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Introduction: Human epidermal growth factor receptor 2 (HER2)-amplified breast cancer represents a clinically well-defined subgroup due to availability of targeted treatment. However, HER2-amplified tumors have been shown to be heterogeneous at the genomic level by genome-wide microarray analyses, pointing towards a need of further investigations for identification of recurrent copy number alterat

Fuel economy and emissions are the two central parameters in heavy duty engines. High exhaust gas recirculation rates combined with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark ignition engines. With stoichiometric conditions, a three way catalyst can be used, which keeps the regulated emissions at very low levels. The Lambda

To fulfill increasing requirements in the manufacturing sector, companies are faced to several challenges. Three major challenges have been identified regarding time-to-market, vertical feedback loops and level of automation. Grafchart, a graphical language aimed for supervisory control applications, can be used from the process-planning phase, through the implementation phase and all the way to t

Severe lower extremity emboli with occlusion of all 3 lower limb arteries bilaterally occurred after an elective open abdominal aortic aneurysm (AAA) repair. Selective thrombolysis with alteplase and repeated percutaneous transluminal angioplasty (PTA) along the occlusions on both side anterior and posterior tibial arteries was performed without complications. Angiography the following day showed

The acquisition of nutrients is fundamental for the maintenance of bodily functions, growth, and reproduction in animals. As a result, fitness can be maximized only when animals are able to direct their attention to foods that reflect their current nutritional needs. Despite significant literature documenting the fitness consequences of nutrient composition and preference, less is known about the

Jet impingement is an effective heat transfer method while the favorable performance is usually degraded by the cross-flow. In this article, a novel control of the impinging jet in cross-flow has been proposed. A delta winglet vortex generator pair (VGP) is installed in the cross-flow channel upstream of the jet nozzle. The jet and the cross-flow Reynolds numbers are 15,000 and 40,000, respectivel

Objective Patients treated with antipsychotic drugs often receive concomitant psychotropic compounds. Few studies address this issue from a lifetime perspective. Here, an analysis is presented of the prescription pattern of such concomitant medication from the first contact with psychiatry until the last written note in the case history documents, in patients with a diagnosis of psychotic illness.

The main claim of this paper is that embedded V2 clauses in Mainland Scandinavian have the same syntactic structure as main clauses. This means that embedded V2 clauses contain a Force head, and as a consequence, embedded declarative V2 clauses will normally be asserted. Embedded V2 clauses are also similar to main clauses in that they contain linkers which encode the local speaker and addressee.

The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls

In several reports, the construction industry has been criticized for inefficiencies, errors and increasing costs. Although the industry's critics and researchers implicitly call for a change in human behaviour, this is seldom explicitly problematized by any of them. It is rather seen as a natural consequence of the suggested measures for improvements. Researchers have begun to question if the inf

Utilizing time series modeling entails estimating the model parameters and dispersion. Classical estimators for autocorrelated observations are sensitive to presence of different types of outliers and lead to bias estimation and misinterpretation. It is important to present robust methods for parameters estimation which are not influenced by contaminations. In this article, an estimation method en

Recent investigations have indicated that different solvation methods give qualitatively different results for the nonpolar solvation contribution to ligand-binding affinities. Therefore, we have calculated the nonpolar solvation contribution to the free energy of benzene binding to the T4 lysozyme Leu99Ala mutant using thermodynamic integration (TI) and three approximate methods. The total bindin

Objectives We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case control study from nine European countries. Methods After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27

A number of minimal problems of structure from motion for cameras with radial distortion have recently been studied and solved in some cases. These problems are known to be numerically very challenging and in several cases there were no practical algorithms yielding solutions in floating point arithmetic. We make some crucial observations concerning the floating point implementation of Gröbner bas

surgery (i.e. resection or liver transplantation), but only 10-20% of patients are candidates for this. In other patients, a variety of palliative treatments can be given, such as chemoembolization, radiofrequency ablation or recentlyPrimary liver cancers (i.e. hepatocellular carcinoma or cholangiocarcinoma) are worldwide some of the most frequent cancers, with rapidly fatal liver failure in a lar

The aim of the study was to identify whether a ventilated cooling shirt was effective in reducing heat strain in hot climate. 8 female volunteers (age: 26±5 years; height: 165±7 cm; body weight: 58±9 kg) were exposed in heat (38 °C, 45 % RH) for 2 hours with simulated office work. In the first hour they were in normal summer wears (total thermal insulation 0.7 clo); in the second hour a ventilated

The aim was to investigate job strain and stress of conscience among nurse assistants working in residential care and to explore associations with personal and work-related aspects and health complaints.

We revisit the question how inward FDI and multinational ownership affect relative labor demand. Motivated by the recent literature that distinguish between skills and tasks, we argue that the impact of multinational and foreign ownership on the demand for labor is better captured by focusing on job tasks rather than education. We use Swedish matched employer-employee data and find that changes of