Exogenous granulocyte-colony stimulating factor (G-CSF) has emerged as a drug candidate for improving the outcome after peripheral nerve injuries. We raised the question if exogenous G-CSF can improve nerve regeneration following a clinically relevant model - nerve transection and repair - in healthy and diabetic rats. In short-term experiments, distance of axonal regeneration and extent of injury

Fms-like tyrosine kinase (FLT3) is a frequently mutated oncogene in acute myeloid leukemia (AML). FLT3 inhibitors display promising results in a clinical setting, but patients relapse after short-term treatment due to the development of resistant disease. Therefore, a better understanding of FLT3 downstream signal transduction pathways will help to identify an alternative target for the treatment

Context. The prediction of the Planck-constrained primordial lithium abundance in the Universe is in discordance with the observed Li abundances in warm Population II dwarf and subgiant stars. Among the physically best motivated ideas, it has been suggested that this discrepancy can be alleviated if the stars observed today had undergone photospheric depletion of lithium. Aims. The cause of this d

An efficient numerical method for nearly simultaneous computation of all conditional moments needed for quasi maximum likelihood estimation of parameters in discretely observed stochastic differential equations is presented. The method is not restricted to any particular dynamics of the stochastic differential equation and is virtually insensitive to the sampling interval. The key contribution is

Braided convolutional codes (BCCs) are a type of parallel-concatenated convolutional code in which the parity outputs of one component encoder are fed back and used as inputs to the other component encoder at the succeeding time unit. In this paper, we review the published results on BCCs that have appeared in the literature over the past ten years and present a unified view of BCCs in the context

Generation of induced pluripotent stem cells (iPSCs) is a process whose mechanistic underpinnings are only beginning to emerge. Here, we applied in-depth quantitative proteomics to monitor proteome changes during the course of reprogramming of fibroblasts to iPSCs. We uncover a two-step resetting of the proteome during the first and last 3 days of reprogramming, with multiple functionally related

The most important goals for the field of immuno-oncology are to improve the response rate and increase the number of tumor indications that respond to immunotherapy, without increasing adverse side effects. One approach to achieve these goals is to use tumor-directed immunotherapy, i.e., to focus the immune activation to the most relevant part of the immune system. This may improve anti-tumor eff

Background: There is an urgent need to improve patient safety in the area of medication treatment among the elderly. The aim of this study was to explore which improvement needs and strengths, relating to medication safety, arise from a multi-professional intervention in primary care and further to describe and follow up on the agreements for change that were established within the intervention. M

A variety of factors have been identified as being risk factors for suicidal behaviour. One of them is the handling of stressful events. The aim of the present study was to investigate the coping-strategies used by suicide attempters and comparison groups. 37 pa- tients who had recently made a suicide attempt, 38 suicide attempters at follow up, 20 psychiatric follow up controls, and 19 healthy co

Skogar tillhandahåller en mångfald av produkter och tjänster som alla är kopplade till vattenresurser. Träd behöver vatten för att växa och samtidigt förändrar träd kvalitén och kvantiteten av avrinningen genom modifiering av vatten- och näringsämneskretsloppet. Förståelsen av samspelet mellan skog och vatten är grundläggande för att kunna utvärdera konsekvenserna av naturlig och antropogen påverkForests provide multiple products and services which are all are linked to water resources. Trees need water to grow and, at the same time, they change the quality and the quantity of runoff by modifying water and nutrient cycling. The understanding of the interactions between forest and water is fundamental to assess the consequences of natural and anthropogenic pressures, such as climate change

Heat exchanger network pinch sets the limitations of heat recovery for existing network topologies. Improving the heat recovery within a pinched-network is independent of the areas of individual exchangers present in the network, rather the topology of the network must be altered. Such a change in the topology can be very capital intensive and in many cases seems not easy to implement. This resear

This thesis analyzes some aspects of the appropriation of labor time and natural space in the Inka Empire (ca. AD 1400 – 1532) in order to illuminate the cultural organization of Inka imperial metabolism. Rather than understanding Inka imperialism simply as a political process with socioecological consequences, it is investigated as an ecological process organized through specific cultural categor

In order to cope with damage, plants have evolved a number of strategies. We incorporate two of those strategies, compensatory regrowth and escaping damage in time, into a mathematical model in an attempt to outline under what circumstances one or the other of these phenotypic traits will evolve. Escaping damage in time is accomplished by flowering and setting seeds at a point of time when the ris

Methods and apparatus in a mobile receiver for selecting among methods of estimating a received power of at least one signal. A method includes selecting a first method or a second method of measuring the received power based on a cell timing and a measurement interval. Information is received from a first base station about the measurement interval during which to perform the first method and theMethods and apparatus in a mobile receiver for selecting among methods of estimating a received power of at least one signal. A method includes selecting a first method or a second method of measuring the received power based on a cell timing and a measurement interval. Information is received from a first base station about the measurement interval during which to perform the first method and the