Novel PARP14 inhibitors: their potency, their selectivity and their structures
Introduction: PARP14 is overexpressed and plays an essential role in the survival of many kinds of cancer cells and in inflammatory diseases, and its inhibition could prove to be a future medical treatment. Background: It is still unknown which structures contribute more to PARP14 binding, and because of how conserved the catalytic domain is in the PARP family, the inhibitors need to be selective
