TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depletion

S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, coul

The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. In the fir

Secondary nucleation of monomers on the surface of an already existing aggregate that is formed from the same kind of monomers may lead to autocatalytic amplification of a self-assembly process. Such monomer-dependent secondary nucleation occurs during the crystallization of small molecules or proteins and self-assembled materials, as well as in protein self-assembly into fibrous structures. Indic

Common harmonic oscillator topologies, such as class-B and class-C, are typically unable to meet ultra stringent phase noise requirements, due to the exceedingly large capacitance (and, symmetrically, low inductance) that would be required in the parallel resonator. In this paper, we show that an oscillator making use of series resonators is ideally able to overcome this limitation, with the addit

Composite systems where quantum dots (QDs) are combined with other nanomaterials (e.g., gold nanorods) in aqueous solutions have attracted broad attention - both for their potential in applications and for studies of fundamental processes. However, high-quality QDs are typically prepared in organic solvents, and the transfer of QDs to an aqueous phase is needed to create the desired QD composites.

In this letter, the fading statistics of wireless channels in high-speed railway cutting scenarios are characterized based on measurements. A multiple scattering model called second-order scattering fading (SOSF) is used to model the small-scale fading considering the influence of cuttings and bridges. The SOSF model can offer the possibility of analytical estimation for different fading severitie

The paper describes a multidisciplinary conceptual design of an axial compressor, targeting a three stage, high speed, high efficiency booster with a design pressure ratio of 2.8. The paper is outlined in a step wise manner starting from basic aircraft and engine thrust requirements, establishing the definition of the high speed booster interface points and its location in the engine. Thereafter,

This work focuses on the geotechnical behaviour of three foundation solutions for windmills. The first design is a traditional flat raft, the second is a deep flat raft, and the third is a conical raft. A comparative study between the traditional and the new solutions is performed. A conical raft is used to improve the resistance of the soil-structure interface. It is shown that a conical raft giv

Low trap-state density, high carrier mobility, and efficient charge carrier collection are key parameters for photodetectors with high sensitivity and fast response time. This study demonstrates a simple solution growth method to prepare CsPbBr3 microcrystals (MCs) with low trap-state density. Time-dependent photoluminescence study with one-photon excitation (OPE) and two-photon excitation (TPE) i

Cloud computing technology provides the means to share physical resources among multiple users and data center ten- ants by exposing them as virtual resources. There is a strong industrial drive to use similar technology and concepts to provide timing sensitive services. One such is virtual net- working services, so called services chains, which consist of several interconnected virtual network fu

En domstolspedagogisk ansats Wittgensteins (1953) privatspråksargument utmanar förståelsen vad det innebär att korrekt följa regler. Paradoxen är att det inte verkar finnas någon möjlighet att logiskt hävda att en förklaring av en regel kan binda framtida tillämpningar. Argumentet utmanar regelförståelsen. Enligt Wittgenstein är regelföljande en praxis och inget som utgår från tolkningar. Kripke (

Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Agei

The ego depletion effect has been examined by over 300 independent studies during the past two decades. Despite its pervasive influence, recently this effect has been severely challenged and asserted to be a fake. Based on an up-to-date meta-analysis that examined the effectiveness of each frequently used depleting task, we preregistered the current experiment with the aim to examine whether there

Group A Streptococcus (GAS) is a common human pathogen and the etiologic agent of a large number of diseases ranging from mild, self-limiting infections to invasive life-threatening conditions. Two prominent virulence factors of this bacterium are the genetically and functionally linked pore-forming toxin streptolysin O (SLO) and its cotoxin NAD+-glycohydrolase (NADase). Overexpression of these to

Objectives: The symptoms of Posttraumatic Stress Disorder (PTSD) and chronic pain are thought to interact to increase the severity and impact of both conditions, but the mechanisms by which they interact remain unclear. This study examines the relationship between PTSD and chronic pain and whether indices of psychological flexibility mediate the relationship between these two conditions.Methods: S

Solvent effects on the decomposition of formic acid over a Co(111) surface were studied via density functional theory calculations combined with a continuum implicit solvation model. The solvents used here were water, methanol, and acetone. The adsorption energies of key intermediates, the activation barriers and the rate and equilibrium constants of various elementary reactions in vacuum and in t