Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

This edited collection proposes instituting as a potentially critical methodology in curating, art making and social organizing today, and seeks to discuss forms and structures that take place inside and outside institutions. Rethinking of collective artistic and social practices through and beyond the “waves of institutional critique” this books discusses instituting as a process in continuous cr

Indirect excitons are the focus of intense research due to the opportunity of studying degenerate quantum gases and liquids in an excitonic system. To realize such systems, it is highly advantageous to have as little scattering as possible. A polytype type-II interface is formed between wurtzite and zincblende InP due to the band alignment. Electrons gather on the zincblende and holes on the wurtz

Miniaturization of light-emitting diodes (LEDs) with sizes down to a few micrometers has become a hot topic in both academia and industry due to their attractive applications on self-emissive displays for high-definition televisions, augmented/mixed realities and head-up displays, and also on optogenetics, high-speed light communication, etc. The conventional top-down technology uses dry etching t

This chapter focuses on life science companies’ engagement with their university- based entrepreneurship ecosystem. It analyzes multiple case studies with life science companies based around Lund University in Sweden. Our results demonstrate that life science companies engage with their ecosystem through three interconnected engagement logics: network, relations, and governance. We propose a model

Children with cancer experience recurring hospitalizations and isolation during treatment, which affect their school attendance. This study explores experiences of children with cancer, their classmates, and teachers with using the telepresence robot as a learning mediator in the hybrid classroom during treatment periods. 31 children with cancer (aged 7–17 years), 30 teachers, and 118 classmates p

BackgroundA specific eHealth device, a surf tablet, was developed for bridging between advanced in-hospital care and children’s homes. Since little is known about determinators for parental eHealth usage, the study’s aim was to explore if parents’ usage of the device was associated with their eHealth literacy, or their satisfaction with their child’s healthcare or with the specific surf tablet.Met

By applying the theoretical concepts of wilderness, and uneven and combined development, I provide a partial environmental history of the French invasion of Egypt (1798-1801). This history addresses how Egypt’s ecological settings influenced the resistance to the French colonization attempt, and how the French occupation sought to change the ecological settings of Egypt and why. By reconstructing

RESUMEN EN ESPAÑOL: La lengua que utilizamos para comunicarnos está estrechamente relacionada con la manera en la que pensamos y cómo percibimos nuestro entorno. Aprender a pensar en una nueva lengua por lo tanto conlleva cambios cognitivos que van más allá del uso y dominio puramente lingüístico de la lengua. No sólo aprendemos nuevas formas de comunicación, sino que también adquirimos nuevas manLanguages are used to communicate and to perceive the environment. Therefore, they are related to the way in which human beings think and conceptualize the world. Consequently, learning a new language entails cognitive changes that go beyond the purely linguistic use and mastery of it. Thus, not only new forms are learned, but also new ways of describing and perceiving the world are acquired, sinc

Small-scale production has come to the forefront of debates on just and sustainable transformations of food systems because of their potential contributions to communities’ livelihoods and food security. Small-scale freshwater aquaculture holds the promise to positively contribute to income generation and food security [1]. Yet, the evidence of the relationship between them is scarce, particularly

Background:Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient’s skull. Extant research indicates that ABR is freq

To avoid catastrophic consequences of impending ecological crises our socio-economic systems need to be transformed in rapid and radical manners. Focusing on working life and Sweden as an example for countries of the Global North with a social-democratic welfare tradition, we ask how social protection systems may be reorganised according to the concept of ‘sustainable welfare’, the satisfaction of

The socioeconomic health gradient has widened in recent decades. We study how childhood socioeconomic neighborhood conditions influence gender- and cause-specific adult mortality. Using uniquely detailed geocoded longitudinal microdata for a Swedish town (1939–1967), with a follow-up in national registers (1968–2015), we apply Cox proportional hazards models and estimate individual neighborhoods a

Negotiations on a new international agreement to end plastic pollution are in progress, with the next committee meeting expected to focus on the list of control measures proposed in the initial “zero” draft. The document rightly urges nations to channel financial resources toward environmentally sustainable projects. However, this treaty draft disproportionately emphasizes waste management investm