Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6, inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppre

Due to their efficiency, revitalized traditional techniques for irrigation management of scarce water resources have been suggested as a way to at least partially cope with the present water crises in the Middle East. A better irrigation management includes re-using treated wastewater in agriculture. Treated wastewater should also be used in industrial processes, thus contributing to a more effici

In the scope of a Swedish research project on expert knowledge as a basis for legal decisions, this article focuses on serious criminal cases. Using a model that describes rhetorical situations as well as empirical material based in 150 court decisions, the aim is to analyze the conditions surrounding the use of expert evidence in criminal law processes, to what extent and by whom such evidence is

Ecosystem-based adaptation (i.e. the use of ecosystem services to adapt to climate change) and its mainstreaming into municipal planning to foster sustainable transformation is receiving increasing interest from both academic and governmental bodies. However, little is known about the pathways for its systematic implementation, or the extent to which it is already mainstreamed in municipal plannin

Miljontals människor världen över arbetar som gatuförsäljare, utom räckhåll för lagen. Eftersom verksamheten ses som illegal lever försäljarna under ett ständigt hot om att avhysas och att få sina varor konfiskerad. Olika strategier för formalisering, det vill säga stegvis legalisering, förespråkas och tillämpas, av såväl internationella utvecklingsorganisationer som regeringar, för att stärka gatMillions of people worldwide work outside the law as street vendors in order to earn a living. However, they often work in fear of police evictions and confiscations since their work is in many places considered illegal. In this context, formalization (steps towards legalization) is often portrayed as a model for empowerment that allows poor street vendors to improve their well-being. Formalizatio

Within the disciplines of social, economic, and evolutionary science, a proud ignorance can often be found of the other areas’ approaches. This text provides a novel intellectual basis for breaking this trend. Certainly, Human Sciences and Human Interests aspires to open a broad debate about what scholars in the different human sciences assume, imply or explicitly claim with regard to human intere

We investigate the conduction mechanisms of nitronyl-nitroxide (NIT) molecular radicals, as useful for the creation of nanoscopic molecular spintronic devices, finding that it does not correspond to standard Mott behavior, as previously postulated. We provide a complete investigation using transport measurements, low-energy, sub-THz spectroscopy and introducing differently substituted phenyl appen

This paper explores design students’ proposals for a redesign of the interior of a room of silence at the SUS hospital in Malmö. Reflection and existential meaning-making are discussed in relation to the material culture of design, and more specifically in relation to four different themes found among the students’ proposals: nature as common symbolic framework and salutary force; lighting creatin

In recent years, two Swedish companies have been a focus of substantial media attention: TeliaSonera and Lundin Petroleum. The defensive strategies employed by these two businesses to deal with allegations of crime will be analysed on the basis of Stanley Cohen’s theoretical work on processes of denial and neutralisation techniques. This paper will focus on a particular form of denial, namely the In recent years, two Swedish companies have been a focus of substantial media attention: TeliaSonera and Lundin Petroleum. The defensive strategies employed by these two businesses to deal with allegations of crime will be analysed on the basis of Stanley Cohen’s theoretical work on processes of denial and neutralisation techniques. This paper will focus on a particular form of denial, namely the

Drilling of a deep borehole does not normally allow for hydrologic testing during the drilling period. It is only done when drilling experiences a large loss (or high return) of drilling fluid due to penetration of a large-transmissivity zone. The paper proposes the possibility of conducting flowing fluid electrical conductivity (FFEC) logging during the drilling period, with negligible impact on

Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. The Ala222Val polymorphism of human MTHFR encodes a thermolabile protein associated with increased risk of neural tube defects and cardiovascular disease. Experimental studies have shown that the

Arrangements to cooperate on innovation facilitate access to external sources of knowledge. By using panel data derived from the five waves of Community Innovation Survey in the Czech Republic, we examine whether firms engage in these arrangements persistently or rather revert to other behaviour. Econometric estimates of dynamic random effects and multivariate probit models provide strong support

Much has been written about innovation cooperation, but little research has been done to explain the national differences thereof. Using macro and micro evidence from the fourth Community Innovation Survey, we econometrically investigate the extent to which national framework conditions account for the propensity of firms to cooperate on innovation at home and abroad. The results indicate strong d

The recent economic crisis caught many by surprise. Yet some firms were better prepared to weather the downturn than others. Using a unique micro dataset of shareholding companies from emerging countries in Eastern and Southern Europe derived from the World Bank's Enterprise Surveys, we econometrically test the hypothesis that pre-crisis innovation affected their survival odds and performance ther

Abstract: Administrative regions do not necessarily correspond to areas that are homogenous in terms of innovation intensity. Although this has been recognized in the literature, quantitative evidence that explicitly considers this problem is rare. Using spatial exploratory analysis on detailed regional data derived from a census of R&D performers in the Czech Republic, we identify local spati

Using panel micro data fro\m Community Innovation Survey in the Czech Republic, Norway and the UK, we estimate dynamic random effects models, in which the innovation output of firms is the function of their cooperative behaviour and other observed characteristics, while accounting for unobserved heterogeneity. The results indicate that the capacity of firms to build on external domestic linkages i

Much has been written on the distinction between vertical and horizontal foreign direct investment. However, most of the empirical literature relies on indirect and aggregated measures only. The aim of this paper is to help fill this gap by examining the differences between German affiliates in the Czech Republic and their mother companies in Germany on the basis of direct evidence on factor requi