The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8αβ+ and CD4+CD8αα+ T cells; the latter requiring β8 integrin expression by migratory IRF8 depend

Denna avhandling består av fyra delstudier som undersöker hur internetreklam påverkar barns visuella uppmärksamhet. Syftet med studierna var att ta reda på om barn distraherades av internetreklam när de interagerade med webbsidor med hjälp av en vanlig webbläsare. Varje delstudie undersökte hur en specifik uppsättning variabler och faktorer gemensamt bidrog till att predicera hur barnen betraktadeThis dissertation consists of four eye-tracking studies that investigate how salient online advertising and children's level of executive function contributes to their advert distraction. In Study 1, children aged 9 were instructed to surf freely on the internet while all advert material appearing on-screen was registered. The analyses examined how perceptual prominence in each online advert was r

In recent years, there has been an upsurge of pan-European institutions, both from within the European Union and outside it, aiming to support European cinema. This article questions what it means to be a ‘European film institution’ in the contemporary film industry at a time when economic, political and cultural turmoil in the wake of the financial crisis affects this identity. The institution st

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically and phenotypically de

OBJECTIVE: The aim of this study was to analyze whether the associations between perceived environmental and individual characteristics and perceived walking limitations in older people differ between those with intact and those with poorer lower extremity performance.METHOD: Persons aged 75 to 90 (N= 834) participated in interviews and performance tests in their homes. Standard questionnaires wer

The increasing importance being placed on waste prevention in Swedish wastegovernance raises the question of how waste prevention is defined in practice.This paper presents a qualitative analysis of a sample of fifty-one key Swedishwaste prevention initiatives with the purpose of identifying which kind ofactions are imagined, promoted, and set into motion under the label of wasteprevention. The an

In this paper I study the public debt dynamics of three episodes (the crises of the 1950s, the 1980s and 2010-15) in Ireland’s modern economic history. By using traditional debt dynamic decomposition formulae, I measure the components which contributed most to public debt ratio reduction following previous high debt episodes. I also employ the case of Sweden for comparative purposes, in how it eme

BACKGROUND: There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI).OBJECTIVES: This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, inc

Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic AMP (cAMP) induction dramatically increases HSC-like cell frequencies. We show that hematopoietic cell generation requires cAMP signaling through th

Rapid decarbonization of whole countries requires additional research, development, and demonstration of low-carbon energy technologies. Governments support research, development, and demonstration in this area with various financing instruments. These instruments are frequently assessed by carrying out indicator-based evaluations. So far there is no standard set of indicators for this purpose. Th

Socio-economic differences in health and mortality are substantial and increasing today in many developed countries. The sources of these differences remain debated. There is an expanding literature showing that early-life conditions are linked to health in adulthood and old age. However, our knowledge about whether beneficial treatments in early life influence later health is still limited. Using