Sökresultat

Filtyp

Din sökning på "*" gav 533932 sökträffar

Looking beyond the mountain: dispersal barriers in a changing world.

Dispersal barriers have demographic, evolutionary and ecosystem-wide consequences. With ongoing changes in the environment, it is likely that some dispersal barriers will disappear while others will appear, and it is crucial to understand these dynamics to forecast species distributions and adaptive potential. Here we review recent literature on the ecological and evolutionary aspects of dispersal

Search for leptonic charge asymmetry in tt¯ W production in final states with three leptons at √s = 13 TeV

A search for the leptonic charge asymmetry (Acℓ) of top-quark-antiquark pair production in association with a W boson (tt¯ W) is presented. The search is performed using final states with exactly three charged light leptons (electrons or muons) and is based on s = 13 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider at CERN during the years 2015–2018,

Experimental Investigation of Glycerol Derivatives as Low-Concentration Additives for Diesel Fuel

The worldwide adoption of renewable energy mandates, together with the widespread utilization of biofuels has created a sharp increase in the production of biodiesel (fatty acid alkyl esters). As a consequence, the production of glycerol, the main by-product of the transesterification of fatty acids, has increased accordingly, which has led to an oversupply of that compound on the markets. Therefo

Revisiting Rotation Averaging : Uncertainties and Robust Losses

In this paper, we revisit the rotation averaging problem applied in global Structure-from-Motion pipelines. We argue that the main problem of current methods is the minimized cost function that is only weakly connected with the input data via the estimated epipolar geometries. We propose to better model the underlying noise distributions by directly propagating the uncertainty from the point corre

The role of phosphorylation in calmodulin-mediated gating of human AQP0

Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation

Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate

In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible so

Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs.

Background: Although the clinical utility of categorically defined attention-deficit hyperactivity disorder (ADHD) is well established, there is also strong evidence supporting the notion of ADHD as an extreme of a continuous trait. Nevertheless, the question of whether the etiology is the same for different levels of DSM-IV ADHD symptoms remains to be investigated. The aim of this study was to as

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver.

During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) before settling in the adult bone marrow. We recently reported that proliferating adult HSCs are vulnerable to ER stress caused by accumulation of mis-folded proteins. Here, we find that FL-HSCs, despite an increased protein synthesis rate and a requirement for protein folding, do not upregulate E

Investigations of human EEG response to viewing fractal patterns.

Owing to the prevalence of fractal patterns in natural scenery and their growing impact on cultures around the world, fractals constitute a common feature of our daily visual experiences, raising an important question: what responses do fractals induce in the observer? We monitored subjects’ EEG while they were viewing fractals with different fractal dimensions, and the results show that significa

Induced variations in brassinosteroid genes define barley height and sturdiness, and expand the green revolution genetic toolkit

Reduced plant height and culm robustness are quantitative characteristics important for assuring cereal crop yield and quality under adverse weather conditions. A very limited number of short-culm mutant alleles were introduced into commercial crop cultivars during the Green Revolution. We identified phenotypic traits, including sturdy culm, specific for deficiencies in brassinosteroid biosynthesi

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

AIMS/HYPOTHESIS: Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1 alpha (protein PGC-1alpha; gene PPARGC1A) is a master regulator of mitochondrial genes and its expression is decreased and related to impaired oxidative phosphorylation in muscle from p