Helicobacter pylori-induced gastritis in guinea pigs: Model development, diagnostic methods and comparison with mouse protocols
Helicobacter pylori is a gram-negative spiral-shaped bacterium that colonizes the human stomach and causes gastric inflammation, gastric and duodenal peptic ulcers, gastric cancer and MALT-lymphoma. A novel guinea pig model of H. pylori infection was developed. Infection was induced by oral inoculation and was confirmed by cultivation from the stomach mucosa. The infection led to severe gastric in