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Use of atorvastatin as an anti-inflammatory treatment in Crohn's disease.

Background and purpose:Experimental and clinical investigations have revealed that statins can downregulate both acute and chronic inflammatory processes. Whether statins express anti-inflammatory activities in the treatment of Crohn's disease is unknown.Experimental approach:Ten patients were given 80 mg atorvastatin once daily for 13 weeks and then followed up for 8 weeks after the treatment. Th

Mental disorders in suicide and undetermined death in the Lundby Study. The contribution of severe depression and alcohol dependence.

To evaluate the role of severe depression, i.e., depression with melancholic and/or psychotic features and alcohol dependence in suicide and undetermined death. The Lundby Study is a prospective, longitudinal study of a population consisting of 3563 subjects. In a long-term follow up 1947-2006 there were 66 suicide cases, including 19 undetermined deaths. Depression and alcoholism were as expected

NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum.

With few exceptions the endoplasmic reticulum (ER) is considered a continuous system of endomembranes within which proteins and ions can move. We have studied dynamic structural changes of the ER in hippocampal neurons in primary culture and organotypic slices. Fluorescence recovery after photobleaching (FRAP) was used to quantify and model ER structural dynamics. Ultrastructure was assessed by el

Emergency Management as Co-ordinated Cognitive Modelling on Different Time-scales

This report is a result of the work in projects for The Swedish Rescue Services Agency and for The National Board of Civil Emergency Preparedness. The problem is defined as difficulties in establishing rapid and effective management in major fire-fighting and rescue operations. The analyses result in a view that emergency management can be seen as cognitive modelling. The management work of major

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gesture, second language acquisition, reference tracking, French, Dutch, infomation structure, discourse

Den nya Uppsala-filosofin och brytningen med transcendentalismen

Artikeln rekonstruerar framväxten av den så kallade Uppsala-filosofin, framför allt representerad av Axel Hägerström, under 1900-talets första decennium. Bland annat lyfts betydelsen av Hägerströms föreläsning om Hegels logik under våren 1905 fram, liksom viktiga influenser från den så kallade neo-friesianska skolan kring Leonard Nelson.