Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate.
Objectives To identify effect modification produced by genetic traits found in metabolic enzymes, to investigate how these affect the levels of different biomarkers of sprayed and thermo-degraded polyurethane (PUR) based on 4,4′-diphenylmethane diisocyanate (MDI) and to determine how associated respiratory disorders are affected. Methods Two partly overlapping groups of 141 and 158 factory employe