sole
