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Reliability of progressive and additive MRI scoring systems for evaluation of haemophilic arthropathy in children: Expert MRI Working Group of the International Prophylaxis Study Group

Effective treatment of haemophilic arthropathy requires a detailed evaluation of joint integrity. Methodological assessment of magnetic resonance imaging (MRI) scores are needed to assure reproducibility of measurements when comparing results of clinical trials conducted in different centres. We compared the reliability of two MRI scoring systems for assessment of haemophilic arthropathy: one prog

The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells

The recently cloned human chemoattractant receptor-like (CMKRL)1, which is expressed in vivo in CD4-positive immune cells, has structural homology with the two chemokine receptors C-C chemokine receptor (CCR)5 and C-X-C chemokine receptor (CXCR)4, which serve as the major coreceptors necessary for fusion of the HIV-1 envelope with target cells. In view of the structural similarity, CMKRL1 was test

Early nasogastric feeding in predicted severe acute pancreatitis: a clinical, randomized study.

Objective: To compare the efficacy and safety of early, nasogastric enteral nutrition (EN) with total parenteral nutrition (TPN) in patients with predicted severe acute pancreatitis (SAP). Summary Background Data: In SAP, the magnitude of the inflammatory response as well as increased intestinal permeability correlates with outcome. Enteral feeding has been suggested superior to parenteral feeding

Simultaneous saccharification and fermentation of steam-pretreated spruce to ethanol

Ethanol production was studied in simultaneous saccharification and fermentation (SSF) of steam-pretreated spruce at 42 degrees C, using a thermotolerant yeast. Three yeast strains of Kluyveromyces marxianus were compared in test fermentations. SSF experiments were performed with the best of these on 5% (w/w) of substrate, at a cellulase loading of 37 filter paper units/g of cellulose, and a beta-

Novel mechanisms of the regulation of Protein kinase B in adipocytes; implications for Protein kinase A, Epac, Phosphodiesterases 3 and 4.

Crosstalk between insulin and cAMP signalling pathways has a great impact on adipocyte metabolism. Whilst Protein kinase B (PKB) is a pivotal mediator of insulin action, in some cells regulation of PKB by cAMP has also been demonstrated. Here we provide evidence that, in a phosphatidyl inositol 3-kinase dependent manner, beta 3-adrenergic stimulation (using CL316243) in adipocytes induces PKB phos

Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD

Background: von Willebrand disease (VWD) type 1 is a congenital bleeding disorder caused by genetic defects in the von Willebrand factor (VWF) gene and characterized by a reduction of structurally normal VWF. The diagnosis of type 1 VWD is difficult because of clinical and laboratory variability. Furthermore, inconsistency of linkage between type 1 VWD and the VWF locus has been reported. Objectiv

Orbital entanglement in mesoscopic conductors

We present an investigation of orbital entanglement in mesoscopic conductors. Several schemes for generation of orbital entanglement are discussed, such as normal-superconducting, electron-hole and dynamic orbital entanglers. The generated, orbitally entangled state is investigated with the focus on the state emitted in an electronic analog of the optical Hanbury Brown Twiss experiment. The one an

The secret of the transmission of the unwritten Jesus tradition

Gospel research has drawn upon studies of folklore from time to time. An initial impetus from J. G. Herder was followed up by the work of the form critics. More recently, W. H. Kelber introduced to the debate a model based on modern folklore studies and linguistic theory known as 'oral culture' or 'orality'. He stressed the differences between oral ways of thinking, speaking, and transmitting trad

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index

Background. Several studies have investigated associations between the -174GC single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174GC was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI).

Extreme values and crossings for the chi^2-process and othe functions of multidimensional Gaussian processes, with reliability applications

Extreme values of non-linear functions of multivariate Gaussian processes are of considerable interest in engineering sciences dealing with the safety of structures. One then seeks the survival probability P{(X1(t),⋯ ,Xn(t))∈ S, all t∈ [0,T]}, where X(t)=(X1(t),⋯ ,Xn(t)) is a stationary, multivariate Gaussian load process, and S is a safe region. In general, the asymptotic survival probability for

Observations and simulations of some divergent-light halos

We deal with some halos generated by the divergent light from a nearby source. After discussing how the divergent light transforms some halo features, we give an outline of a method of handling the simulation of a divergent-light halo. The simulation method is then successfully tested on some well-documented halo observations. We also present a "simulation atlas" that shows halos produced by cryst

The geometric design of micromachined silicon sieve electrodes influences functional nerve regeneration

A neural interface could be used to control a limb prosthesis. Such an interface can be created by facilitating axonal regeneration through a sieve electrode and then register nerve signals intended to control the prosthesis. A key question is how to design the electrodes to ensure the best possible regeneration. Our previous studies have indicated that regeneration can be achieved using electrode

g-factor and exchange energy in a few-electron lateral InGaAs quantum dot

We report on the measurements of the g-factor and the exchange Interaction of electrons in a few-electron lateral quantum dot formed in an InGaAs/InP semiconductor heterostructure. The spin filling sequence of the electron states in the dot is determined by magnetotransport measurements and parallel spin filling configurations are Identified The measured g-factor (for a magnetic field applied para

rd1 Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans.

Background: The rd1 mouse retina displays fast degeneration of photoreceptors resulting in a depletion of almost all rod photoreceptors by postnatal day 21 (PN21). To evaluate the role of proteinases in the pathophysiology of this animal model of retinitis pigmentosa, C3H rd1 and congenic wild-type (wt) mice retinas were analyzed. Material and Methods: The cellular localization and levels of prote

Last interglacial atmospheric CO2 changes from stomatal index data and their relation to climate variations

A high-resolution atmospheric CO2 reconstruction based on stomatal index data obtained from Betula and Quercus leaf fragments extracted from the Danish Hollerup lake sediment section provides a unique insight into last interglacial CO2 dynamics. According to pollen stratigraphic correlations the CO2 record covers the first c. 7400 years of the Eemian, as palaeobotanically defined in northwestern E

Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running

We hypothesized that voluntary wheel running results in increased secretion of oxytocin, a peptide involved in the stress response. An additional hypothesis was that prolonged exercise affects oxytocin levels in the heart, which is in line with the potential role of oxytocin in cardiovascular functions. Voluntary wheel running lasted 3 weeks and daily running distances increased progressively reac

Chemiluminescence sensor for local equivalence ratio of reacting mixtures of fuel and air (FLAMESEEK)

This paper describes a Cassegrain optics-based chemiluminescence sensor (CS) for measurements in gas turbine combustors. The chemiluminescence sensor measures the equivalence ratio of reacting fuel and air mixtures, and can identify the flame location, in partially premixed flames. It has the potential for monitoring the degree of premixedness of reacting fuel and air in industrial gas turbine com