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Symptom relief during last week of life in neurological diseases

Objectives: The aim of this study was to investigate symptom prevalence, symptom relief, and palliative care indicators during the last week of life, comparing them for patients with motor neuron disease (MND), central nervous system tumors (CNS tumor), and other neurological diseases (OND). Material & Methods: Data were obtained from the Swedish Register for Palliative Care, which documents c

Adaptive synchronization of complex networks with general distributed update laws for coupling weights

This paper discusses adaptive synchronization control for complex networks interacted in an undirected weighted graph, and aims to provide a novel and general approach for the design of distributed update laws for adaptively adjusting coupling weights. The proposed updating laws are very general in the sense that they encompass most weight update laws reported in the literature as special cases, a

Circulating lipids, mammographic density, and risk of breast cancer in the Nurses’ Health Study and Nurses’ Health Study II

Purpose: Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulating lipid levels influence mammographic density and breast cancer risk. Therefore, we examined these associations in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII),

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Background & Aims: Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases. Methods: First, we performed a genome-wide association study (GWAS) in 8,289 individuals from UK Biobank, whose liver iron level had been

One-year postpartum anthropometric outcomes in mothers and children in the LIFE-Moms lifestyle intervention clinical trials

Background/objectives: Excess gestational weight gain (GWG) is a risk factor for maternal postpartum weight retention and excessive neonatal adiposity, especially in women with overweight or obesity. Whether lifestyle interventions to reduce excess GWG also reduce 12-month maternal postpartum weight retention and infant weight-for-length z score is unknown. Randomized controlled trials from the LI

Autoantibodies in Pandemrix®-induced narcolepsy : Nine candidate autoantigens fail the conformational autoantibody test

Study objectives: Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with Pandemrix®. Genetic association to HLA DQB1*06:02 implies an autoimmune origin, but target autoantigen remains unknown. Candidate autoantigens for NT1 have previously been identified in solid-phas

Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study

Background: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additio

Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment : the effect of age at onset

Objective: The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods: We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at

Karbapenemresistenta Escherichia coli finns nu i Sverige

Escherichia coli som producerar ESBLCARBA, vilket bryter ner karbapenemer, har blivit allt vanligare utomlands. Stammar som producerar NDM-1 uppfattas som ett stort hot, eftersom de är multiresistenta och ökar snabbt globalt. De fall av NDM-1 som tidigare påvisats i Sverige har isolerats från patienter som blivit koloniserade i samband med resa eller vård utomlands. Vi presenterar här det första k

Quantitative Evaluation of Temporal Episode Patterns in Paroxysmal Atrial Fibrillation

Flow velocity in left atrial appendage decreases when paroxysmal atrial fibrillation (PAF) progresses to longer episodes, suggesting that the temporal PAF episode pattern may be related to risk of thrombus formation. This study investigates the feasibility of discriminating episode patterns based on two descriptors: the aggregation characterizes the temporal distribution of PAF episodes, whereas t

Memory for Problem Solving: Comparative Studies in Attention, Working and Long-term Memory

Living in a complex and dynamically changing environment requires accurate and timely behavioural responses that allow for adapting to such changes. Well-developed perceptual systems provide a continuous flow of abundant and up-to-date information on the changes in the environment, and, thereby, allow for tailoring behavioural responses accordingly. However, issuing any behavioral response would n

Substance P and vasoactive intestinal peptide in bullous and inflammatory skin disease.

Immunoreactivity (IR) of substance P (SP) and Vasoactive Intestinal Peptide (VIP) were determined by radioimmunoassay in serum of 56 patients with inflammatory skin diseases, in blister fluid of 40 patients with spontaneous blisters and 31 subjects with induced skin blisters. Serum concentrations of SP-IR and VIP-IR were mostly low or non-detectable. Spontaneous blisters contained high amounts of

The effect of capsaicin on some experimental inflammations in human skin.

Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals. In experiments on human skin inflammation was induced by injection of substance P (SP) or histamine intradermally, UV irradiation, non-immunologic contact urticaria, tuberculin reaction, contact allergens and benzalkonium chloride with or without capsaicin pretreatment. The flare response to SP a

Occurrence of substance P, vasoactive intestinal peptide and calcitonin gene-related peptide in dermographism and cold urticaria.

Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides,

The politics of persuasion. : Opinion-shaping activities and gender equality in Sweden, 1960-1970

In this paper, the role and significance of opinion-shaping and persuasion activities are explored through an analysis of the activation of women in the Swedish labour market in the 1960s, highlighting the ways in which gender equality ideals became infused in these activities through a process of ‘transformative state feminism’. The analysis draws on qualitative data including archival material aIn this paper, the role and significance of opinion-shaping and persuasion activities are explored through an analysis of the activation of women in the Swedish labour market in the 1960s, highlighting the ways in which gender equality ideals became infused in these activities through a process of ‘transformative state feminism’. The analysis draws on qualitative data including archival material a

Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory mediated responses.

The effects evoked by intradermal injections of substance P (SP), neurokinin A (NKA) or calcitonin gene-related peptide (CGRP) were studied in 51 non-atopic subjects. SP and NKA produced flare and weal, and CGRP produced an indurated erythema. The reactions to SP were strong, the flare being maximal 3–5 min after injection and the weal after 10–15 min. NKA evoked a much weaker flare and a slightly