Hur man analyserar data från encells- och spatial transkriptomik – Och vad man kan upptäcka med dess hjälp Senaste tidens tekniska utveckling har gjort det möjligt att kartlägga enskilda cellers hela transkriptom – ett mått på vilka gener som uttrycks, dvs. är aktiva. Dessutom kan avancerad bildupptagning hjälpa till med att välja ut specifika områden i vävnadsprover, där man närmare undersöker gThere is a need to closer characterise the molecular changes associated with progression from low to high mortality stage cutaneous T cell lymphoma. This has been challenging since there is high inter-patient heterogeneity in the genetics and transcriptomics of the malignant T cell populations. Modern technology has enabled single-cell resolution as well as spatially guided cell selection for whol

Despite a large literature on the importance of childhood neighborhoods for life course transitions, there is a lack of fertility studies combining a life-course perspective with detailed neighborhood measures. Addressing this gap, we use longitudinal data in which the entire population of a Swedish town is geocoded at the address-level, 1939–1967, and linked to national registers from 1968 to 201

The aim of this study is to analyze how female reporters portray veganism in the Swedish weekly press between the years 2018-2023. Through a qualitative analysis and a critical discourse analysis the result shows that the portrayal of veganism emphasizes its beneficial impacts on health, the environment, and morality. The health and environmental discourses are positive towards veganism and you ca

This study examines the integration of climate change and biodiversity into business strategies and governance structures of listed firms on the Swedish stock exchange NasdaqOMX Large Cap. The results show clear disparities in the level of integration and the factors driving the integration process. All, but a few small firms, have integrated climate change into business strategies, and are ahead This study examines the integration of climate change and biodiversity into business strategies and governance structures of listed firms on the Swedish stock exchange NasdaqOMX Large Cap. The results show clear disparities in the level of integration and the factors driving the integration process. All, but a few small firms, have integrated climate change into business strategies, and are ahead

This review article describes microfabrication techniques to define chemical, mechanical and structural patterns in hydrogels and how these can be used to prepare in vivo like, i.e. biomimetic, cell culture scaffolds. Hydrogels are attractive materials for 3D cell cultures as they provide ideal culture conditions and they are becoming more prominently used. Single material gels without any modific

Every company on the verge of market entry faces a myriad of tough choices. Few are as fateful as which go-to-market strategy a company chooses to establish a foothold, entailing crossroads such as whether to prioritise growth or profitability and how to structure sales. This is the position that the white label insurtech Alpha Insurance find themselves in, with a go-to-market strategy in place bu

This report will discuss how principles from the advanced physics of cryogenics influenced my composition Der Rufer for percussion quartet. In this paper I explain how I translated information and concepts from superfluid helium (He II) to music composition. Achieved using different methods ranging from purely intuitive to quasi-quantitative, I transferred the following eight principles from ultra

Sirens (1998) is a tour-de-force of a new vocal style. A real crowd pleaser, this piece calls a pub from Joyce's Sirens the home for Ben Dollard, Stephen Dedaelus, Tom Kernan and Father (Bob) Cowley.

These two volumes of Kosmos (1998) are pedagogical models for the extended vocal techniques performer. Volume 1 has six pieces of various lengths for one to four parts featuring the composer's model of articulation. Volume 2 has fourteen pieces of various lengths for one to four parts dealing with reinforced harmonics. Both volumes can be performed by single players or by a choir.

Taffy Twisters (1998) features an extension of the composer's model of articulation.

The detection of oligonucleotides is a central step in many biomedical investigations. The most commonly used methods for detecting oligonucleotides often require concentration and amplification before detection. Therefore, developing detection methods with a direct read-out would be beneficial. Although commonly used for the detection of amplified oligonucleotides, fluorescent molecular beacons h

Context. The internal kinematics of the Large Magellanic Cloud (LMC) have been studied in unprecedented depth thanks to the excellent quality of the Gaia mission data, thus revealing the disc’s non-axisymmetric structure. Aims. We seek to constrain the LMC bar pattern speed using the astrometric and spectroscopic data from the Gaia mission. Methods. We applied three methods to evaluate the bar pat

Background: Tumor budding (Bd) is a suggested risk factor for recurrence and decreased survival in colorectal cancer. Histopathological detection of Bd indicates increased invasive and migratory potential of the tumor cells.Objectives: This study aimed to explore the impact of Bd on oncological outcomes.Design: Retrospective cohort study.Patient and Methods: Patients treated with abdominal curativ

Adolescence and emerging adulthood are key developmental stages with high risk for trauma exposure and the development of mental and substance use disorders (SUDs). The aim of this study was to compare the clinical profiles of adolescents (aged 12-17 years) and emerging adults (aged 18-25 years) presenting for treatment of posttraumatic stress disorder (PTSD) and SUD. Design/methodology/approach:

IMPORTANCE: Prostate-specific antigen (PSA) screening has potential to reduce prostate cancer mortality but frequently detects prostate cancer that is not clinically important.OBJECTIVE: To describe rates of low-grade (grade group 1) and high-grade (grade groups 2-5) prostate cancer identified among men invited to participate in a prostate cancer screening protocol consisting of a PSA test, a 4-ka