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Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. This drug has now attracted new attention since it h
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Background and Purpose - The subventricular zone in the adult brain is identified as an endogenous resource of neuronal precursors that can be recruited to adjacent lesioned areas. The hypothesis was tested that postischemic environmental enrichment might enhance subventricular zone cell genesis. Methods - A cortical infarct was induced in adult spontaneously hypertensive rats by ligating the midd
Background: We have previously demonstrated that patients with Crohn's disease ( CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. Methods: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes
Popular AbstractI denna avhandling analyseras den svenska skogsbruksdebatten under nittonhundratalets tre sista decennier. De ideal och värderingar som genom det moderna skogsbrukets ideologi och praktik kom att råda i skogarna utmanades av miljörörelsen från sextiotalet och framåt. Till en början stod skogsnäringen och miljörörelsen mycket långt från varandra, men under nittiotalet började man näIn this dissertation, the Swedish forestry debate during the last three decades of the 20th century is analysed. The contents, values and underlying assumptions of the debate are investigated from a discoursive point of view. Ideals, methods and aesthetics are analysed, as they have been expressed throughout the debate. Modernity's focus on uniformity, order and culturalisation of nature is contra
Detailed numerical simulations of fires in road tunnels were carried out using the CFD code JASMINE. Fire tests performed in the Ofenegg tunnel have also been validated. A parametric study of fires in an arbitrary 300-m-long tunnel was made, in which the influence of fire size, tunnel width, ventilation and ground slope was investigated. The movement of hazardous temperature and smoke regions as a
Vertebral deformities are a common consequence of osteoporosis and are known to decrease quality of life. The Qualeffo-41 is a quality-of-life questionnaire especially developed for measuring quality of life in patients with vertebral deformities. It consists of 41 questions arranged in five domains: pain, physical function, social function, general health perception, and mental function. The obje
Popular Abstract in Swedish Membranteknik är en separationsteknik där stora partiklar skiljs av från mindre partiklar m.h.a. ett membranfilter. I min forskning har jag tittat på hur membranfiltrering kan användas inom bioteknikindustrin. Jag har tittat på hur mjölksyra kan renas upp från en lösning av jäst "vetemjölsvälling" samt hur första steget i uppreningen av protein A från en industriellt prMembrane filtration is a very gentle separation technique and can be used at low temperatures. This makes it suitable for liquids that contain micro-organisms and/or are heat sensitive, which is often the case in liquids processed in the field of biotechnology. However, one drawback is that these liquids are often very complex, which is a disadvantage when using membrane technology as it makes the
cDNAs encoding two PDE-3 or cyclic GMP-inhibited (cGI) cyclic nucleotide phosphodiesterase (PDE) isoforms, RPDE-3B (RcGIP1) and HPDE-3A (HcGIP2), were cloned from rat (R) adipose tissue and human (H) heart cDNA libraries. Deletion and N- and C-terminal truncation mutants were expressed in Escherichia coli in order to define their catalytic core. Active mutants of both RPDE-3B and HPDE-3A included
A prospective study was conducted to evaluate patient outcomes following trapezial excision and extensor carpi radialis longus tendon arthroplasty in primary trapeziometacarpal arthrosis. Seventeen patients were evaluated both preoperatively and postoperatively at both 12 months and at final follow-up examination at a mean of 39 months (range, 20-56 months). Surgery resulted in complete or signifi
A summary of recent progress in Chiral Perturbation Theory (ChPT) at the two-loop level is given. A short introduction to ChPT is included, along with an explanation of the usefulness of developing ChPT for partially quenched QCD. Further, our recent work in partially quenched ChPT is reviewed, and a few comments are given on older work in mesonic ChPT at the two-loop level. In particular, we quot
Autoignition of a homogeneous mixture is very sensitiveto operating conditions. Therefore fast combustion phasingcontrol is necessary for reliable operation. There areseveral means to control the combustion phasing of a Homogeneous Charge Compression Ignition (HCCI) engine.This paper presents cycle-to-cycle cylinder individual controlresults from a six-cylinder HCCI engine using a VariableValve Ac
The current control design development process in automotive industry and elsewhere involves many expensive experiments and hand-tuning of control parameters. Model based control design is a promising approach to reduce costs and development time. In this process low complexity models are essential. This thesis combines the areas of modeling and model reduction in automotive systems. A model of th
