OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 yea

The social determinants of health form a complex and dynamic web, shaping both populationand individual health and disease. The built environment and especially human dwellingsinfluence health in many ways. Associations between factors such as dampness, mouldgrowth, heating/insulation, and crowding on the one hand and respiratory health andinfectious diseases on the other hand have been studied in

Platsen är London, året är 2036. Miljoner människor dör av infektioner som tidigare kunnat behandlas. Antibiotikan är inte längre verksam mot vanliga infektioner och rädslan sprider sig som ett gift i samhället. Demokratin hotas, politiker mördas och terrordåd drabbar staden. Populister spelar på folkets känslor med slagord som ”Making Britain strong again” och förnekar vetenskapliga upptäckter so

Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was su

Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited. Only a few studies have investigated DNA methylation of selected candidate genes or a very small fraction of genomic CpG sites in human pancreatic islets, the tissue of primary pathogenic importance for diabetes. Our aim was to characterize the whole-genome DNA methylation landscape in human pancreatic islets

The book deals with the issue of independence and especially the way to the Creation of an independent state in the Kurdish region in Iraq. One of the main topics dealt with in the book is the challenges nationally, regionally and internationally to an independent Kurdish state created in the future. We argue that the way to independence is going through negotiations with Baghdad.

The energy justice framework serves as an important decision-making tool in order to understand how different principles of justice can inform energy systems and policies. The realization of the urgency of providing modern energy technology and services particularly to rural areas has prompted both the Nepalese government and development institutions to focus on community-run renewable energy faci

This article highlights the role recycling played in clothes culture as found in examples from Lady Märta Helena Reenstierna’s diary (1793–1839) and garments in Swedish museum collections. By using approaches from Textile Studies, clothes are seen in a lifecycle perspective rather than regarding fashion as luxury consumption focusing on the moment of purchase. Recycling as a concept allows central

Purpose — We wanted to examine the potential of the Scandinavian Sarcoma Group (SSG) Central Register, and evaluate referral and treatment practice for soft-tissue sarcomas in the extremities and trunk wall (STS) in the Nordic countries. Background — Based on incidence rates from the literature, 8,150 (7,000–9,300) cases of STS of the extremity and trunk wall should have been diagnosed in Norway,

Objective: To assess the quality of antibiotic prescribing in primary care in Belgium, the Netherlands and Sweden using European disease-specific antibiotic prescribing quality indicators (APQI) and taking into account the threshold to consult and national guidelines. Design: A retrospective observational database study. Setting: Routine primary health care registration networks in Belgium, the Ne

Objectives: Recent evidence from the 7-year followup of the Pediatric Osteoporosis Prevention (POP) study indicates an inverse correlation between years of participation in a physical activity (PA) intervention and fracture risk in children. However, we could not see a statistically significant reduction in fracture risk, which urged for an extension of the intervention. Setting: The study was con

Sustainability Science is an emerging, transdisciplinary academic field that aims to help build a sustainable global society by drawing on and integrating research from the humanities and the social, natural, medical and engineering sciences. Academic knowledge is combined with that from relevant actors from outside academia, such as policy-makers, businesses, social organizations and citizens. Th