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Somatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutationa
Coastal erosion in Mozambique: Governing processes and remedial measures. Mozambique's 2800-km-long coastline comes with associated vulnerability to coastal erosion, their processes, and resulting evolution. In fact, coastal erosion has been identified as a dominant phenomenon in the Mozambican coastal system. It is driven by a combination of natural processes and anthropogenic actions. Despite th
Recent scholarly work has enhanced our understanding of how new path development activities are enabled or constrained by ‘regional environments’, made up of pre-existing industrial structures, knowledge organizations, support structures and institutional configurations. This paper moves beyond overly static views on regional environments. We develop a dynamic perspective by analysing conceptually
The progress in efficiency of organic photovoltaic devices is largely driven by the development of new donor–acceptor (D–A) copolymers. The number of possible D–A combinations escalates rapidly with the ever-increasing number of donor and acceptor units, and the design process often involves a trial-and-error approach. We here present a computationally efficient methodology for the prediction of o
The creatures that gaze back at us through the binocular microscope are so uniquely well-preserved and life-like that had we not known better we would have thought that they were modern. Instead they are half-a-billion-year-old arthropods extracted from Cambrian rocks of Sweden. The microscopic fossils, colloquially known as the 'Orsten' fossils, are now world-famous and basking in the light of th
We present a theory for the acoustic force density acting on inhomogeneous fluids in acoustic fields on time scales that are slow compared to the acoustic oscillation period. The acoustic force density depends on gradients in the density and compressibility of the fluid. For microfluidic systems, the theory predicts a relocation of the inhomogeneities into stable field-dependent configurations, wh
We describe an ERP effect termed the ‘pre-activation negativity’ (PrAN), which is proposed to index the degree of pre-activation of upcoming word-internal morphemes in speech processing. Using lexical competition measures based on word-initial speech fragments (WIFs), as well as statistical analyses of ERP data from three experiments, it is shown that the PrAN is sensitive to lexical competition a
We study the effect of birth weight on long-run outcomes using data on Swedish twins born between 1926 and 1958 linked to administrative records spanning entire life-time labor market histories. We find that birth weight positively affects permanent income and income across large parts of the lifecycle. The timing of the birth weight–income relationship is in line with the role of birth weight in
This chapter presents a narrative analysis of the life story of a Swedish Pentecostal who decided to join the Israeli Defense Forces out of his conviction that God wanted him to protect the chosen people. His story is treated as an example of lived Christian Zionism; as one of many manifestations that contemporary Christian affection for Israel can take. The analysis focuses on the central narrati
A general framework for analysing robust synchronization in large-scale heterogenous networks is proposed based on the theory of integral quadratic constraints (IQCs). Dynamic agents are represented as linear time-invariant single-input-single-output systems. The agents exchange information according to a sparse dynamical interconnection operator in order to achieve synchronization, where their ou
To keep the spatially averaged temperature and thermal stress of gas turbine blades and guide vanes within a permissible level, the present research concentrates on the optimization of the internal cooling passages in a guide vane. The main purpose is to search for the most optimal sizes, distributions, and shapes of internal cooling channels located in a guide vane. Cylindrical cooling passages a
Drawing from several years of field work and about 30 life story interviews,this chapter presents a case of contemporary evangelical mobility that cannotbe squarely placed within any of the related academic debates about ‘(religious)tourism’, ‘pilgrimage’, ‘short-term missions’, ‘international volunteering’ or ‘migration’ simply because it is intrinsically related to all these phenomena at the sam
ABSTRACT: Abnormal fatty acid metabolism and availability are landmarks of metabolic diseases, which in turn are associated with aberrant DNA methylation profiles. To understand the role of fatty acids in disease epigenetics, we sought DNA methylation profiles specifically induced by arachidonic (AA) or oleic acid (OA) in cultured cells and compared those with published profiles of normal and dise
The purpose of the present study is to try an alternative way of analyzing the ABR (Auditory Brainstem Response). The stimuli were complex sounds (c-ABR) as used in earlier studies. It was further aimed at corroborating earlier findings that this method can discriminate several neuropsychiatric states. Forty healthy control subjects, 26 subjects with the diagnosis schizophrenia (Sz) and 33 with AD
Relapse after successful initial correction of idiopathic clubfoot with the Ponseti method is often related to poor compliance with the foot abduction orthosis (FAO). The aim of this study was to evaluate treatment with custom-made dynamic orthoses. Twenty children with idiopathic clubfoot (30 feet) who had been treated with dynamic orthoses after the correction phase according to the Ponseti cast
Objective To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks’ gestation. Study design Prospectively enrolled women at 11 + 0 to 13 + 6 and 20 + 1 to 25 + 6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI)
This study reviews literature on the aspects of material selection within the field of industrial design education, specifically focusing on existing material selection tools and guidelines used in industrial design education. The growing number of materials available today has created a large variety of options for industrial designers, which they are ill-equipped to handle. A key reason behind t
