In a recent communication on carbon isotope chemostratigraphy of the uppermost Cambrian strata, it was claimed that the Top of Cambrian Excursion (TOCE) is (1) an undocumented negative δ13Ccarb excursion; (2) ambiguously defined; (3) deliberately fictitious or, in the authors’ words, a ‘nihilartikel’; and (4) not synonymous with the Hellnmaria–Red Tops Boundary (HERB) Event. As the authors who hav

The self-assembly of the protein tau into neurofibrillary tangles is one of the hallmarks of Alzheimer's disease and related tauopathies. Still, the molecular mechanism of tau aggregation is largely unknown. This problem may be addressed by systematically obtaining reproducible in vitro kinetics measurements under quiescent conditions in the absence of triggering substances. Here, we implement thi

Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling. Using this technique, previous studies have shown that γ-aminobutyric acid (GABA) expressing interneurons can be generated from different cell sources, such as glia cells or

In this study, large eddy simulations, coupled a two-equation soot model, are performed to investigate the effects of ambient carbon dioxide (CO2) and water (H2O) additions on the soot formation and oxidation processes in an n-dodecane spray flame. In the soot model, acetylene (C2H2) is soot precursor and surface growth species, while hydroxyl radical (OH) and oxygen (O2) are soot oxidizers. The e

Calls for transformative change and participatory modes of knowledge production demand researchers to assume new roles. This paper synthesizes the literature on knowledge co-production and researcher roles to explore challenges for researchers involved in transdisciplinary environmental management projects. Our research methods combine a scoping review and reflections on personal experiences with

We tested concentration-dependence of selected gene transcripts (cat, gst, hsp70, hsp90, mt and sod) for evaluation as biomarkers of chemical stress. Contrary to the common approach of factorial designs and few exposure concentrations, we used regression across a high-resolution concentration series. Specifically, freshwater mussels (Anodonta anatina) were acutely (96 h) exposed to Cu (13 nominal

The study of diffusion anisotropy via diffusion NMR was pioneered 40 years ago in systems pertaining to the field of porous media. Since then, its combination with MRI has attracted overwhelming interest within the neuroscience community as a way to perform non-invasive in vivo assessment of tissue microstructure. However, most conventional diffusion MRI techniques measured diffusion anisotropy me

The X-ray absorption spectrum of N2+ in the K-edge region has been measured by irradiation of ions stored in a cryogenic radio frequency ion trap with synchrotron radiation. We interpret the experimental results with the help of restricted active space multiconfiguration theory. Spectroscopic constants of the 1σu-1 ς2u+ state, and the two 1σu-13σg-11πg Π2u states are determined from the measuremen

This article proceeds from a critical analysis of gendered narratives of nationhood as manifested in far-right populist politics and discourses in response to major security challenges. We focus on how such narratives exemplify gendered nationalism and inform the discourses of populist political leaders and their followers, with a particular focus on the USA and the UK. We proceed from an engageme

Powertrain efficiency is a critical factor in lowering fuel consumption and reducing the emission of greenhouse gases for an internal combustion engine. One method to increase the powertrain efficiency is to recover some of the wasted heat from the engine using a waste heat recovery system e.g. an organic Rankine cycle. Most waste heat recovery systems in use today for combustion engines use the w

Solar energy simulations are used to quantify the potential of the passive use (daylight, solar gains) and the active use (photovoltaics and solar thermal) of solar energy. The simulations can be performed at different scales e.g. buildings, neighbourhoods and cities, with different requirements on the data. For example, for the neighbourhood simulations we need simplified building geometries that

Purpose: Breast cancer is one of the most common cancer forms in women and it is often detected by screening. However, women with drug use disorders (DUD) are less likely to be reached by screening programs. In this study, we aimed to investigate breast cancer incidence, mortality and stage at time of diagnosis among women with DUD compared to the general female population in Sweden. Methods: We p

The existing information supports the use of this material as described in this safety assessment. 2-Decanone was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-heptanone (CAS # 110-43-0) show that 2-decanone is not expected to be ge

The nitrogen cycle and its effect on carbon uptake in the terrestrial biosphere is a recent progression in earth system models. As with any new component of a model, it is important to understand the behaviour, strengths, and limitations of the various process representations. Here we assess and compare five land surface models with nitrogen cycles that are used as the terrestrial components of so

BACKGROUND: Tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) have unique, individual patterns that pose significant challenges for diagnosis, psycho-education, and intervention planning. A recent study suggested that it may be feasible to use TAND Checklist data and data-driven methods to generate natural TAND clusters. However, the study had a small sample size and da

With conventional antibiotic therapies being increasingly ineffective, bacterial infections with subsequent biofilm formation represent a global threat to human health. Here, an active and a passive strategy based on polymeric micelles were combined to fight bacterial growth. The passive strategy involved covalent immobilization of polymeric micelles through Michael addition between exposed maleim