Human monocytes are a heterogeneous cell population classified into three different subsets: Classical CD14++CD16-, intermediate CD14++CD16+, and non-classical CD14+CD16++ monocytes. These subsets are distinguished by their differential expression of CD14 and CD16, and unique gene expression profile. So far, the variation in inter-cellular gene expression within the monocyte subsets is largely unk

Reflective writing enhances personal and professional development. It is essential for the teachers to be familiar with the students' perceptions to improve the students' learning. Our aim was to deepen the understanding of the medical students' perceptions of the studies and the coming profession.

Since the early 1980s remarkable progress has been made in understanding the role of the HER2 locus in carcinogenesis, but many details of its regulatory network are still elusive. We recently reported the finding of 367 new human microRNA (miRNA) genes of which one, mir-4728, is encoded in an intron of the HER2 gene. Here, we confirm that the HER2 oncogene is a bi-functional locus encoding the me

ALICE is the LHC experiment dedicated to the study of heavy-ion collisions at extreme energy density where formation of the quark–gluon plasma is expected. Among the different observables, open heavy flavors and heavy quarkonia states are especially relevant. Indeed they will be copiously produced and they will provide sensitive information on the collision. In this paper, the ALICE muon spectrome

Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we demonstrated that adipocyte-related immediate early genes (IEGs) incl

The use of a transport system for out-oftreatment room set-up in external beam radiotherapy has been verified. We have looked into the vibrations which a patient is subject to during movement of the trolley as well as the accuracy achieved when using a reclining table for patient set-up and immobilization. The accuracy that can be achieved by the reclining approach is compared to conventional meth

Context. New instrumental capabilities and the wealth of astrophysical information extractable from the near-infrared wavelength region have led to a growing interest in the field of high resolution spectroscopy at 1-5 mu m. Aims. We aim to provide a library of observed high-resolution and high signal-to-noise-ratio near-infrared spectra of stars of various types throughout the Hertzsprung-Russell

Power and energy consumption, today essential in all types of systems, can be reduced by scaling the voltage/frequency at runtime and/or powering down idle components. Efficient management requires not only pertinent decisions, but also early access to workload information, as well as domain specific solutions. This paper focuses on runtime energy management for streaming applications running on m

Experiments performed with the high-contrast 0.7-J 35-fs Ti:sapphire laser at the Lund Laser Centre focused into a helium gas jet have produced quasi-monoenergetic electron beams with energies up to 150 MeV. The beam is produced as a result of controlled wavebreaking of a wakefield generated by the relativistically channeled laser beam. Under the best conditions of laser energy and plasma density,

Background: Array comparative genomic hybridization (aCGH) is commonly used to screen different types of genetic variation in humans and model species. Here, we performed aCGH using an oligonucleotide gene-expression array for a non-model species, the intertidal snail Littorina saxatilis. First, we tested what types of genetic variation can be detected by this method using direct re-sequencing and

Objectives To describe clinical history and ultrasound findings in patients with tubal carcinoma. Methods Patients with a histological diagnosis of tubal cancer who had undergone preoperative ultrasound examination were identified from the databases of 13 ultrasound centers. The tumors were described by the principal investigator at each contributing center on the basis of ultrasound images, ultra

Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancr

Background: In mental health care practice and research it is increasingly recognized that clients' subjective perceptions of everyday occupations, such as satisfaction, are important in recovery from mental illness. Instruments thus need to be developed to assess satisfaction with everyday occupations. The aim of the present study was to assess psychometric properties of the 13-item Satisfaction

Popular Abstract in Swedish Det enteriska nervsystemet (ENS) utgör mag-tarmkanalens eget nervsystem, ibland refererat till som “the second brain” då det uppvisar stora likheter med det centrala nervsystemet (CNS). Rubbningar i ENS ger bland annat störningar i tarmens motorik. Denna avhandling handlar om två sjukdomar i mag-tarmkanalen hos barn som bägge är uttryck för en rubbad motorik; HirschspruGastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. HD is a congenital disease characterized by an abscence of ganglion cells in myenteric and submucous ganglia, most commonly in the distal part of the large bowel. In Paper I, we have studied th

The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly exposed to microbes and their products, overt infection and damage is a rarity. An important componen

The role of G alpha i proteins coupled to chemokine receptors in directed migration of immune cells is well understood. In this study we show that the separate class of G alpha q/11 proteins is required for the underlying ability of T cells to migrate both randomly and in a directed chemokine-dependent manner. Interfering with G alpha q or G alpha 11 using dominant negative cDNA constructs or siRN