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GamReg Sweden—Protocol for a systematic cohort data collection for improved clinical knowledge in specialized gambling disorder treatment

Background: Gambling disorder is the first non-substance-related addiction which is recognized as a diagnostic entity and assessed in treatment settings. However, in many clinical settings, assessment, and structured treatment for this condition is severely under-developed, and treatment seeking in many settings is low. This is a protocol paper describing the rationale and structure of a recently

Spontaneous Cell Cluster Formation in Human iPSC-Derived Neuronal Spheroid Networks Influences Network Activity

Three-dimensional neuronal culture systems such as spheroids, organoids, and assembloids constitute a branch of neuronal tissue engineering that has improved our ability to model the human brain in the laboratory. However, the more elaborate the brain model, the more difficult it becomes to study functional properties such as electrical activity at the neuronal level, similar to the challenges of

Density matrix renormalization group description of the island of inversion isotopes F 28-33

Background: Recent experiments have confirmed that the neutron-rich isotopes F28,29 belong to the so-called island of inversion (IOI), a region of the nuclear chart around Z=10 and N=20 where nuclear structure deviates from the standard shell model predictions due to deformation and continuum effects. However, while the general principles leading to the IOI are relatively well understood, the deta

Trade-Offs for Climate-Smart Forestry in Europe Under Uncertain Future Climate

Forests mitigate climate change by storing carbon and reducing emissions via substitution effects of wood products. Additionally, they provide many other important ecosystem services (ESs), but are vulnerable to climate change; therefore, adaptation is necessary. Climate-smart forestry combines mitigation with adaptation, whilst facilitating the provision of many ESs. This is particularly challeng

Human-directed attachment behavior in wolves suggests standing ancestral variation for human–dog attachment bonds

Domesticated animals are generally assumed to display increased sociability toward humans compared to their wild ancestors. Dogs (Canis familiaris) have a remarkable ability to form social relationships with humans, including lasting attachment, a bond based on emotional dependency. Since it has been specifically suggested that the ability to form attachment with humans evolved post-domestication

Peatland Heterogeneity Impacts on Regional Carbon Flux and Its Radiative Effect Within a Boreal Landscape

Peatlands, with high spatial variability in ecotypes and microforms, constitute a significant part of the boreal landscape and play an important role in the global carbon (C) cycle. However, the effects of this peatland heterogeneity within the boreal landscape are rarely quantified. Here, we use field-based measurements, high-resolution land cover classification, and biogeochemical and atmospheri

Multi-Stage Phase-Segregation of Mixed Halide Perovskites under Illumination : A Quantitative Comparison of Experimental Observations and Thermodynamic Models

Photo- and charge-carrier-induced ion migration is a major challenge when utilizing metal halide perovskite semiconductors for optoelectronic applications. For mixed iodide/bromide perovskites, the compositional instability due to light- or electrical bias induced phase-segregation restricts the exploitation of the entire bandgap range. Previous experimental and theoretical work suggests that exci

Production of forward heavy-flavor dijets at the LHCb within the kT -factorization approach

We calculate differential cross sections for cc¯- and bb¯-dijet production in pp scattering at s=13 TeV in the kT-factorization and hybrid approaches with different unintegrated parton distribution functions (uPDFs). We present distributions in the transverse momentum and pseudorapidity of the leading jet, the rapidity difference between the jets and the dijet invariant mass. Our results are compa

ProTstab2 for Prediction of Protein Thermal Stabilities

The stability of proteins is an essential property that has several biological implications. Knowledge about protein stability is important in many ways, ranging from protein purification and structure determination to stability in cells and biotechnological applications. Experimental determination of thermal stabilities has been tedious and available data have been limited. The introduction of li

High contrast, isotropic, and uniform 3D-imaging of centimeter-scale scattering samples using structured illumination light-sheet microscopy with axial sweeping

Light-sheet fluorescent microscopy (LSFM) has, in recent years, allowed for rapid 3D-imaging of cleared biomedical samples at larger and larger scale. However, even in cleared samples, multiple light scattering often degrades the imaging contrast and widens the optical sectioning. Accumulation of scattering intensifies these negative effects as light propagates inside the tissue, which accentuates

Positive feedback mechanism between biogenic volatile organic compounds and the methane lifetime in future climates

A multitude of biogeochemical feedback mechanisms govern the climate sensitivity of Earth in response to radiation balance perturbations. One feedback mechanism, which remained missing from most current Earth System Models applied to predict future climate change in IPCC AR6, is the impact of higher temperatures on the emissions of biogenic volatile organic compounds (BVOCs), and their subsequent

Starting a Swedish national quality registry for orthognathic surgery : a tool for auditing fundamentals of care

BACKGROUND: National quality registries (NQRs) provide open data for user-directed acquisition. National Quality Registry (NQR) data are often used to analyze the rates of treatment success and adverse events for studies that aim to improve treatment quality and patient satisfaction. Thus, NQRs promote the goal of achieving evidence-based therapies. However, the scientific literature seldom focuse

Identification and Current Palaeobiological Understanding of “Keratosa”-Type Nonspicular Demosponge Fossils in Carbonates : With a New Example from the Lowermost Triassic, Armenia

Structures similar to fossilized nonspicular demosponges have been reported in carbonates throughout the Phanerozoic and recently in rocks dating back to 890 Ma ago. Interpretation of these records is increasingly influential to our understanding of metazoans in multiple aspects, including their early evolution, the ecology in fossil reefs, and recovery after mass extinction events. Here, we propo

Relativistic Two-Photon Matrix Elements for Attosecond Delays

The theory of one-photon ionization and two-photon above-threshold ionization is formulated for applications to heavy atoms in attosecond science by using Dirac–Fock formalism. A direct comparison of Wigner–Smith–Eisenbud delays for photoionization is made with delays from the Reconstruction of Attosecond Beating By Interference of Two-photon Transitions (RABBIT) method. Photoionization by an atto

Research race-specific reference values and lung function impairment, breathlessness and prognosis : Analysis of NHANES 2007–2012

Background: Spirometry reference values differ by race/ethnicity, which is controversial. We evaluated the effect of race-specific references on prevalence of lung function impairment and its relation to breathlessness and mortality in the US population. Methods: Population-based analysis of the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Race/ethnicity was analyzed as bla

Electrostimulation for promoted microbial community and enhanced biodegradation of refractory azo dyes

Excess azo dyes are detrimental to natural water systems and human health. To effectively treat dye wastewater, two-dimensional cylindrical electrodes were introduced into traditional biofilm reactor (BR), and thus a novel two-dimensional biofilm electrode reactor (2D-BER) was developed. In the 2D-BER, at low current density from 0.53 ± 0.05 mA m-2 to 12.61 ± 1.24 mA m-2, the electrostimulation in

Toward Autonomous Production of mRNA-Therapeutics in the Light of Advanced Process Control and Traditional Control Strategies for Chromatography

mRNA-based therapeutics are predicted to have a bright future. Recently, a B2C study was published highlighting the critical bottlenecks of mRNA manufacturing. The study focused on supply bottlenecks of various chemicals as well as shortages of skilled personnel. The assessment of existing messenger ribonucleic acid (mRNA) vaccine processing shows the need for continuous manufacturing processes th

Assessing Climate Adaptation and Flood Security Using a Benchmark System : Some Swedish Water Utilities as Good Learning Examples

The 2020 Sustainability Index (SI), a benchmark system, shows that 2% of the 184 municipal water and wastewater utilities (WWS) in Sweden have a good performance level (green), i.e., they meet all benchmark requirements for the “climate adaptation and flood safety” (“CA and FS”). In this study, ten Swedish WWS organizations were selected and studied in depth. The goal was to present them as good l

Fluid Management, Intra-Abdominal Hypertension and the Abdominal Compartment Syndrome : A Narrative Review

Background: General pathophysiological mechanisms regarding associations between fluid administration and intra-abdominal hypertension (IAH) are evident, but specific effects of type, amount, and timing of fluids are less clear. Objectives: This review aims to summarize current knowledge on associations between fluid administration and intra-abdominal pressure (IAP) and fluid management in patient