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Detector Development, Source Characterization and Novel Applications of Laser Ion Acceleration

The main focus of the work presented in this thesis is on experimental studies oflaser acceleration of protons and other positive ions from solid targets. The topic is explored from three different angles: firstly, the development of diagnostics adapted to the ion pulses, secondly, the characterization of the source of the energetic particles and, finally, the application of laser-accelerated prot

Visibility simulation of realistic grating interferometers including grating geometries and energy spectra

The performance of X-ray and neutron grating interferometers is characterised by their visibility, which is a measure for the maximum achievable contrast. In this study we show how the real grating geometry in a grating interferometer with three gratings impacts the interference and self projection that leads to visibility in the first place. We quantify the individual contributions of wavelength

Bellman Anakreon Hafiz : Gustaf Ljunggren och världslitteraturens skala

In his study of Carl Michael Bellman literary historian Gustaf Ljunggren (1823-1905) compared the Swedish poet not only to the traditional object of comnaprison, the ancient Greek poet Anacreon, but also to the Persian fourteenth-century poet Hafiz.This article revisits Ljunggren's work in light of recent discussions about world literature and the role of historical scale in literary studies. I in

Ion currents of cardiomyocytes in different regions of the Göttingen minipig heart

Introduction The Göttingen minipig is a promising model for pharmacological safety assessment and for translational research in cardiology. We have examined the main ion currents in cardiomyocytes of the minipig heart. Methods Cardiac cells were isolated from different cardiac regions (endo-, mid- and epicardial left ventricle and right ventricle) from Göttingen minipigs and examined using the who

ASLA 50 år : Ett samtal om tillämpad språkvetenskap - då, nu och i framtiden

Den svenska föreningen för tillämpad språkvetenskap (Association Suédoise de Linguistique Appliquée, ASLA) bildades formellt i april 1966 och firade således 50 år som förening under 2016. Jubileumet uppmärksammades på olika sätt under året. I samband med ASLA-symposiet i Uppsala den 21-22 april 2016 hölls ett panelsamtal på temat om tillämpad språkvetenskap då, nu och i framtiden. I den här texten

Estimation and Testing in Panel Data with Cross-Section Dependence

This thesis makes a contribution the econometrics of panel data with cross-section dependence (CSD). It consists of five self-contained papers. The most popular approach to account for CSD is to attribute the co-movements of observed variables across entities to unobserved common factors and to estimate these factors via simple cross-section averages of the data. The chapters in this thesis invest

Recombinant alpha-1-microglobulin : A potential treatment for preeclampsia

Preeclampsia is a serious pregnancy-specific condition, affecting 10 million women annually worldwide. No specific treatment is currently available. Recent studies have demonstrated abnormal production and accumulation of free fetal hemoglobin in the preeclamptic placenta, and identified subsequent leakage into the maternal circulation as an important factor in the development of preeclampsia. A r

A multi-criteria decision-model for prioritising stakeholder motives in city logistics

PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur

DCIP tomografi för kartläggning av jorddjup och strukturer i berg

Det finns planer på att bygga ett energilager i berget vid Önneslöv nära Dalby i Skåne. Berggrunden utgörs av en del av Romeleåsen och består huvudsakligen av gnejs med inslag av amfibolit och diabasgångar. Området ligger omedelbart söder om Sydstens stora bergtäkt, där det framgår att berget till stora delar är kraftigt uppsprucket med lervittrade zoner av olika storlek. I samband med byggande geThere are plans to build an energy storage in the rock at Önneslöv near Dalby in Skåne. The bedrock is of a part of Romeleåsen and mainly comprises gneiss, with elements of amphibolite and dolerite intrusions. The area is located immediately south of the Sydsten’s large rock quarry, which shows that the rock is mostly heavily fractured with clay weathered zones of different sizes. In connection wi

Modeling bumble bee population dynamics with delay differential equations

Bumble bees are ubiquitous creatures and crucial pollinators to a vast assortment of crops worldwide. Bumble bee populations have been decreasing in recent decades, with demise of flower resources and pesticide exposure being two of several suggested pressures causing declines. Many empirical investigations have been performed on bumble bees and their natural history is well documented, but the un

Fibre-reinforced composites with fibre-bending stiffness under azimuthal shear – Comparison of simulation results with analytical solutions

In Ref. [1], Spencer and Soldatos proposed an enhanced modelling approach for fibre-reinforced composites which accounts for the fibre-bending stiffness in addition to the directional dependency induced by the fibres. Although analytical solutions for simple geometries have been derived over the past years, often subject to specific assumptions such as small deformation kinematics, the application

A close-up of human dimensions of wildlife in Europe

In Europe an increasing number of scholars from different disciplines show growing interest in studying interactions between society and wildlife. Europe’s diversity with regard to cultures, languages and governance systems for wildlife is reflected in the wealth of research perspectives on human-wildlife interactions. Today a variety of approaches, disciplinary perspectives, theoretical framework

Large Eddy Simulation of a premixed bluff body stabilized flame using global and skeletal reaction mechanisms

The increasing computational capacity in recent years has spurred the growing use of combustion Large Eddy Simulation (LES) for engineering applications. The modeling of the subgrid stress and flux terms is well-established in LES, whereas the modeling of the filtered reaction rate terms is under intense development. The significance of the reaction mechanism is well documented, but only a few com

Active and separate secretion of fiber and penton base during the early phase of Ad2 or Ad5 infection

Fiber and penton base overproduced in adenovirus (Ad) infected cells can be secreted prior to progeny release and thereby regulate progeny spread. We aimed to investigate the mechanisms of fiber and penton base secretion in Ad2- or Ad5-infected A549 cells. Our flow cytometry analyses detected abundant surface fiber molecules, but little penton base molecules at 12 h post infection. Immunogold stai

Arsenic exposure from drinking water is associated with decreased gene expression and increased DNA methylation in peripheral blood

Background Exposure to inorganic arsenic increases the risk of cancer and non-malignant diseases. Inefficient arsenic metabolism is a marker for susceptibility to arsenic toxicity. Arsenic may alter gene expression, possibly by altering DNA methylation. Objectives To elucidate the associations between arsenic exposure, gene expression, and DNA methylation in peripheral blood, and the modifying eff

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels

Gastric bypass surgery results in remission of type 2 diabetes in the majority of patients. The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been implicated in the observed remission. Most knowledge so far has been generated in obese subjects. To isolate the surgical effects of gastric bypass on metabolism and hormone responses from